Emodin Has 5ar Inhibitor Properties, So Does Riboflavin

TreasureVibe

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Hey everyone, what do you think of this study? I accidently came across it:

5alpha-reductase inhibitory components as antiandrogens from herbal medicine. - PubMed - NCBI

5alpha-reductase inhibitory components as antiandrogens from herbal medicine.
Cho CH, et al. J Acupunct Meridian Stud. 2010.

Abstract
We investigated medicinal plant sources with 5alpha-reductase inhibitory activity. These compounds have been used in several remedies against androgen-dependent diseases including benign prostatic hyperplasia. The 50% ethanol extract of Polygonum multiflorum Thunb (Polygoni Multiflori Radix; Polygonaceae) showed potent 5alpha-reductase inhibitory activity. The fraction responsible for this activity was purified, and the active constituent was isolated and identified as emodin, an anthraquinone compound. Although emodin showed considerably less potent inhibitory activity than riboflavin, the inhibitory activity of the compound was more potent than that of alizarin (1,2-dihydroxyanthraquinone), an anthraquinone-type positive control. Also, anthraquinone itself was substantially inactive against 5alpha-reductase, in dicating that the hydroxyl group on the structure of emodin is an important structural moiety for displaying inhibitory activity.

Does this mean that emodin, which is in Cascara Sagrada as well, could induce Post Finasteride Syndrome or symptoms of it? The study also mentions riboflavin (vitamin B2) as having 5ar inhibitor properties apparently. Same question goes for vitamin B2, with regards to PFS.

Your opinions are valued!

@haidut What do you think of this?
 
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Regarding riboflavin:

Mechanism of 4-ene-steroid 5 alpha-reductase proton transfer in androgen target tissues. - PubMed - NCBI

Mechanism of 4-ene-steroid 5 alpha-reductase proton transfer in androgen target tissues
Together these findings demonstrate that FMN and FAD do not directly interfere with Gene-steroid Sa-reductase activity, but reconstitute an alternative process that converts NADPH to NADP+, a compound known to inhibit 4-ene-steroid Sa-reductase in a non-competitive manner[4]

[4] https://www.researchgate.net/public...roid_5_a-reductase_cholestenone_5_a-reductase

Maybe someone who understands this more could explain if this is relevant in actual living tissue?
 

baron

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I wonder if these studies, done on various popular substances, are only to fit the narrative of androgenic allopecia; so that some queer health influencer doesn't raise hell about it, like what happend with creatine.
 
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