Does Pregnenolone Supplementation Reduce Cholesterol?

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j.

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Claim: Pregnenolone lowers cholesterol. In one study, this hormone helped decrease subjects’ total cholesterol levels from 263 to 188.

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Couldn't find the study on the link.
 

charlie

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I would think anything that improves metabolism would help the body utilize cholesterol better. :2cents
 

cs3000

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I wonder about this, haven't seen ray peat mention anything which is odd considering the amount he used to take - and you'd think the body might reduce cholesterol if taking exogenous pregnenolone as no longer needs as much for this purpose . Considering the importance of cholesterol this is key to know

But these studies showing this https://www.google.com/url?q=https:...wQFnoECAkQAg&usg=AOvVaw1b0bz8w8R3FPtknkcsdsvQ

They all use loads of a combo of hormones, pregnenolone + testosterone or estrogen + cortisol + progesterone + DHEA. So it doesn't tell us what effect the pregnenolone has.
 
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"The cholesterol-lowering fiasco for a long time centered on the ability of unsaturated oils to slightly lower serum cholesterol. For years, the mechanism of that action wasn't known, which should have suggested caution. Now, it seems that the effect is just one more toxic action, in which the liver defensively retains its cholesterol, rather than releasing it into the blood. Large scale human studies have provided overwhelming evidence that whenever drugs, including the unsaturated oils, were used to lower serum cholesterol, mortality increased, from a variety of causes including accidents, but mainly from cancer.

Since the l930s, it has been clearly established that suppression of the thyroid raises serum cholesterol (while increasing mortality from infections, cancer, and heart disease), while restoring the thyroid hormone brings cholesterol down to normal. In this situation, however, thyroid isn't suppressing the synthesis of cholesterol, but rather is promoting its use to form hormones and bile salts. When the thyroid is functioning properly, the amount of cholesterol in the blood entering the ovary governs the amount of progesterone being produced by the ovary, and the same situation exists in all steroid-forming tissues, such as the adrenal glands and the brain. Progesterone and its precursor, pregnenolone, have a generalized protective function: antioxidant, anti-seizure, antitoxin, anti-spasm, anti-clot, anti-cancer, pro-memory, pro-myelination, pro-attention, etc. Any interference with the formation of cholesterol will interfere with all of these exceedingly important protective functions.

As far as the evidence goes, it suggests that coconut oil, added regularly to a balanced diet, lowers cholesterol to normal by promoting its conversion into pregnenolone. (The coconut family contains steroids that resemble pregnenolone, but these are probably mostly removed when the fresh oil is washed with water to remove the enzymes which would digest the oil.) Coconut-eating cultures in the tropics have consistently lower cholesterol than people in the U.S. Everyone that I know who uses coconut oil regularly happens to have cholesterol levels of about 160, while eating mainly cholesterol rich foods (eggs, milk, cheese, meat, shellfish). I encourage people to eat sweet fruits, rather than starches, if they want to increase their production of cholesterol, since fructose has that effect."

 

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