Sex difference in pathology of the ageing gut mediates the greater response of female lifespan to dietary restriction
Here are some clues about the real mechanisms behind the benefits.
Imo the difference is entirely due to their difference in serum iron and would be normalized with regular phlebotomy. Iron counteracts on those protective mechanisms.
Iron deprivation results in an increase in p53 expression. - PubMed - NCBI
(p53 = tumor supressor lost in cancer)
Dietary restriction reduces hepatocyte proliferation and enhances p53 expression but does not increase apoptosis in normal rats during development. - PubMed - NCBI
TLDR : Iron reduces p53, dietary restriction enhances p53.