Dietary PUFA In Childhood Causes Diabetes And Irreversible (male) Infertility


Mar 18, 2013
USA / Europe
A great study, which corroborates the discussion in another recent post of mine on PUFA's role in infertility and insulin-resistance / diabetes. However, the study below found that the infertility caused by dietary PUFA exposure were NOT reversible upon discontinuation of the high-fat (both PUFA and MUFA) diet, while previous studies found that the infertility was reversible. I think the reason for the discrepancy was that previous studies targeted specifically PUFA reduction in the diet to restore fertility, while the current study simply lowered the amount of fat in diet, but there was still a sufficient amount of PUFA left in the diet to prevent restoration of fertility. On a bit of conspiracy tangent - when I first saw the popular press article (10/23/2020) it clearly stated that the infertility issues were characterized/caused by accumulation of PUFA in testes. However, as of today (10/26/2020) the references to the infertility-causing effects of PUFA have all been removed from the press article and can only be found in the actual study, which, of course, most members of the general public will not read. This level of manipulation and (mis)reporting on the findings of a scientific study should be criminalized!

Since we can no longer rely on the popular press to report the truth, I extracted the relevant quotes from the study itself so that it becomes clear that the message of the study authors themselves is that it was the high PUFA in the diet that was detrimental for both insulin sensitivity and fertility. Saturated fat (SFA) was found to have a positive effect on fertility and was found to accumulate ONLY in the gonads of fertile animals. Interestingly, MUFA were also found to accumulate in the gonads of infertile animals, likely because the gonads of the high-fat diet animals were able to synthesize PUFA from MUFA through overexpression of de-saturase enzymes. Finally, event though the goal of this study was to test the long-term fertility effects of a high-PUFA diet fed in childhood, there is nothing in the study that prevents the same outcome in adult fed a high-PUFA diet. Also, there is no reason why the findings of this study apply to males only. High-fat (PUFA) diet causes PUFA accumulation just as easily in ovaries as it does in testes. IMO, the epidemic of infertility among Millenials is a corroboration of that hypothesis. The majority of that generation was almost entirely formula-fed and baby formula has a PUFA composition that is even worse than the high-fat diet in this experiment.

"...After grouping FAs by degree of unsaturation and the position of the double bonds (Table S5 and Figure 4), we observed that the most abundant FA family in the testis of CTRL and HFDt groups are the saturated fatty acids (SFAs) (55.79% and 41.83%, respectively), while polyunsaturated fatty acids (PUFAs) are the most abundant in the testis of mice from the HFD group (44.21%). HFD and HFDt mice had also increased testicular relative abundance of monosaturated fatty acids (MUFAs) (26% and 21%, respectively), with increased accumulation of oleic acid (C18:1n-9). Moreover, Table S5 also shows indirect measures for the anti-inflammatory/pro-inflammatory potential via lipid mediators (C22:6n-3/C20:4n-6 ratio), the combined activity of Δ5- and Δ6-desaturases (D5D and D6D) (C20:4n-6/C18:2n-6 ratio), and the activity of Δ4-desaturases (D4D) (C22:5n-6/C20:4n-6 ratio)."

"...In our previous work (12), we also reported reduced sperm quality which was associated with fat deposition. Moreover, there is a decrease in the activity of antioxidant enzymes (Cat and GSR) in the testes of life-long HFD fed mice. Therefore, it is possible that extra lipid intake, notably in PUFAs, is the cornerstone in testicular antioxidant balance. This hypothesis is supported by the differences in lipid fractions between groups (Figure 4), the differences in the correlations of lipid fractions against sperm parameters (Figure 6A), and the sample separation achieved by the corresponding PCA (Figure 6B)."

