Emulsified Vit A (as By Harold Manner) By Itself Cures 33% Of Acute Promyelocytic Leukemia Patients

burtlancast

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Back in the 80's, Harold Manner published evidence of high dose emulsified Vit A, bypassing the liver, able to greatly help cancer patients, when added to laetrile, DMSO and enzymes.

In 2006, researchers at the Texas M.D. Anderson Cancer Center reported this same emulsified Vit A, given only by itself, could cure 33% of acute promyelocytic leukemia patients by inducing normal differentiation of the leukemic cells.

"Ten of the 26 responders to Lipo-ATRA remain in first complete remision at a median of 6.4 years, despite never receiving idarubicin; all 10 had initial WBC counts <10 x 10(9)/L. The 5-year survival rate was 76% for patients treated with Lipo-ATRA."


"Acute promyelocytic leukemia (APL) is characterized by the arrest of cell maturation at the promyelocytic stage, caused by chromosomal translocations involving the retinoic acid receptor alpha (RARa) locus on chromosome 17 and one of five partner genes, most often the promyelocytic leukemia (PML) gene on chromosome 15 [1]."

Press release: http://undergroundhealthreporter.com/vitamin-a-benefits-chemotherapy/
Original scientific study: Single-agent liposomal all-trans retinoic acid can cure some patients with untreated acute promyelocytic leukemia: an update of The University of T... - PubMed - NCBI
 
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Braveheart

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Back in the 80's, Harold Manner published evidence of high dose emulsified Vit A, bypassing the liver, able to greatly help cancer patients, when added to laetrile, DMSO and enzymes.

In 2006, researchers at the Texas M.D. Anderson Cancer Center reported this same emulsified Vit A, given only by itself, could cure 33% of acute promyelocytic leukemia patients by inducing normal differentiation of the leukemic cells.

"Ten of the 26 responders to Lipo-ATRA remain in first complete remision at a median of 6.4 years, despite never receiving idarubicin; all 10 had initial WBC counts <10 x 10(9)/L. The 5-year survival rate was 76% for patients treated with Lipo-ATRA."


"Acute promyelocytic leukemia (APL) is characterized by the arrest of cell maturation at the promyelocytic stage, caused by chromosomal translocations involving the retinoic acid receptor alpha (RARa) locus on chromosome 17 and one of five partner genes, most often the promyelocytic leukemia (PML) gene on chromosome 15 [1]."

Press release: http://undergroundhealthreporter.com/vitamin-a-benefits-chemotherapy/
Original scientific study: Single-agent liposomal all-trans retinoic acid can cure some patients with untreated acute promyelocytic leukemia: an update of The University of T... - PubMed - NCBI
Nice...thank you!
 

haidut

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Back in the 80's, Harold Manner published evidence of high dose emulsified Vit A, bypassing the liver, able to greatly help cancer patients, when added to laetrile, DMSO and enzymes.

In 2006, researchers at the Texas M.D. Anderson Cancer Center reported this same emulsified Vit A, given only by itself, could cure 33% of acute promyelocytic leukemia patients by inducing normal differentiation of the leukemic cells.

"Ten of the 26 responders to Lipo-ATRA remain in first complete remision at a median of 6.4 years, despite never receiving idarubicin; all 10 had initial WBC counts <10 x 10(9)/L. The 5-year survival rate was 76% for patients treated with Lipo-ATRA."


"Acute promyelocytic leukemia (APL) is characterized by the arrest of cell maturation at the promyelocytic stage, caused by chromosomal translocations involving the retinoic acid receptor alpha (RARa) locus on chromosome 17 and one of five partner genes, most often the promyelocytic leukemia (PML) gene on chromosome 15 [1]."

Press release: http://undergroundhealthreporter.com/vitamin-a-benefits-chemotherapy/
Original scientific study: Single-agent liposomal all-trans retinoic acid can cure some patients with untreated acute promyelocytic leukemia: an update of The University of T... - PubMed - NCBI

I bet vitamin A dissolved in vitamin E is even more effective as it can bypass the liver a lot more effectiveness than simple fat emulsions.
 

