Do You Try To Avoid Advanced Glycation End-product?

[cs3000]

Any natural inhibitors about it? so milk, yogurt and cheese have less impact?

reading a chris masterjohn post dietary AGEPs don't look like a big deal for the most part. most of them come from within the body

ensuring adequate zinc & glutathione (selenium) should cover it

Treatments that deplete cells (27) or live animals (28) of their glutathione cause large increases in methylglyoxal concentrations, suggesting that the glyoxalase system is ordinarily efficiently detoxifying much or most of the methylglyoxal that crosses its path. Little is known about the molecular mechanisms by which our cells regulate their production of the two glyoxalase enzymes themselves, but we know so far that zinc and insulin increase the production of glyoxalase-1 (29). This suggests that zinc, insulin, and glutathione are critical components of our defense against dicarbonyls and the AGEs they produce.

 

[Motorneuron]

reading a chris masterjohn post dietary AGEPs don't look like a big deal for the most part. most of them come from within the body

ensuring adequate zinc & glutathione (selenium) should cover it

Treatments that deplete cells (27) or live animals (28) of their glutathione cause large increases in methylglyoxal concentrations, suggesting that the glyoxalase system is ordinarily efficiently detoxifying much or most of the methylglyoxal that crosses its path. Little is known about the molecular mechanisms by which our cells regulate their production of the two glyoxalase enzymes themselves, but we know so far that zinc and insulin increase the production of glyoxalase-1 (29). This suggests that zinc, insulin, and glutathione are critical components of our defense against dicarbonyls and the AGEs they produce.

Very interesting, what do you think about using, for example, 10 injections of pure Glutathione every two months? they are 600mg vials. Or could bypassing its natural production create more problems within the methylation cycle and the liver?