"...In sum, our data demonstrates that a HFD during early life akin to childhood and puberty causes an excessive accumulation of unsaturated FAs is testes. A diet intervention, replacing HFD for a balanced diet was proven effective in protecting/preventing metabolic dysfunction. However, a HFD during early life caused irreversible metabolic remodeling in testes, with long-term sperm defects. Dietary intervention in early adulthood promotes lipolysis in testes, particularly from unsaturated FAs, towards the CTRL state, but this process is apparently too slow to recover normal sperm parameters. Mechanistically, our data suggests that HFD promotes a pro-inflammatory state in testis, aggravated by a positive feedback system that favors the accumulation of n-6 PUFAs, precursors of inflammatory response signaling molecules. Our model did not allow us to verify whether testicular lipid composition and normal sperm quality could be achieved later in life..."

"...A new study explores whether a high-fat diet in childhood can irreversibly damage sperm quality later in life even after a healthy diet is adopted. The researchers studied young male mice; one group was given a high-fat diet after weaning, and another group was fed a high-fat diet for two months before switching to a standard diet. Both high-fat groups were compared with a control group on a standard diet. After four months on the diets, all mice were randomly placed in mating pairs with age-matched females. The research team observed reproductive success rate and the size of each litter. After an additional 10 weeks, researchers measured the males' blood sugar, insulin and reproductive hormone levels. They also analyzed sperm for factors that included overall concentration in the testes, fat levels, mitochondrial activity, viability, motility and morphology (shape). The research team found that...reducing fat in the diet helped to reverse elevated blood sugar levels. However, a high-fat diet negatively affected fat metabolism, caused an accumulation of fatty acids and reduced function of the antioxidant defense system in the testes that did not correct itself upon switching to a standard diet. These changes can lead to inflammation and metabolic changes that correspond with long-term sperm defects. The high-fat diet groups also had higher rates of pinhead sperm, a serious defect that alters the shape of sperm cells. The group that shifted from a high-fat to normal diet showed signs of lipolysis—the process of breaking down fats in the body—which is a positive change, but "this process is apparently too slow to recover normal sperm parameters," the researchers wrote."


Sep 12, 2015
Too many murine studies don't translate to humans for me to take them very seriously anymore.


Aug 28, 2016
How can we re saturated the testicles again? What comes to mind is direct application of stearic acid or indirecly saturating it with vitamin e + policosanol. Also t3 could be a saturator of pufa but Im not sure.


Oct 26, 2020
How about this

- PUFA = cheap
- cheap = good for Industrials who wanna profit from junk food
- junk food = high calories for cheap
- excess calories = health issues, even worse with a lack of nutrients

