Dose-dependent Effect Of Copper Chloride On Male Reproductive Function

Douglas Ek

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Feb 8, 2017
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Hi guys!

So there are some studies showing that chelated copper increases Testosterone and I'm trying to figure out the optimal daily dosage for this.

Links to studies:
- Evidence that copper-amino acid complexes are potent stimulators of the release of luteinizing hormone-releasing hormone from isolated hypothalamic... - PubMed - NCBI
- Dose-dependent effect of copper chloride on male reproductive function in immature rats. - PubMed - NCBI

In the 2nd study, they inject copper chloride into the guts of the rats 1mg, 2mg or 3mg every day for 26 days. The 1mg dosage Quote: "significant increase in testicular steroidogenic enzyme activity and stimulation of testicular spermatogenesis along with a rise in serum testosterone and LH level were observed"

So I want to convert this into human dose. From what I've understood this would be an appropriate formula and please correct me if I'm wrong!

HED (mg/kg) = Animal Dose (mg/kg) x [Animal Km / Human Km]

Human Km = 37
Rat Km = 6

So basically 6/37 x 1mg/kg = 162mcg was close to the dose they used in the rats

My weight is 75 kg x 162mcg so that would amount to 12.15 mg of copper

The upper tolerable limit for copper is 10mg?

anyone thinks this seems reasonable?
 

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