Amazoniac

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burtlan, I was confused with your post on the vitamin A toxicity thread because it is supposed to be carried through the lympathic of the systems by lipoproteins either way:

Mechanisms involved in the intestinal absorption of dietary vitamin A and provitamin A carotenoids
"The in vivo intestinal absorption of carotenoids involves several crucial steps: 1) release of carotenoids from the food matrix, 2) solubilization of carotenoids into mixed lipid micelles in the lumen, 3) cellular uptake of carotenoids by intestinal mucosal cells, 4) incorporation of carotenoids into chylomicrons (CM) and 5) secretion of carotenoids and their metabolites associated with CM into the lymph."​

Therefore during absorption they already assume that configuration. However! (Travis, 2017-18) Now that you posted this, seems that the success comes from giving retinoic of the acids, which is the active form and so you don't rely on its activation anymore (gbolduev, 2017).

Most of its functions depend on retinoic acid:

The Roles of Vitamin A in the Regulation of Carbohydrate, Lipid, and Protein Metabolism
upload_2018-7-17_11-54-1.png

(already shared elsewhere)​

Proper vitamin A metabolism depends on many nutrients, so it isn't difficult to think that it's very prone to become impaired in sickness.

There are many reviews on retinoids use in cancer. Isotretinoin was initially used as a chemotherapeutic drug (S. Saturation, 2015). The challenging aspect seems to be making it work in the body again.

Giving preformed vitamin A already skips some steps, which can be useful:

Will in 'The Survival Factor' said:
Highly polar double bonds can add free radicals of the high efficiency oxidation process, especially those developed during the Survival oxidations, and block the recovery process before it even gets a good start. Illuminating gas, exhaust gases from combustion engines, chimney smoke from oil burners, paint solvents, and floor wax solvents, many terpenoid substances, as those in the skins of citrus fruits, and even too much carotene in the food are to be avoided. The cancer patient, for example, is somewhat night-blind, simply because he cannot oxidize carotene to vitamin A, as efficiently as he should. He should receive his vitamin A, in the form of fish liver oil, and not as the previtamin sold as vitamin A.

But I'm not confident that it works on its own on weak people. At least not when given in the storage forms.

(I find this kind of appropriation ridiculous). I lIkE. But is it really that difficult to give the credit by writing instead:
In 2015, S. Saturation wrote that isotretinoin..?
 
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burtlancast

burtlancast

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burtlan, I was confused with your post on the vitamin A toxicity thread because it is supposed to be carried through the lympathic of the systems by lipoproteins either way:

During absorption, part of the Vit A is going through the portal vein straight to the liver.


"Recent research has shown that not all vitamin A in the oil
form (means not emulsified) is going to the liver via the portal route in
"significant amounts." For instance, all of the vitamin
A in the form of retinoic acid absorbed in the small
intestine is going through the portal route to the liver
while the other forms absorbed are going to the liver
in varying amounts according to one researcher. The
oil form that enters the lymph system travels through
the system and blood system in chylomicrons until it
reaches the liver. The liver is the storage organ for
vitamin A, and in fact, about 90% of vitamin A is
stored there. Since much of the vitamin A travels
directly to the liver, upon absorption one can see a
fast and high concentration of vitamin A in the liver
causing toxicity if the vitamin A is ingested in large
amounts. This is what happens when the oil form of
vitamin A is used."


"When the oil
form of vitamin A is absorbed and enters the lymphatic
route, it travels bound in a chylomicron complex
that does not allow the vitamin A to enter all tissues.
It will be bound in this form either until it enters the
liver or until the chylomicron splits apart, which
usually takes about ten minutes.
By this time most of
the oil form will have entered the liver where it will
later be dispensed as required by the body. The
emulsified form enters through the lymphatic system,

but since it is water soluble and not bound in a
chylomicron, it is able to enter all the tissues. Thus,
one can observe the loading up of the liver with the oil
vitamin A when used in high amounts, but not to the
same degree when taken in the emulsified form."
 
