Does Aspirin Help To Convert T4 To T3?

milk_lover

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Ok sorry for asking many questions about Aspirin :D Does it help convert T4 to T3? The last couple of days with Aspirin experiment, I've noticed significant increases in body temperature and heart beat.
 

haidut

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milk_lover said:
post 102213 Ok sorry for asking many questions about Aspirin :D Does it help convert T4 to T3? The last couple of days with Aspirin experiment, I've noticed significant increases in body temperature and heart beat.

I don't know that it does increase conversion directly, but if it is helpful for the liver it will indirectly increase conversion of T4 into T3.
 
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milk_lover

milk_lover

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haidut said:
post 102227
milk_lover said:
post 102213 Ok sorry for asking many questions about Aspirin :D Does it help convert T4 to T3? The last couple of days with Aspirin experiment, I've noticed significant increases in body temperature and heart beat.

I don't know that it does increase conversion directly, but if it is helpful for the liver it will indirectly increase conversion of T4 into T3.

Do you think if Aspirin made a positive effect on me, at least for now, that might mean I have an impaired liver function to start with? Also I found two studies that talk about possible T4 to T3 conversion using Aspirin. What do you think of them?

http://www.ncbi.nlm.nih.gov/pubmed/760253
"Thyroid functions were studied in 11 patients with subacute thyroiditis accompanied by signs and symptoms of hyperthyroidism, and were compared with 13 patients with untreated thyrotoxicosis in which serum T4 was elevated to the identical level. Serum T3 was also elevated in subacute thyroiditis but to a significantly lower extent than in thyrotoxicosis. Therefore the ratio of T4/T3 was significantly higher in subacute thyroiditis than in thyrotoxicosis. Although duration of thyroid swelling was shorter in the group treated by prednisolone than by aspirin, the accelerated ESR, thyroid tenderness and fever subsided almost similarly in the two groups. Serum T4 and T3 levels declined more rapidly in treatment with prednisolone compared with aspirin. In patients treated by aspirin initial increase in T3 level occurred transiently with simultaneous decrease in the T4/T3 ratio. These changes suggest the increase in peripheral conversion of T4 to T3. Even in severe cases of subacute thyroiditis associated with hyperthyroidism, aspirin treatment is an effective therapy and there is no recurrence following withdrawal of the medication."

http://press.endocrine.org/doi/abs/10.1 ... m-43-1-107
"A double-blind study of the effect of two inhibitors of prostaglandin synthesis on the TRH stimulation of serum TSH and prolactin was carried out in 35 normal males. The subjects were evaluated before and after the administration of indomethacin or aspirin for one week. Both indomethacin and aspirin lowered plasma prostaglandin E and F levels significantly. Indomethacin treatment had no effect on the serum TSH or prolactin response to 100 μg TRH or the serum T3 and T4 levels. In contrast, aspirin treatment significantly decreased the serum TSH response to TRH and significantly lowered mean total serum T3 (RIA) and T4 (D). There was no effect on the prolactin response to TRH. These findings suggest that aspirin blocks TRH responsiveness by a mechanism other than the inhibition of prostaglandin synthesis, probably by its previously demonstrated effect on increasing the fraction of unbound thyroid hormone."
 
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haidut

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milk_lover said:
post 102229
haidut said:
post 102227
milk_lover said:
post 102213 Ok sorry for asking many questions about Aspirin :D Does it help convert T4 to T3? The last couple of days with Aspirin experiment, I've noticed significant increases in body temperature and heart beat.

I don't know that it does increase conversion directly, but if it is helpful for the liver it will indirectly increase conversion of T4 into T3.

Do you think if Aspirin made a positive effect on me, at least for now, that might mean I have an impaired liver function to start with? Also I found two studies that talk about possible T4 to T3 conversion using Aspirin. What do you think of them?

http://www.ncbi.nlm.nih.gov/pubmed/760253
"Thyroid functions were studied in 11 patients with subacute thyroiditis accompanied by signs and symptoms of hyperthyroidism, and were compared with 13 patients with untreated thyrotoxicosis in which serum T4 was elevated to the identical level. Serum T3 was also elevated in subacute thyroiditis but to a significantly lower extent than in thyrotoxicosis. Therefore the ratio of T4/T3 was significantly higher in subacute thyroiditis than in thyrotoxicosis. Although duration of thyroid swelling was shorter in the group treated by prednisolone than by aspirin, the accelerated ESR, thyroid tenderness and fever subsided almost similarly in the two groups. Serum T4 and T3 levels declined more rapidly in treatment with prednisolone compared with aspirin. In patients treated by aspirin initial increase in T3 level occurred transiently with simultaneous decrease in the T4/T3 ratio. These changes suggest the increase in peripheral conversion of T4 to T3. Even in severe cases of subacute thyroiditis associated with hyperthyroidism, aspirin treatment is an effective therapy and there is no recurrence following withdrawal of the medication."

http://press.endocrine.org/doi/abs/10.1 ... m-43-1-107
"A double-blind study of the effect of two inhibitors of prostaglandin synthesis on the TRH stimulation of serum TSH and prolactin was carried out in 35 normal males. The subjects were evaluated before and after the administration of indomethacin or aspirin for one week. Both indomethacin and aspirin lowered plasma prostaglandin E and F levels significantly. Indomethacin treatment had no effect on the serum TSH or prolactin response to 100 μg TRH or the serum T3 and T4 levels. In contrast, aspirin treatment significantly decreased the serum TSH response to TRH and significantly lowered mean total serum T3 (RIA) and T4 (D). There was no effect on the prolactin response to TRH. These findings suggest that aspirin blocks TRH responsiveness by a mechanism other than the inhibition of prostaglandin synthesis, probably by its previously demonstrated effect on increasing the fraction of unbound thyroid hormone."

Can you move these to a separate thread please? This is a thread about pregnenolone/progesterone.
 
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milk_lover

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:D Sorry I didn't mean to hijack the thread. I thought they are related somehow because they can both convert T4 to T3. But yeah I might write a separate thread later.
 

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