- Jul 24, 2012
I've found some evidence that high-fat diets can increase fasting serum FFA, but surprisingly little on the effect of low-fat diets.
Any insight on this?
Any insight on this?
jag2594 said:Not always. High estrogen, growth hormone, and prolactin can increase free fatty acids. So basically being stressed will elevated free fatty acids even with a low fat diet.
Kasra said:I've found some evidence that high-fat diets can increase fasting serum FFA, but surprisingly little on the effect of low-fat diets.
jyb said:jag2594 said:Not always. High estrogen, growth hormone, and prolactin can increase free fatty acids. So basically being stressed will elevated free fatty acids even with a low fat diet.
Release of FFA in times of stress doesn't serve the same role as fasting FFA (emergency response vs energy supply). The diet will decide the amount of latter I'm guessing, it's a choice you make depending on what foods or supplements you take, but I'm not sure about the former.
Recent papers are reporting that the estrogen used to "treat menopause" causes an increase in free fatty acids. Spellacy and Carlson suggested that estrogen's effect was mediated by growth hormone, and that is now the consensus. Women are much more likely than men to develop diabetes.
Estrogen increases secretion of growth hormone (GH; it's closely associated with prolactin, also increased by estrogen), and GH causes an increase in free fatty acids in the blood. Estrogen promotes iron retention, so it sets the stage for oxidative stress. At least in some systems, both estrogen and PUFA promote the entry of calcium into the cell.
Since stress increases the amount of free fatty acids circulating in the blood (as well as lipid peroxides), and since lack of oxygen increases the intracellular concentration of free fatty acids, stored unsaturated fats would seem to represent a special danger to the stressed organism.
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