Tarmander
Member
- Joined
- Apr 30, 2015
- Messages
- 3,753
I have been messing around with cascara for the last couple weeks. It has been great for inflammation, getting rid of restless legs, obviously helping transit time, blood sugar stabilization, and even giving me feelings of calm.
However, I have been sick basically since I started it. I thought it was going to go away, but I have been hacking up phlegm, blowing my nose, and coughing non stop throughout the day. Tonight I noticed a cyst forming in my armpit that is painful and seems infected. I used to get those when I was a kid, and is a great sign to me that my immune system is suppressed.
I found this study: http://www.ncbi.nlm.nih.gov/pubmed/23811723
Here is the results part:
"RESULTS:
Emodin (1, 10, and 100 μmol/L) inhibited the growth of human T cells and induced apoptosis in dose- and time dependent manners. Emodin triggered ER stress and significantly elevated intracellular free Ca(2+) in human T cells. It also disrupted mitochondrial membrane potential, and increased cytosolic level of cytochrome C, and the levels of activated cleavage fragments of caspase-3, -4, and -9 in human T cells. Furthermore, emodin significantly increased the levels of ROS and MDA, inhibited both SOD level and GSH/GSSG ratio in human T cells, whereas co-incubation with the ROS scavenger N-acetylcysteine (NAC, 20 μmol/L) almost completely blocked emodin-induced ER stress and mitochondrial dysfunction in human T cells, and decreased the caspase cascade-mediated apoptosis.
CONCLUSION:
Emodin exerts immunosuppressive actions at least partly by inducing apoptosis of human T cells, which is triggered by ROS-mediated ER stress and mitochondrial dysfunction."
This study explains possible mechanisms of the immune suppression: http://www.ncbi.nlm.nih.gov/pubmed/20452342
Along with this one: http://www.ncbi.nlm.nih.gov/pubmed/19545739
Cascara seems to have some great effects but I can't be sick and tired all the time! Do its positive effects outweigh having a supresses immune system? After a couple weeks I'm leaning towards no.
However, I have been sick basically since I started it. I thought it was going to go away, but I have been hacking up phlegm, blowing my nose, and coughing non stop throughout the day. Tonight I noticed a cyst forming in my armpit that is painful and seems infected. I used to get those when I was a kid, and is a great sign to me that my immune system is suppressed.
I found this study: http://www.ncbi.nlm.nih.gov/pubmed/23811723
Here is the results part:
"RESULTS:
Emodin (1, 10, and 100 μmol/L) inhibited the growth of human T cells and induced apoptosis in dose- and time dependent manners. Emodin triggered ER stress and significantly elevated intracellular free Ca(2+) in human T cells. It also disrupted mitochondrial membrane potential, and increased cytosolic level of cytochrome C, and the levels of activated cleavage fragments of caspase-3, -4, and -9 in human T cells. Furthermore, emodin significantly increased the levels of ROS and MDA, inhibited both SOD level and GSH/GSSG ratio in human T cells, whereas co-incubation with the ROS scavenger N-acetylcysteine (NAC, 20 μmol/L) almost completely blocked emodin-induced ER stress and mitochondrial dysfunction in human T cells, and decreased the caspase cascade-mediated apoptosis.
CONCLUSION:
Emodin exerts immunosuppressive actions at least partly by inducing apoptosis of human T cells, which is triggered by ROS-mediated ER stress and mitochondrial dysfunction."
This study explains possible mechanisms of the immune suppression: http://www.ncbi.nlm.nih.gov/pubmed/20452342
Along with this one: http://www.ncbi.nlm.nih.gov/pubmed/19545739
Cascara seems to have some great effects but I can't be sick and tired all the time! Do its positive effects outweigh having a supresses immune system? After a couple weeks I'm leaning towards no.