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Dose-dependent Effect Of Copper Chloride On Male Reproductive Function

Douglas Ek

Feb 8, 2017
Hi guys!

So there are some studies showing that chelated copper increases Testosterone and I'm trying to figure out the optimal daily dosage for this.

Links to studies:
- Evidence that copper-amino acid complexes are potent stimulators of the release of luteinizing hormone-releasing hormone from isolated hypothalamic... - PubMed - NCBI
- Dose-dependent effect of copper chloride on male reproductive function in immature rats. - PubMed - NCBI

In the 2nd study, they inject copper chloride into the guts of the rats 1mg, 2mg or 3mg every day for 26 days. The 1mg dosage Quote: "significant increase in testicular steroidogenic enzyme activity and stimulation of testicular spermatogenesis along with a rise in serum testosterone and LH level were observed"

So I want to convert this into human dose. From what I've understood this would be an appropriate formula and please correct me if I'm wrong!

HED (mg/kg) = Animal Dose (mg/kg) x [Animal Km / Human Km]

Human Km = 37
Rat Km = 6

So basically 6/37 x 1mg/kg = 162mcg was close to the dose they used in the rats

My weight is 75 kg x 162mcg so that would amount to 12.15 mg of copper

The upper tolerable limit for copper is 10mg?

anyone thinks this seems reasonable?

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