In Nutrition for Women (p. 50) Peat mentions that biotin is known to cause fatty liver and so must be taken with inositol. This seemed curious to me, since advice on this forum had suggested that biotin will help reverse fatty liver. A quick google search yielded this article--http://www.jbc.org/content/141/2/619.full.pdf--according to which mice fed huge amounts of biotin, especially in conjunction with thiamine gained liver fat as well as overall body weight. Peat also mentioned that choline can reverse the effects of biotin--but not according to this article.
I hope someone more scientifically literate than myself might have some idea what to do about this (assuming its validity): stop taking biotin (~1.5/2 grams) and thiamine (~300 mg)? Take them separately? Add inositol? If so, how much? Is it safe to to take so much biotin in the long-term or is more of a short-term fix?
I hope someone more scientifically literate than myself might have some idea what to do about this (assuming its validity): stop taking biotin (~1.5/2 grams) and thiamine (~300 mg)? Take them separately? Add inositol? If so, how much? Is it safe to to take so much biotin in the long-term or is more of a short-term fix?