meatbag
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Would Mianserine increase Norepinephrine and/or Adrenaline In a similar manner to the Norephedrine-Dopamine Reuptake Inhibitors? (ex Bupropion)
From Wikipedia: (Mianserine) is classified as a noradrenergic and specific serotonergic antidepressant (NaSSA) and has antidepressant,anxiolytic (anti-anxiety), hypnotic (sedating), antiemetic (nausea and vomiting-attenuating), orexigenic (appetite-stimulating), and antihistamine effects.
"Mianserin is an antagonist/inverse agonist of the H1, 5-HT1D, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT6, 5-HT7, α1-adrenergic, and α2-adrenergic receptors,
BUT
and also inhibits the reuptake of norepinephrine."
Wouldn't this mean concentrations of norepinephrine would increase?
"Blockade of the H1 and α1-adrenergic receptors has sedative effects, and also antagonism of the 5-HT2A and α1-adrenergic receptors inhibits activation of intracellularphospholipase C (PLC), which seems to be a common target for several different classes of antidepressants. By antagonizing the somatodendritic and presynaptic α2-adrenergic receptors which function predominantly as inhibitory autoreceptors and heteroreceptors, mianserin disinhibits the release of norepinephrine, dopamine, serotonin, andacetylcholine in various areas of the brain and body."
So it's aganizing serotonin, histamine and adrenaline but increaseing noradrenaline?
Also I know its listed as rare but these are in the side effects and would seem to meet the criteria of reduced 5ar and increased Aromatase-
"Rare/very rare adverse effects include:
Noradrenaline (and Likely Adrenalin) Increases Estrogen
What I found from Peat on norepinephrine:
"While it's true that the thyroid hormone increases sensitivity to adrenaline, its most noticeable effect is in improving the ability to relax, including the ability to sleep soundly and restfully. And it happens that increasing norepinephrine (the brain's locally produced form of adrenaline) helps to prevent seizures (Giorgi, et al., 2004)."
-Water: swelling, tension, pain, fatigue, aging
"In hypothyroidism, thyrotropin-release hormone (TRH) is usually increased, increasing release of TSH. TRH itself can cause tachycardia, "palpitations," high blood pressure, stasis of the intestine, increase of pressure in the eye, and hyperventilation with alkalosis. It can increase the release of norepinephrine, but in itself it acts very much like adrenalin. TRH stimulates prolactin release, and this can interfere with progesterone synthesis, which in itself affects heart function."
-An Interview With Dr. Raymond Peat
So a good test if someone suspects increased Adrenaline/Noradrenaline and cortisol activity would be a test for TRH? Wouldn't this test give the same insight as TSH and Prolactin combined since it is what stimulates their release ( stimulates the release of thyrotropin (or TSH) and prolactin from the anterior pituitary?
From Wikipedia: (Mianserine) is classified as a noradrenergic and specific serotonergic antidepressant (NaSSA) and has antidepressant,anxiolytic (anti-anxiety), hypnotic (sedating), antiemetic (nausea and vomiting-attenuating), orexigenic (appetite-stimulating), and antihistamine effects.
"Mianserin is an antagonist/inverse agonist of the H1, 5-HT1D, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT6, 5-HT7, α1-adrenergic, and α2-adrenergic receptors,
BUT
and also inhibits the reuptake of norepinephrine."
Wouldn't this mean concentrations of norepinephrine would increase?
"Blockade of the H1 and α1-adrenergic receptors has sedative effects, and also antagonism of the 5-HT2A and α1-adrenergic receptors inhibits activation of intracellularphospholipase C (PLC), which seems to be a common target for several different classes of antidepressants. By antagonizing the somatodendritic and presynaptic α2-adrenergic receptors which function predominantly as inhibitory autoreceptors and heteroreceptors, mianserin disinhibits the release of norepinephrine, dopamine, serotonin, andacetylcholine in various areas of the brain and body."
So it's aganizing serotonin, histamine and adrenaline but increaseing noradrenaline?
Also I know its listed as rare but these are in the side effects and would seem to meet the criteria of reduced 5ar and increased Aromatase-
"Rare/very rare adverse effects include:
- Gynaecomastia — abnormal breast enlargement in males.
- Impotence
- Myalgia — muscle aches."
Noradrenaline (and Likely Adrenalin) Increases Estrogen
What I found from Peat on norepinephrine:
"While it's true that the thyroid hormone increases sensitivity to adrenaline, its most noticeable effect is in improving the ability to relax, including the ability to sleep soundly and restfully. And it happens that increasing norepinephrine (the brain's locally produced form of adrenaline) helps to prevent seizures (Giorgi, et al., 2004)."
-Water: swelling, tension, pain, fatigue, aging
"In hypothyroidism, thyrotropin-release hormone (TRH) is usually increased, increasing release of TSH. TRH itself can cause tachycardia, "palpitations," high blood pressure, stasis of the intestine, increase of pressure in the eye, and hyperventilation with alkalosis. It can increase the release of norepinephrine, but in itself it acts very much like adrenalin. TRH stimulates prolactin release, and this can interfere with progesterone synthesis, which in itself affects heart function."
-An Interview With Dr. Raymond Peat
So a good test if someone suspects increased Adrenaline/Noradrenaline and cortisol activity would be a test for TRH? Wouldn't this test give the same insight as TSH and Prolactin combined since it is what stimulates their release ( stimulates the release of thyrotropin (or TSH) and prolactin from the anterior pituitary?
