Elize
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- Joined
- Jan 25, 2016
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Hans Thanks. Would high salt reduce cortisol? I tried an adrenal cocktail with lots of Salt and Orange juice and became jittery. I wake up around 12 pm and again at 3 am every night/morning.
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I have in the past, but not anymore. But I will do it again soon as part of a T boosting protocol.@Hans
Thanks for the reply.
And do you follow this aspirin regimen now or a similar variation or have you in the past?
Thank you
Im trying to do it daily. In the beginning I wasnt able to cope with side effect daily so its was some thing like 1 day and after 2 days off. The worst and seems to me the only noticeable was lactate overaccumulation even with addition of b1 250mg. After starting bag breathing and baking soda this issue is virtually non existing even if I stay uncoupled 24/7.
Doses of 300 to 650 mg of aspirin have a half-life of 3.1 to 3.2 hours. Doses of 1 gram have a half-life of 5 hours and with 2 grams it is increased to about 9 hours.
From Aspirin Comparable To DNP As Mitochondrial Uncoupler
"oral doses of aspirin needed to achieve the optimal concentration of 0.5mM (as shown on the image and other studies) are in the range of 1,000mg-1,500mg as a loading first dose, followed by 500mg every 4-6 hours."
So you'll have to take higher doses yes. But when adding other uncouplers like stearic acid, caffeine, methylene blue, sodium benzoate, etc., you might need less.
Oh yes and forgot to add. It's to be taken daily.
Yes it's uncoupler, that's why it's used in oxidal :). Apparently, it only uncouples at low dose and not at high dose. Seemingly, the best dose for uncoupling is around 6-8mg daily. Oxidal - Liquid Mix Of MB, Caffeine And Benzoic AcidAny info about uncoupling effect of sodium benzoate/benzoic acid? I didnt know it is an uncoupler. I use it to lower ammonia. Seem to lift the brain fog.
Salt should help lower cortisol yes, but if the elevated cortisol is not due to low salt intake, salt might not lower it all that effective. Waking up regularly is just a sign of bad glycogen storage. Do you eat enough? Have you done some blood tests for thyroid?Hans Thanks. Would high salt reduce cortisol? I tried an adrenal cocktail with lots of Salt and Orange juice and became jittery. I wake up around 12 pm and again at 3 am every night/morning.
Add some stearic acid when using the C60. Those two go synergistically together, plus stearic acid is also an uncoupler and improves mitochondrial fusion and function. If you can tolerate caffeine, take some as that will also increase temps. And then finally, you can add in some methylene blue to improve cellular function and uncoupling.@methylenwhite @Hans
Thanks for the tip on the 1 g of Aspirin
Before, as I said, I was taking about 81 mg cut from a whole tab of 325 mg by cutting a whole 325 tab down into quarters and taking those once per day.
Yesterday, I tried taking 3 325 mg tabs ground up (totally just shy of 1 g) and dissolved in some OJ and water (just what I threw into a cup, I don't know why). Immediately after I took the aspirin my ankles finally warmed up after weeks of dealing with cold-ish ankles but warm enough hands and feet. After my ankles warmed, my toes felt cold. I don't know why that is. I didn't like it very much. After the initial reaction, later in the evening, I did not feel good; I felt cold and miserable. I don't think the aspirin had anything to do with that but it could have been a reaction.
This morning, with breakfast I took 3 325 mg crushed and somewhat dissolved tabs in water with breakfast (cheese with toast) and my temperature rose slightly from 98.3 F to 98.6 F. This could be some sort of sign I'm on the right track.
My goal is to hit a comfortable 98.4-98.6 F without cold hands and feet or ankles. Same goal as everyone else I suppose.
Right now, hot showers are the best thing to raise my body temperature. I take one upon rising which boosts my temperature from my rising temperature of 97.7 F to 98.3-98.6 F. Then I take one 1.5 hours before bed (usually at 9 PM). With breakfast, I'll continue to take 1 g of aspirin until I start to see any adverse reactions. I make take a day off here and there to gauge my response without 1 g of aspirin.
I also purchased some C60. We'll see how that goes.
All I want is to stop feeling cold. It's miserable. Ugh.
Thanks for your input guys.
Is it 6-8mg of benzoic acid or sodum benzoate?Yes it's uncoupler, that's why it's used in oxidal :). Apparently, it only uncouples at low dose and not at high dose. Seemingly, the best dose for uncoupling is around 6-8mg daily. Oxidal - Liquid Mix Of MB, Caffeine And Benzoic Acid
Benzoic acid.Is it 6-8mg of benzoic acid or sodum benzoate?
What dose of sodium benzoate equals 6-8mg of benzoic acid? Is it even possible to substitute benzoic acid by sodium benzoate?Benzoic acid.
@methylenwhite @Hans
Thanks for the tip on the 1 g of Aspirin
Before, as I said, I was taking about 81 mg cut from a whole tab of 325 mg by cutting a whole 325 tab down into quarters and taking those once per day.
Yesterday, I tried taking 3 325 mg tabs ground up (totally just shy of 1 g) and dissolved in some OJ and water (just what I threw into a cup, I don't know why). Immediately after I took the aspirin my ankles finally warmed up after weeks of dealing with cold-ish ankles but warm enough hands and feet. After my ankles warmed, my toes felt cold. I don't know why that is. I didn't like it very much. After the initial reaction, later in the evening, I did not feel good; I felt cold and miserable. I don't think the aspirin had anything to do with that but it could have been a reaction.