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Amazoniac

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During absorption, part of the Vit A is going through the portal vein straight to the liver.
So from what I made the readings, it only goes through that route as oxidized retinoic acid, therefore if the liver can't do anything useful it's going to be excreted. The major route is circulating through lymphs carried by chylomicrons. I guess this forces each tissue to convert the esters to retinoic acid, but this might be impaired in disease. Perhaps then the main benefit is packing retinoic acid to be able to circulate and be delivered to tissues without requiring activation.
 
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burtlancast

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burtlancast

burtlancast

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I bet vitamin A dissolved in vitamin E is even more effective as it can bypass the liver a lot more effectiveness than simple fat emulsions.

Here's what Manner writes:


"Vitamin A putrifies upon oxidation. This can
happen when taken orally any place along the alimentary
tract. It can happen when exposed to air for
a period of time. To prevent this from occurring,
especially when taken in high amounts of the emulsified
form, small amounts of vitamin E are either
added to the emulsion or taken with the vitamin A.
Vitamin E is an antioxidant, and it has been reported
that a small addition of vitamin E markedly enhances
vitamin A utilization by the body
. Vitamin E also
improves the vitamin A intestinal absorption. Vitamin
E, then, is essential in normal vitamin A utilization."
 

tallglass13

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I think there are warnings against Vitamin A toxicity, according to Ray Peat. Plus , Accutane has injured so many people , along with other Vitamin A .
 

Amazoniac

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Inside the same press-release, there's the account from another study from 1990 by Indian researchers where beta carotene inhibits at 100% aflatoxin-induced liver cancer.

Good luck finding the whole study, lol.

Association of reduction of AFB1-induced liver tumours by antioxidants with increased activity of microsomal enzymes. - PubMed - NCBI
Indeed vitamin A protects against toxins but only as long as you can protect it. The problem is that people's diet already provide carotenes, many also supplement multivitamins, and most cancers don't start because a toxin was too great, but because the body was too weak from chronic degeneration. It's different than various lab experiments of acute induction. I don't think carotenes alone can do the job, the retinyl esters might not either. I can be wrong.
With the vitamins we have a similar situation as we saw with the hormones. I damaged patients with vitamin A, vitamin E, vitamin B and B6. Patients get really damaged. Vitamin A and D are picked up by the cancer cells immediately. Niacin we can use, that is B3.
 

Amazoniac

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Retinoids and their biological effects against cancer

"Recent reports have shown a correlation between the ability of tumor promoters to induce the activities of polyamine-biosynthetic enzymes (more than 200-fold) and their tumor promoting potency [48,49]. Topical application of retinol acid to mouse skin led to a dramatic inhibition of phorbol ester-induced epidermal ornithine decarboxylase (ODC) activity, an event proposed to be essential for tumor promotion. The degree of inhibition was dependent on the dose and time of application of retinoic acid [48,49]. A number of natural vitamin A analogs (retinoids) were tested for their ability to inhibit epidermal ODC activity and were found to be potent as following:

Retinoic acid > Retinal > Retinol > Retinyl acetate > Retinyl palmitate.​

In addition, β-retinoic acid, haventpostedhereyet-retinoic acid, 13-cis-retinoic acid, 13- cis-retinal and 5, 6-dihydroretinoic acid, as well as the dimethylmethoxyethylcyclopentenyl and dimethylacetylcyclopentenyl analogs of retinol acid, were among the potent inhibitors of skin tumor promotion. Indeed, less than 1 nmol was required to give 50% inhibition [48,49]. Treatment with acyclic retinoid produces a dual activation of caspase 3-induced apoptosis of hepatocellular carcinoma cells resulting in reduced expression of epidermal growth factor receptor (EGFR) [47].

