Doxycycline Inhibits Cancer Stem Cell-Like Properties via PAR1/FAK/PI3K/AKT Pathway in Pancreatic Cancer

Orome

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The evidence accumulates that Doxycyline (and most likely Tetracylines in general) have a lot of beneficial effects beside the standard antibiotic. I for myself got particularly interested in it since it cured my very severe heartburn issues together with a chronic laryngitis from which I was suffering for more than a year. On some days I was even spitting blood because of it. 2 weeks of Doxycycline cured both and since then I never had an issue again. 100% symptom free now.
Obviously I was very happy about it but also very angry that something as simple and non-invasive could do the trick where dozens of doctor visits could not. The only thing the white coats could do was prescribe mega dosages of omeprazole which (of course) did nothing for my symptoms.

But anyway, this study indicates that Doxycycline could be also benefical for much more servere conditions:
Doxycycline Inhibits Cancer Stem Cell-Like Properties via PAR1/FAK/PI3K/AKT Pathway in Pancreatic Cancer


Abstract​

Pancreatic cancer stem cells (CSCs) play an important role in the promotion of invasion and metastasis of pancreatic cancer. Protease activation receptor 1 (PAR1) is closely related to malignant progression of tumors, however, its effects on pancreatic cancer stem cell-like (CSC-like) properties formation have not been reported. In this work, the effects of PAR1 on pancreatic cancer stem cell-like (CSC-like) properties formation were studied. PAR1 overexpression can induce CSC-like properties in Aspc-1 cells, whereas interference of PAR1 in Panc-1 cells showed the contrary results. Data on patients with pancreatic cancer obtained from TCGA showed that high PAR1 expression and focal adhesion kinase (FAK) protein considerably affect the prognosis of patients. Further experiments showed that PAR1 could regulate FAK, PI3K, and AKT phosphorylation and the epithelial-mesenchymal transformation (EMT) in Aspc-1 and Panc-1 cells. Doxycycline, as a PAR1 inhibitor, could effectively inhibit the CSC-like properties of pancreatic cancer cells and the FAK/PI3K/AKT pathway activation. Doxycycline inhibits the growth of pancreatic cancer and enhances the treatment effect of 5-fluorouracil (5-FU) in Panc-1 xenograft mouse model. In conclusion, PAR1 promotes the CSC-like properties and EMT of pancreatic cancer cells via the FAK/PI3K/AKT pathway. Doxycycline inhibits the pancreatic cancer through the PAR1/FAK/PI3K/AKT pathway and enhances the therapeutic effect of 5-FU.
 

Perry Staltic

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Doctors are slaves of big pharma and insurance companies. They knoweth not what they do. A doctor friend of mine, though, told me that if doxy were developed today it probably wouldn't be classified as an antibiotic.

Doxycycline is unique among the many tetracycline derivatives, in that it has a clear dosing split between its cellular cytotoxic/antimicrobial effects (>100 mg) and its potential anti-inflammatory/antiviral/pro-ionophoric effects (40 mg).3,4,7,8,12 This may be an important consideration for low-dose doxycycline (20 mg twice daily) as a potential prophylactic treatment against COVID-19 infection.

 

Orome

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Doctors are slaves of big pharma and insurance companies. They knoweth not what they do. A doctor friend of mine, though, told me that if doxy were developed today it probably wouldn't be classified as an antibiotic.




Fascinating - thanks for sharing.
About its benefical effects on corona virus I have also read a lot. But it's the same as with any other (potential) remedy which is NOT a vaccine. The effectiveness is downplayed and attempted to be refuted immediately (see other substances like Artemisia, Hydroxychloroquine...).

In Germany a major news outlet (which is funded by the government) recently published an article which said something like "A strong immune system is nice to have but totally useless for Covid. The only thing that can save you is the vaccine". And the fools (=readers) nodding this nonsense off just like that :doh
 
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