This morning, with breakfast I took 3 325 mg crushed and somewhat dissolved tabs in water with breakfast (cheese with toast) and my temperature rose slightly from 98.3 F to 98.6 F. This could be some sort of sign I'm on the right track.
My goal is to hit a comfortable 98.4-98.6 F without cold hands and feet or ankles. Same goal as everyone else I suppose.
Right now, hot showers are the best thing to raise my body temperature. I take one upon rising which boosts my temperature from my rising temperature of 97.7 F to 98.3-98.6 F. Then I take one 1.5 hours before bed (usually at 9 PM). With breakfast, I'll continue to take 1 g of aspirin until I start to see any adverse reactions. I make take a day off here and there to gauge my response without 1 g of aspirin.
I also purchased some C60. We'll see how that goes.
All I want is to stop feeling cold. It's miserable. Ugh.
Thanks for your input guys.
Edit: Morning temperature after breakfast and 1 g of aspirin rose slightly from 98.3 to 98.6 F.
Afternoon oral temperature 15 minutes after eating lunch is 98.8 F. Ankles are still chilly--but slightly better. Not sure what the issue is, but at least I'm making progress with the core temp by upping aspirin to 1 g.
Glad your doing better. You can take a bit of bicarb with the aspirin to prevent any negatives on the stomach. It would also be good to take some glycine, vit C (aspirin reduces vit c in the gut. OJ would probably be enough if you drink a fair amount of it daily), and K2 (1mg K2 for every 325mg aspirin) on the same days as taking aspirin. If you do want to scale back on the aspirin in the future, you can add other uncouplers too.@Hans @methylenwhite
Update:
Saturday, I took 1 g of aspirin and by the end of the day my temp. dropped to 97.7 F like it has been for the recent past, but I felt really cold. However, I concluded I don't think this had to do with the aspirin and it might have just been something else that I did or didn't do.
Sunday, I took 1 mg of aspirin in the morning with breakfast, then I took about 500 mg of aspirin (1.5 325 mg tablets) 6 hours later (per your guys' suggestion) and I felt better but my temp still dropped to approx. 97.7 F in the evening but I didn't feel particularly cold like I did yesterday. I did everything the same: morning shower upon rising, breakfast, lunch, 30 minute walk for exercise, dinner, and evening shower 1.5 hours before bed.
Monday, I took 1 g of aspirin in the morning, another approx 500 mg of aspirin 6 hours later, then I took another 650 mg right before bed (2 325 mg tablets). The results were very good. Today (Tuesday morning), upon rising my temperature was 98.3 F as soon as I got up out of bed and it hasn't dropped at all once and I feel so warm and my heart is pounding very strong while I do light chores around the house. My temp rose to 98.9 F after cleaning my bathroom (scrubbing, moving around, nothing intense). Wow.
Today (Tuesday), I plan on taking a lot more aspirin and I guess see what happens. I heard the recommendation somewhere (maybe it was Ray) that I should take something until symptoms disappear and no more, implying not to take any more than what's needed by taking an amount until the symptoms disappear and titrate downward until the symptoms appear and take just above that amount. So I guess I'm going to experiment with a regularly administered dose and see what I need in order to hover around 98.3 F throughout the day.
Anything to stop my ankles and feet from feeling cold! Yeesh.
My only concern is aspirin at this dose might be detrimental, but I have no idea. There is a lot of conflicting research on aspirin and it's quite confusing, so I'm trying to wade through the research now to reduce risk.
Thanks again guys for the suggestion.
I can't say if this will work for everyone--to raise their temp.--but this, so far, has been very effective and has addressed whatever was causing my temp to hover so low despite whatever I did to adjust my diet (reducing PUFA, drinking coffee, adding in tons of milk, cheese, and OJ, etc.).
I have done some things in the past that eventually stopped working after time. I'm not sure if this will be the same, but I may provide an update if I feel like an update is warranted if the effect changes for the better or worse.
For now, I will say to others reading this thread: If you have a temp. issue, consider experimenting with larger than typical aspirin doses.
It should also be stated that, I read the Directions on my aspirin bottle and even taking 2,150 mg of aspirin, or 2.15 g, (3 325 mg tablets in the AM, 1.5 325 mg tablets in the PM, and 4 325 mg tablets in the evening), I was still well within the recommended amount per the official Directions for Use on the bottle. The Directions for Use state that one shouldn't take more than 12 325 mg tablets per 24 hours. I took the equivalent of 6 tablets in a 24-hour period. So, still within safe measures even according to the official Directions for Use (for those who care to know).
Even then, I think that amount--12 325 mg tablets in a 24-hour period--is conservative and you could probably get away with taking more, but please be careful if you do decide to do this. Just take it slow and titrate up cautiously to be on the safe side.
Also: I didn't experience any stomach discomfort at all or any other side effects.
For now, I will continue experimenting with moderate amounts of regularly dosed aspirin.
Thanks again guys. I'll provide another update if warranted or when enough time passes to confirm if I'm still getting the same effect.