Retinoids exert their effects through a variety of binding proteins including cellular retinol binding protein (CRBP), retinol-binding proteins (RBP), cellular retinoic acid-binding protein (CRABP) and nuclear receptors i.e. retinoic acid receptor (RAR) and retinoid X receptor (RXR). Retinoid-binding proteins solubilize and stabilize retinoids in aqueous spaces [13]."
 

franko

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Back in the 80's, Harold Manner published evidence of high dose emulsified Vit A, bypassing the liver, able to greatly help cancer patients, when added to laetrile, DMSO and enzymes.

In 2006, researchers at the Texas M.D. Anderson Cancer Center reported this same emulsified Vit A, given only by itself, could cure 33% of acute promyelocytic leukemia patients by inducing normal differentiation of the leukemic cells.

"Ten of the 26 responders to Lipo-ATRA remain in first complete remision at a median of 6.4 years, despite never receiving idarubicin; all 10 had initial WBC counts <10 x 10(9)/L. The 5-year survival rate was 76% for patients treated with Lipo-ATRA."


"Acute promyelocytic leukemia (APL) is characterized by the arrest of cell maturation at the promyelocytic stage, caused by chromosomal translocations involving the retinoic acid receptor alpha (RARa) locus on chromosome 17 and one of five partner genes, most often the promyelocytic leukemia (PML) gene on chromosome 15 [1]."

Press release: http://undergroundhealthreporter.com/vitamin-a-benefits-chemotherapy/
Original scientific study: Single-agent liposomal all-trans retinoic acid can cure some patients with untreated acute promyelocytic leukemia: an update of The University of T... - PubMed - NCBI


Nope. That's not a cure at all.

At best you could call it a "treatment" — but that's way too generous a word for a chemotherapy — a moderately generous phrase would be "targeted poisoning" — but more accurate would be: "a general poisoning".

The only way to truly cure cancer is to prevent the cause of cancer.

Are you suggesting the cause of cancer is a lack of retinoids in the bloodstream?

The only study you linked to uses "all-trans retinoic acid" aka "tretinoin".

In essence, these are functionally equivalent in the body:

Retinoic AcidTretinoin (Retin-a) ≈ Isotretinoin (Accutane)

Why bother with emulsified vitamin A when you can just use retinoic acid to accomplish the same thing — like Big Pharma already does? And in fact, the VA probably works just because it converts into RA in the body.

And, retinoic acid may kill cancerous cells — but it kills lots of healthy cells too:

Isotretinoin's exact mechanism of action is unknown, but several studies have shown that isotretinoin induces apoptosis (programmatic cell death) in various cells in the body. Cell death may be instigated in the meibomian glands,[27][52] hypothalamic cells,[53] hippocampus cells[54][55] and—important for treatment of acne—in sebaceous gland cells.

Isotretinoin - Wikipedia

That's how you know it's not a "cure" — it's just a cell-killer (aka a poison).

I thought it was well-understood in alternative health circles, that chemotherapy takes this approach: Just poison the patient and hope that the cancer cells die before the patient does, then cease the poisoning.

So it may kill your cancer but meanwhile, this is what tretinoin does to the rest of your body:

"Skin use
Topical tretinoin is only for use on skin and it should not be applied to eyes or mucosal tissues. Common side effects include skin irritation, redness, swelling, and blistering.[7]

Leukemia use
The oral form of the drug has boxed warnings concerning the risks of retinoic acid syndrome and leukocytosis.[9]

Other significant side effects include a risk of thrombosis, benign intracranial hypertension in children, high lipids (hypercholesterolemia and/or hypertriglyceridemia), and liver damage.[9]

There are many significant side effects from this drug that include malaise (66%), shivering (63%), hemorrhage (60%), infections (58%), peripheral edema (52%), pain (37%), chest discomfort (32%), edema (29%), disseminated intravascular coagulation (26%), weight increase (23%), injection site reactions (17%), anorexia (17%), weight decrease (17%), and myalgia (14%).[9]

