This:
Aspirin Activates AMPK - But What's the Minimum Effective Dose? - Supplements - LONGECITY
Some people, including me, got permanent tinnitus (mine increased) from aspirin. This substance is a known ototoxin, so why it's still being promoted here?
Aspirin Activates AMPK - But What's the Minimum Effective Dose? - Supplements - LONGECITY
For what it's worth, regular intake of aspirin (and ibuprofen & acetaminophen) have recently been associated with permanent hearing loss, particularly in males and often at a young age.
https://www.ncbi.nlm...les/PMC2831770/
"During 369,079 person-years of follow-up, 3488 incident cases of hearing loss were reported. Regular use of each analgesic was independently associated with an increased risk of hearing loss. Multivariate-adjusted hazard ratios of hearing loss in regular users (2+ times/week) compared with men who used the specified analgesic <2 times/week were 1.12 (95% CI, 1.04–1.20) for aspirin, 1.21 (95% CI, 1.11–1.33) for NSAIDs, and 1.22 (95% CI, 1.07–1.39) for acetaminophen. For NSAIDs and acetaminophen, the risk increased with longer duration of regular use. The magnitude of the association was substantially higher in younger men. For men younger than age 50, the hazard ratio for hearing loss was 1.33 for regular aspirin use, 1.61 for NSAIDs, and 1.99 for acetaminophen.
Conclusions
Regular use of aspirin, NSAIDs, or acetaminophen increases the risk of hearing loss in men and the impact is larger on younger individuals.
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My girlfriend has taken an aspirin/acetaminophen/caffeine pain reliever fairly regularly for the last 30 years and now has substantial hearing loss that has seriously affected her life. I sometimes tease her about how many times she'll say "huh, what" during normal conversation, even in a quiet room. She also startles quite easily. She can't hear me moving around the house and about jumps out of her shoes when she comes around a corner and sees me in a room she isn't expecting to find me. She no longer appreciates music, & can't even hear something boiling over on the stove if she's not in the kitchen.
I've always shunned pain meds as they wreck my gut, and my hearing is so acute I can tell where the cat is sleeping at night as I can hear it breathing. This after attending dozens of rock concerts throughout the 70s, 80s & 90s, & smoking for over 40 years.
You never realize just how much mild to moderate hearing loss can truly affect quality of life unless you've lived with someone who can no longer hear even normal conversation. Something to consider when thinking about long term / regular use of ototoxic substances.
Some people, including me, got permanent tinnitus (mine increased) from aspirin. This substance is a known ototoxin, so why it's still being promoted here?