PUFAs are not a problem of calories are controlled and nutrition is good. Find any high quality study in humans instead of cherry-picking whatever suits a false narrative
Similar threads
Thread starter Title Forum Replies Date
haidut Dietary PUFA Causes (reversible) Male Infertility And Androgen Deficiency Scientific Studies 4
haidut PUFA Are Carcinogenic, Dietary Glycine Blocks Their Effect Scientific Studies 25
haidut Dietary Fat Intake Below 15% Depletes PUFA Scientific Studies 18
G Dietary changes from 1909-1974 Articles & Scientific Studies 2
bzmazu Mass Deception: Dietary Supplements Unproven, Experimental Vaccines Safe & Effective Rant or Rave 8
Frankdee20 Does dietary cholesterol intake increase it ? Cholesterol 8
Hgreen56 Salt, Sugar, And Dietary Fat Trigger Opioids In The Brain Which Can Contribute To Overeating Diet 4
Hgreen56 When Dietary Fat Intake Falls Below 10% Of Total Daily Calories, You’ll Still Gain Fat Diet 45
J How Much Dietary Fat Do You Actually Need For Hormones? Thyroid and Hormones 18
Frankdee20 Thoughts On Dietary Change For High Lipids Ask For Help or Advice 13
Frankdee20 Does Dietary Cholesterol Cause Heart Disease ? Cholesterol 5
GutFeeling Dietary Eggs Prevents And Alleviate Depression Scientific Studies 0
M Anti-Peat Dietary (organic) Iron Does Not Increase Tissue Iron Debate - Anti-Peat 40
berk Dietary Fat Cause Joint Pain Diet 14
nigma Dietary Caloric Efficiency Diet, Recipes 1
Mito Dietary Saturated Fat And Heart Disease: A Narrative Review Articles & Scientific Studies 1
Kingpinguin Dietary Vitamin E But Not Supplemental Significantly Decreased Risk Of Parkinson Scientific Studies 11
Mito Metabolic Effects Of A Prolonged, Very-high-dose Dietary Fructose Challenge In Healthy Subjects Scientific Studies 11
haidut Dietary Niacinamide (B3) Deficiency May Be A Cause Of Schizophrenia Scientific Studies 7
H Dietary Boron And Its Impact On Testicular Function, Thyroid, Calcium In Rams (2019) Minerals 17
Z Psoriasis Treatment, Dietary Advice Skin 10
Mito Dietary Salt Promotes Cognitive Impairment Through Tau Phosphorylation Articles & Scientific Studies 46
Mito Dietary Zinc Protects Against Streptococcus Pneumoniae Infection Zinc 0
Francisco Dietary Sources Of Vitamin E? Vitamins 51
R Dietary Carbohydrate Restriction Improves Metabolic Syndrome Independent Of Weight Loss Scientific Studies 2
Mito Impact Of Dietary Sucrose On Adiposity And Glucose Homeostasis Articles & Scientific Studies 1
jamies33 How Long Does It Take To See The Blood-calcium Lowering Effect Of High Dietary Calcium? Blood Work, Labs 6
P Prebiotic And Anti Endotoxin Effects Of Dietary Calcium Scientific Studies 0
Mito Dose-response Relation Between Dietary Sodium And Blood Pressure Articles & Scientific Studies 1
Broken man L-dehydroascorbic Acid Can Substitute L-ascorbic Acid As Dietary Vitamin C Source In Guinea Pigs Scientific Studies 2
L Can Having High Vitamin D Levels Compensate For Low Dietary Calcium Intake? Calcium 6
AlphaCog Dietary Fiber In Brewed Coffee Scientific Studies 0
Lokzo Role Of Dietary Histidine In The Prevention Of Obesity And Metabolic Syndrome Scientific Studies 6
jzeno Food Pattern Modeling Shows That The 2010 Dietary Guidelines For Sodium And Potassium Cannot Be Met Scientific Studies 13
Mito The Role Of Dietary Sugars In Health Articles & Scientific Studies 0
T Sarcosine Is Uniquely Modulated By Aging And Dietary Restriction In Rodents And Humans Scientific Studies 20
S Hedonistic Relationship To Food And Bad Dietary Recommendations By Governing Bodies Society 18
A Dietary Methionine Restriction Improves Thyroid Function Scientific Studies 1
Mito Dietary Cholesterol Contained In Whole Eggs Is Not Well Absorbed Articles & Scientific Studies 3
Mito Dietary Stearic Acid Regulates Mitochondria In Vivo In Humans Scientific Studies 40
raypeatclips Dietary Cocoa Reduces Metabolic Endotoxemia And Adipose Tissue Inflammation In High-Fat Fed Mice Scientific Studies 21
haidut Only Dietary Fat, Not Protein Or Sugar (sucrose), Drives Obesity Scientific Studies 25
haidut Dietary Nitrates Can Cause Mania After Just Two Weeks Of Consumption Scientific Studies 41
Amazoniac Virginia Livingston's Dietary Approach To Cancer Cancer, Degenerative Diseases 12
Mito Dietary Fat And Cardiometabolic Health: Evidence, Controversies, And Consensus For Guidance Articles & Scientific Studies 1
C Theory - Dietary Fat Induces Starvation Metabolism And Biological Failure? Discussing Dietary Models 31
Sativa Objective Dietary & Lifestyle Choices Diet, Recipes 1
W Vascular Effects Of Dietary Nitrate Via The Nitrate-nitrite-nitric Oxide Pathway Scientific Studies 11
R Dietary Liquid Advice/Tips Diet 0

Similar threads