haidut

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The bad news for the DHT-driven theory of prostate cancer just keep piling on. There have been at least 3 human trials in the last 5 years demonstrating that the direct injection of testosterone (T) into the prostate can stop advanced, inoperable prostate cancer. There are also studied showing DHT may prevent prostate cancer instead of causing it.
DHT Prevents Prostate Cancer And May Even Treat It
Another Confirmation That Testosterone Can Treat Prostate Cancer
Cancer "paradox": Testosterone Treats Prostate Cancer

Instead of admitting what is quite obvious at this point - that androgens not only do not cause but may actually treat prostate cancer - the medical industry in its desperation doubled-down on its claims and insisted that the benefits from T injection are due to the prostate converting the T into estrogen, and it is estrogen that was therapeutic. Estrogen has been used as part of the chemical castration approach to prostate cancer for decades, so the medical experts thought the public can be duped despite the fact that those same experts teach in medical school that the prostate is overwhelmingly a DHT-producing organ while expressing very little aromatase for estrogen synthesis. If I were to guess, a nightmare scenario for mainstream medicine depending on this theory for their employment would be a study showing that DHT itself is therapeutic in prostate cancer. As DHT cannot be aromatized into estrogen, that would effectively kill the credibility of the entire theory and hopefully the massive industry that depends on it.

Well, that is exactly what the study below did. It used a synthetic isomer of DHT known as Drostanolone (D) and tested it together with several of its metabolites against several cancer types.
Drostanolone - Wikipedia

The study found that both D and its metabolites had therapeutic effects against all the cancer types tested, including prostate cancer. In fact, D was actually found to be more potent against prostate cancer than the standard chemotherapeutic drug cisplatin. D is referred to in the study below as compound (1) and (9), which are the heptanoate ester and the base steroid respectively. As they say in the movies - "so much for the glory of Rome" :):

Bio-Catalytic Structural Transformation of Anti-cancer Steroid, Drostanolone Enanthate with Cephalosporium aphidicola and Fusarium lini, and Cytoto... - PubMed - NCBI

"...In conclusion, the microbial transformation of anabolic-androgenic steroid drostanolone heptanoate (1) with C. aphidicola and F. lini led to the synthesis of eight metabolites, including five new metabolites 2, 3, 6, 7, and 8. Hydroxylation, oxidative cleavage of ester moiety, reduction, and dehydrogenation were the main reactions observed during the transformation. Compounds 1–9 exhibited anti-cancer potential against HeLa (human cervical carcinoma), PC-3 (human prostate carcinoma), H460 (human lung cancer), and HCT116 (human colon cancer) cancer cell lines between moderate to potent range. Interestingly, substrate 1 (IC50 = 3.1 ± 3.2 μM) and metabolite 9 (IC50 = 2.8 ± 0.2 μM) were found to be more active against HCT116 cancer cell line than the standard drug, cisplatin (IC50 = 11.2 ± 3.0 μM). Compounds 1 (IC50 = 5.0 ± 1.2 μM), 3 (IC50 = 16.7 ± 2.6 μM), and 4 (IC50 = 12.4 ± 2.3 μM) were found to be more active against H460 cancer cell line than the standard drug, cisplatin (IC50 = 22.2 ± 2.1 μM). Metabolites 5 (IC50= 39.8 ± 1.5 μM), 8 (IC50 = 19.6 ± 1.4 μM), and 9 (IC50 = 25.1 ± 1.6 μM) were also found more active against HeLa cancer cell line than the standard drug, cisplatin (IC50 = 40.1 ± 2.0 μM). Metabolites 3 (IC50= 68.0 ± 1.2 μM), 4 (IC50 = 60.4 ± 0.9 μM), 6 (IC50 = 58.4 ± 1.6 μM), 7 (IC50 = 59.1 ± 2.6 μM), 8 (IC50 = 51.8 ± 3.4 μM), and 9 (IC50 = 57.8 ± 3.2 μM) were also found more active against PC-3 cancer cell line than the standard drug, cisplatin (IC50 = 76.5 ± 1.2 μM). Except compounds 8 and 9, all compounds were found to be non-cytotoxic to normal 3T3 cell line. These results indicated specific cytotoxicity of this class of compounds against cancer cell lines, as compared to normal cell line. Thus, the results of presented study will be helpful towards the drug discovery against cervical, prostate, lung, and colon cancers."
 
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This is a really cool study. Dr. Peat has mentioned that perhaps testosterone can help prostate cancer. But current medical practice is the opposite — with androgen deprivation therapy being the standard of care.

Thanks @haidut
 

LeeLemonoil

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Which is compound 9, the ester or unesterified D? It seems cytotoxic to some non-pathological cells.
 

haidut

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Which is compound 9, the ester or unesterified D? It seems cytotoxic to some non-pathological cells.

It was the base drostanolone.
"...Similarly, metabolite 9 (drostanolone) was also obtained through the biotransformation of compound 1. Drostanolone was used as a starting material for the synthesis of drostanolone propionate, and drostanolone enanthate (1), and other derivatives."
 
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Momado965

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@haidut when you mentiond drostanolone and said if you were to touch synthetic dht it would be drostanolone; did you mean methyldrostanolone or stanolone propoinate?
 

Momado965

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Aug 28, 2016
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While this post is on masteron. This vidoe about oxandrolone (anavar) is interesting. I didnt know anavar is metabolized in the kidneys. This last part about arterial health is a bit shocking since methyl groups affect the liver health primarily and only as far as I know but I guess they affect the arteries as well.

 
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