Respiratory side effects usually signify retinoic acid syndrome, and include upper respiratory tract disorders (63%), dyspnea (60%), respiratory insufficiency (26%), pleural effusion (20%), pneumonia (14%), rales (14%), and expiratory wheezing (14%), and many others at less than 10%.[9]

Around 23% of people taking the drug have reported eararche or a feeling of fullness in their ears.[9]

Gastrointestinal disorders include bleeding (34%), abdominal pain (31%), diarrhea (23%), constipation (17%), dyspepsia (14%), and swollen belly (11%) and many others at less than 10%.[9]

In the cardiovascular system, side effects include arrhythmias (23%), flushing (23%), hypotension (14%), hypertension (11%), phlebitis (11%), and cardiac failure (6%) and for 3% of patients: cardiac arrest, myocardial infarction, enlarged heart, heart murmur, ischemia, stroke, myocarditis, pericarditis, pulmonary hypertension, secondary cardiomyopathy.[9]

In the nervous system, side effects include dizziness (20%), paresthesias (17%), anxiety (17%), insomnia (14%), depression (14%), confusion (11%), and many others at less than 10% frequency.[9]

In the urinary system, side effects include renal insufficiency (11%) and several others at less than 10% frequency.[9]"

Tretinoin - Wikipedia
Does that sound like a cure to you?

Sounds to me like an generally destructive poison. Just like other chemotherapy treatments (including arsenic and compounds derived from mustard gas research).

And that's not even the full list of side effects of tretinoin.
Read the full list of side effects for yourself here: Wayback Machine
I've attached that as a PDF.

And yes, I learned all this from the basis of Genereux's research.
 

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burtlancast

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Sounds to me like an generally destructive poison. Just like other chemotherapy treatments (including arsenic and compounds derived from mustard gas research).

Do you know of any internal DNA receptor for arsenic or mustard gas, lol ?

How does the body create a DNA receptor for something he never needed in the first place ?
 
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burtlancast

burtlancast

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I don't think carotenes alone can do the job, the retinyl esters might not either. I can be wrong.

Gerson said:
With the vitamins we have a similar situation as we saw with the hormones. I damaged patients with vitamin A, vitamin E, vitamin B and B6. Patients get really damaged. Vitamin A and D are picked up by the cancer cells immediately. Niacin we can use, that is B3.

Well, this is the beauty of advancing medical research: Gerson damages patients with usual Vit A, Harold Manner and German oncologists (Manner learned everything from them) use emulsified Vit A in gigantic doses to cure some cancers and put in remission others.

You cannot argue with the facts.
 

nwo2012

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Nope. That's not a cure at all.

At best you could call it a "treatment" — but that's way too generous a word for a chemotherapy — a moderately generous phrase would be "targeted poisoning" — but more accurate would be: "a general poisoning".

The only way to truly cure cancer is to prevent the cause of cancer.

Are you suggesting the cause of cancer is a lack of retinoids in the bloodstream?

The only study you linked to uses "all-trans retinoic acid" aka "tretinoin".

In essence, these are functionally equivalent in the body:

Retinoic AcidTretinoin (Retin-a) ≈ Isotretinoin (Accutane)

Why bother with emulsified vitamin A when you can just use retinoic acid to accomplish the same thing — like Big Pharma already does? And in fact, the VA probably works just because it converts into RA in the body.

And, retinoic acid may kill cancerous cells — but it kills lots of healthy cells too:

Isotretinoin's exact mechanism of action is unknown, but several studies have shown that isotretinoin induces apoptosis (programmatic cell death) in various cells in the body. Cell death may be instigated in the meibomian glands,[27][52] hypothalamic cells,[53] hippocampus cells[54][55] and—important for treatment of acne—in sebaceous gland cells.

Isotretinoin - Wikipedia

That's how you know it's not a "cure" — it's just a cell-killer (aka a poison).

