jzeno
Member
- Joined
- Nov 20, 2017
- Messages
- 543
Rare voice of reason
Studies cited
https://www.sciencedirect.com/science/article/pii/S0140673649907977
Can't find the second study
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Rare voice of reason
Studies cited
https://www.sciencedirect.com/science/article/pii/S0140673649907977
Can't find the second study
I think it makes perfect sense. I believe that diabetes is an infection, where endotoxins get absorbed into the bloodstream via chylomicrons when saturated fat is eaten. Take out the saturated fat, and you take out one of the pathways endotoxins enter the bloodstream.
Is Diabetes an Infection? A New Perspective on the Cause of Weight Gain and Type 2 Diabetes
Denise Minger wrote an excellent article on low fat diets:
In Defense of Low Fat: A Call for Some Evolution of Thought (Part 1)
It has less to do with avoiding saturated fat and more to do with lowering serum free fatty acids, the two aren't exactly linear. OP's video is by a biased YT channel featuring McDougall. McDougall is sort of riding on the coattails of Walt Kempner, the actual creator of the sugar and rice approach.I think it makes perfect sense. I believe that diabetes is an infection, where endotoxins get absorbed into the bloodstream via chylomicrons when saturated fat is eaten. Take out the saturated fat, and you take out one of the pathways endotoxins enter the bloodstream.
Is Diabetes an Infection? A New Perspective on the Cause of Weight Gain and Type 2 Diabetes
Denise Minger wrote an excellent article on low fat diets:
In Defense of Low Fat: A Call for Some Evolution of Thought (Part 1)
I think McDougall is right. High carb low fat diets will cure diabetes type 2. I don't think it has to be rice and sugar, but high carb low fat is what does it. I think due to the Randle effect. And this keeps free fatty acids very low. Free fatty acids are I think what causes diabetes.
Saturated fat doesn't cause diabetes, and even a fairly high intake of SFA won't impair carbohydrate metabolism as only PUFA inhibit the central enzymes involved in CHO metabolism (PDH, etc.). Again, look at babies - they get as many calories from fat as they get from carbs, and diabetes doesn't seem to be rampant among infants.
Distinctive roles of unsaturated and saturated fatty acids in hyperlipidemic pancreatitis
AIM: To investigate how the saturated and unsaturated fatty acid composition influences the susceptibility of developing acute pancreatitis.
METHODS: Primary pancreatic acinar cells were treated with low and high concentrations of different saturated and unsaturated fatty acids, and changes in the cytosolic Ca2+ signal and the expression of protein kinase C (PKC) were measured after treatment.
RESULTS: Unsaturated fatty acids at high concentrations, including oleic acid, linoleic acid, palmitoleic acid, docosahexaenoic acid, and arachidonic acid, induced a persistent rise in cytosolic Ca2+ concentrations in acinar cells. Unsaturated fatty acids at low concentrations and saturated fatty acids, including palmitic acid, stearic acid, and triglycerides, at low and high concentrations were unable to induce a rise in Ca2+ concentrations in acinar cells. Unsaturated fatty acids at high concentrations but not saturated fatty acids induced intra-acinar cell trypsin activation and cell damage and increased PKC expression.
CONCLUSION: At sufficiently high concentrations, unsaturated fatty acids were able to induce acinar cells injury and promote the development of pancreatitis. Unsaturated fatty acids may play a distinctive role in the pathogenesis of pancreatitis through the activation of PKC family members.
Low fat is essential to help the cells begin getting energy from oxidative phosphorylation.
The biggest factors are the individual's metabolic rate, age, and body composition. I'm of the personal opinion low(er) fat is probably better, but a much greater emphasis on PUFA and MUFA reduction rather than SFA. A high fat diet doesn't necessarily have to mean chronically elevated free fatty acids. Someone with low stress hormones, good thyroid function, and lots of lean mass could eat a high fat (saturated), high carb, diet without getting diabetic. High carb, low fat diets don't always mean low free fatty acids either, glucose conversion to pyruvate is good, glucose conversion to lactate is bad. Lactate is generally a byproduct of stress metabolism and elevated free fatty acids.
Yeah I agree to an extent. My total fat intake is around 15%, not that much. I eat around 2,700 calories a day so that approx 45 grams of total fat I eat everyday. Mostly from coconut oil, low fat dairy, cacao, and whatever is naturally present in the foods I eat. My PUFA intake is probably roughly around 1%, right on target with Dr. William Lands's recommendation.I'm starting to think that low fat in general is more important then stressing over which fat I am getting, I think they all are pretty bad in excess and that the small benefits of sfa for hormones are easily achieved with an egg or two each day.
This is just one I read recently, there are other older studies showing the same thing. Olive, soybean and palm oils intake have a similar acute detrimental effect over the endothelial function in healthy young subjects. - PubMed - NCBI
I think blood health is critical and that all fats basically contribute equally to hyper coagulation / lowering availability of oxygen and nutrients to the cells.
I'm starting to think that low fat in general is more important then stressing over which fat I am getting, I think they all are pretty bad in excess and that the small benefits of sfa for hormones are easily achieved with an egg or two each day.
This is just one I read recently, there are other older studies showing the same thing. Olive, soybean and palm oils intake have a similar acute detrimental effect over the endothelial function in healthy young subjects. - PubMed - NCBI
I think blood health is critical and that all fats basically contribute equally to hyper coagulation / lowering availability of oxygen and nutrients to the cells.
Yeah I agree to an extent. My total fat intake is around 15%, not that much. I eat around 2,700 calories a day so that approx 45 grams of total fat I eat everyday. Mostly from coconut oil, low fat dairy, cacao, and whatever is naturally present in the foods I eat. My PUFA intake is probably roughly around 1%, right on target with Dr. William Lands's recommendation.
Yeah I couldn't do low carb either, I developed pretty serious hyperventilation from low carb. I can only assume the decease in CO2 production was the cause. I think low carb also pushes a lot of inaccurate dogma about sugar being addictive. I never really craved sugar on low carb, not once. Eating all the steak, butter, and bacon I wanted was fine by me. I thought going low(er) fat was much harder than low carb, I craved the fatty foods at first, before I properly acclimated to the new diet. Even to this very day, I'll take steak and butter over sugar any day for taste preference. For me, fat seems a lot more addictive than sugar.I just decided today to move to 15%, I have been around 20-25% basically for no reason other than that I tend to like how food tastes with more fat, but I would rather feel my best than have a slightly tastier meal and feel so-so. I am sure I will adapt. I made the mistake of following a low carb, intermittent fasting diet, for about 5 years, and I am still paying for it. During that time I must have put on 20 pounds, some muscle but mainly fat.
Yeah I couldn't do low carb either, I developed pretty serious hyperventilation from low carb. I can only assume the decease in CO2 production was the cause. I think low carb also pushes a lot of inaccurate dogma about sugar being addictive. I never really craved sugar on low carb, not once. Eating all the steak, butter, and bacon I wanted was fine by me. I thought going low(er) fat was much harder than low carb, I craved the fatty foods at first, before I properly acclimated to the new diet. Even to this very day, I'll take steak and butter over sugar any day for taste preference. For me, fat seems a lot more addictive than sugar.
Actually it doesn't make any sense, at all. Saturated fat protects from endotoxin, and its' antibacterial properties reduce the amount of endotoxin in the gut very drastically.