Has anyone here with leaky gut taken aspirin and noticed a difference, good or bad? I want to try taking aspirin, but I have leaky gut syndrome and I really don't want to make it worse. I'm reading conflicting things about its effect on leaky gut, but most things seem to indicate that it can exacerbate it. If I'm understanding properly, it seems that even if it doesn't inflame the small intestine like other nsaids, it can decrease mucosal lining. Any thoughts or experiences that may enlighten me would be much appreciated!