I thought it was well-understood in alternative health circles, that chemotherapy takes this approach: Just poison the patient and hope that the cancer cells die before the patient does, then cease the poisoning.

So it may kill your cancer but meanwhile, this is what tretinoin does to the rest of your body:

"Skin use
Topical tretinoin is only for use on skin and it should not be applied to eyes or mucosal tissues. Common side effects include skin irritation, redness, swelling, and blistering.[7]

Leukemia use
The oral form of the drug has boxed warnings concerning the risks of retinoic acid syndrome and leukocytosis.[9]

Other significant side effects include a risk of thrombosis, benign intracranial hypertension in children, high lipids (hypercholesterolemia and/or hypertriglyceridemia), and liver damage.[9]

There are many significant side effects from this drug that include malaise (66%), shivering (63%), hemorrhage (60%), infections (58%), peripheral edema (52%), pain (37%), chest discomfort (32%), edema (29%), disseminated intravascular coagulation (26%), weight increase (23%), injection site reactions (17%), anorexia (17%), weight decrease (17%), and myalgia (14%).[9]

Respiratory side effects usually signify retinoic acid syndrome, and include upper respiratory tract disorders (63%), dyspnea (60%), respiratory insufficiency (26%), pleural effusion (20%), pneumonia (14%), rales (14%), and expiratory wheezing (14%), and many others at less than 10%.[9]

Around 23% of people taking the drug have reported eararche or a feeling of fullness in their ears.[9]

Gastrointestinal disorders include bleeding (34%), abdominal pain (31%), diarrhea (23%), constipation (17%), dyspepsia (14%), and swollen belly (11%) and many others at less than 10%.[9]

In the cardiovascular system, side effects include arrhythmias (23%), flushing (23%), hypotension (14%), hypertension (11%), phlebitis (11%), and cardiac failure (6%) and for 3% of patients: cardiac arrest, myocardial infarction, enlarged heart, heart murmur, ischemia, stroke, myocarditis, pericarditis, pulmonary hypertension, secondary cardiomyopathy.[9]

In the nervous system, side effects include dizziness (20%), paresthesias (17%), anxiety (17%), insomnia (14%), depression (14%), confusion (11%), and many others at less than 10% frequency.[9]

In the urinary system, side effects include renal insufficiency (11%) and several others at less than 10% frequency.[9]"

Tretinoin - Wikipedia
Does that sound like a cure to you?

Sounds to me like an generally destructive poison. Just like other chemotherapy treatments (including arsenic and compounds derived from mustard gas research).

And that's not even the full list of side effects of tretinoin.
Read the full list of side effects for yourself here: Wayback Machine
I've attached that as a PDF.

And yes, I learned all this from the basis of Genereux's research.
You do know that comparing the toxicity of a drug derived from a natural nutrient is not exactly using reason. Its like saying the cancers that Medroxyprogesterone acetate can cause will also be caused by progesterone. Simply not true but in fact it is mainstream wisdom to think so.
 

Amazoniac

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Well, this is the beauty of advancing medical research: Gerson damages patients with usual Vit A, Harold Manner and German oncologists (Manner learned everything from them) use emulsified Vit A in gigantic doses to cure some cancers and put in remission others.

You cannot argue with the facts.
I can argue that the title and original post can be misleading and perhaps they're better changed to all-trans retinoic acid since it's this active form that is doing the job. Otherwise most dietary vitamin A is already emulsified during absorption.

franko also has a good point: retinoic acid in excess is stressful. Even though delivering it emulsified allows distribution to the body, instead of concentrating the dose to the liver, it's just that the stress is dispersed so the toxicity is reduced but not absent at all: they're careful with effects of the sides that are similar to isotretinoin use. If cancer isn't just a localized problem, there must be better ways of dealing with it.
 
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burtlancast

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franko also has a good point: retinoic acid in excess is stressful.

franko a source of knowledge, lol ?

Are you posting again under the influence ?
 
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burtlancast

burtlancast

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:lol:
We'll sort them out, one at a time.
 
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