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Dietary Restriction Reduces Gut Pathology In Aging Females

  1. Imo the difference is entirely due to their difference in serum iron and would be normalized with regular phlebotomy. Iron counteracts on those protective mechanisms.

    Iron deprivation results in an increase in p53 expression. - PubMed - NCBI
    (p53 = tumor supressor lost in cancer)

    Dietary restriction reduces hepatocyte proliferation and enhances p53 expression but does not increase apoptosis in normal rats during development. - PubMed - NCBI

    TLDR : Iron reduces p53, dietary restriction enhances p53.
     
  2. Interesting!