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Who are you referring to? In my personal life, I don't know of anyone who supplements K2, other than myself (and I have been using it for a decade). I don't have issues with cavities or heart disease, but don't think those are usually a concern for men at my age, either. All the people I know who had some form of heart disease (or other degenerative diseases) hadn't even heard of K2. Same with cavities.
Vitamin K2 seems quite easy to modify, creating a unique (patentable) formulation for co-administration with statins. It's absurd and very pernicious, because the prescription of drugs continues anyway, actually strengthened by this pseudo-homeostasis concept. A drug for a drug for a drug. I know a man in this situation, who stubbornly refuses safe lipid-lowering alternatives like thyroid hormone or glycine, but is open to using K2 as a risk-reducer.As other users already mentioned, most people in that trial were on statins. Statins are actually known to increase vascular calcification, so I am not even sure how they are still prescribed as "therapy" for CVD, but that is a separate topic. Assuming MK-7 and vitamin D worked, this trial actually showed that those vitamins managed to block the pro-calcification effects of statins - i.e. the overall effects on calcification was null, despite the usage of pro-calcification statins. Yay!
In addition, MK-7 is not the form usable by the human body, as other users also mentioned. Its long side chain will have to get cleaved a few times and eventually get shortened to become MK-4. So, since MK-7 is administered in microgram (mcg) amounts, at best you'd be getting mcg amounts of MK-4 as a metabolite. However, in order for MK-4 to have an effect on bone resorption, human studies have shown that at least ~1mg daily is needed, and at least 5mg daily are needed for optimal effect.
"...Fifteen healthy males aged 25.0 years (median) participated in a non-placebo-controlled dose-examination study. They received menaquinone-4 daily for 5 weeks at 0, 300, 600, 900, and 1500 μg/day in weeks 1, 2, 3, 4, and 5, respectively. Compared with baseline, serum γ-carboxylated osteocalcin levels were significantly greater at an intake of 900 μg/day or more;..."
Low-dose menaquinone-4 improves γ-carboxylation of osteocalcin in young males: a non-placebo-controlled dose–response study - Nutrition Journal
Background Menaquinone-4 is a type of vitamin K that has a physiological function in maintaining bone quality via γ-carboxylation of osteocalcin. However, little is known about the beneficial effect of intake of dosages below1500 μg/day. Findings Fifteen healthy males aged 25.0 years (median)...nutritionj.biomedcentral.com
So, with the MK-7 administration of mcg amounts in this study getting mg amounts of MK-4 is impossible. I still view the study results as good though. We now know that vitamin K can prevent the calcification effects of statinsThe bad news is that Big Pharma will stop at nothing in its quest to bash effective, OTC therapies while the real villain is its own toxic drugs (statins in this case). Just a few months ago they were again bashing aspirin, while the real culprit were the blood-thinners aspirin often gets co-administered with.
@tankasnowgod @Ras @EvanHinkle @crazypatriot @competentmouser
Statins Accelerate Coronary Calcification and Reduce the... : Cardiology in Review
en accelerate progression of CAC; meanwhile, some researchers demonstrate opposite results. With the purpose of seeking out the effect of statin therapy on CAC, we summarized the existing evidence on statins and undertook meta-analyses of clinical trials assessing the effect of statin therapy on...journals.lww.com
Plaque Paradox: Statins Increase Calcium in Atheromas Even as They Shrink Them
A Cleveland Clinic analysis of IVUS images from eight large clinical trials suggests that coronary artery calcification might in fact be cardioprotective. We explore implications for research and practice.consultqd.clevelandclinic.org
Progression of Vascular Calcification Is Increased With Statin Use in the Veterans Affairs Diabetes Trial (VADT)
OBJECTIVE. To determine the effect of statin use on progression of vascular calcification in type 2 diabetes (T2DM).RESEARCH DESIGN AND METHODS. Progressiodiabetesjournals.org
Statins May Contribute to Vascular Calcification by Inhibiting Vitamin K-Dependent Proteins
Researchers suggest the finding may open up inquiries on vitamin K2 supplementation for statin patients.www.nutraceuticalsworld.com
Well, you can't "debunk" a man, so this claim isn't even relevant. If you have issues with some of his claims, that's another issue. Nobody gets anything 100% right. And just because he may have been mistaken about some things, or didn't have everything complete, that doesn't mean he has NOTHING valid to offer.
You don't know that. There are 8 billion plus people in the world, and you haven't done case studies on all 8 billion of them.
You also don't seem to understand that there is a difference between the man (who is no longer alive), the foundation named after him, and Green Pastures, which is a company that has no official affiliation with either the man, or the foundation.
That is, do you think that K2 MK7 should be taken in milligrams?As other users already mentioned, most people in that trial were on statins. Statins are actually known to increase vascular calcification, so I am not even sure how they are still prescribed as "therapy" for CVD, but that is a separate topic. Assuming MK-7 and vitamin D worked, this trial actually showed that those vitamins managed to block the pro-calcification effects of statins - i.e. the overall effects on calcification was null, despite the usage of pro-calcification statins. Yay!
In addition, MK-7 is not the form usable by the human body, as other users also mentioned. Its long side chain will have to get cleaved a few times and eventually get shortened to become MK-4. So, since MK-7 is administered in microgram (mcg) amounts, at best you'd be getting mcg amounts of MK-4 as a metabolite. However, in order for MK-4 to have an effect on bone resorption, human studies have shown that at least ~1mg daily is needed, and at least 5mg daily are needed for optimal effect.
"...Fifteen healthy males aged 25.0 years (median) participated in a non-placebo-controlled dose-examination study. They received menaquinone-4 daily for 5 weeks at 0, 300, 600, 900, and 1500 μg/day in weeks 1, 2, 3, 4, and 5, respectively. Compared with baseline, serum γ-carboxylated osteocalcin levels were significantly greater at an intake of 900 μg/day or more;..."Low-dose menaquinone-4 improves γ-carboxylation of osteocalcin in young males: a non-placebo-controlled dose–response study - Nutrition Journal
Background Menaquinone-4 is a type of vitamin K that has a physiological function in maintaining bone quality via γ-carboxylation of osteocalcin. However, little is known about the beneficial effect of intake of dosages below1500 μg/day. Findings Fifteen healthy males aged 25.0 years (median)...
So, with the MK-7 administration of mcg amounts in this study getting mg amounts of MK-4 is impossible. I still view the study results as good though. We now know that vitamin K can prevent the calcification effects of statins
@tankasnowgod @Ras @EvanHinkle @crazypatriot @competentmouser
Statins Accelerate Coronary Calcification and Reduce the... : Cardiology in Review
en accelerate progression of CAC; meanwhile, some researchers demonstrate opposite results. With the purpose of seeking out the effect of statin therapy on CAC, we summarized the existing evidence on statins and undertook meta-analyses of clinical trials assessing the effect of statin therapy on...Plaque Paradox: Statins Increase Calcium in Atheromas Even as They Shrink Them
A Cleveland Clinic analysis of IVUS images from eight large clinical trials suggests that coronary artery calcification might in fact be cardioprotective. We explore implications for research and practice.Progression of Vascular Calcification Is Increased With Statin Use in the Veterans Affairs Diabetes Trial (VADT)
OBJECTIVE. To determine the effect of statin use on progression of vascular calcification in type 2 diabetes (T2DM).RESEARCH DESIGN AND METHODS. ProgressioStatins May Contribute to Vascular Calcification by Inhibiting Vitamin K-Dependent Proteins
Researchers suggest the finding may open up inquiries on vitamin K2 supplementation for statin patients.www.nutraceuticalsworld.com
