Dietary Oil Composition And Endotoxin

Combie

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Sat fat = more endotoxin and transport
unsat fat = opposite
 

cliff

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Cox inhibitors like aspirin, fish oil etc. decrease endotoxin response. When you compare coconut oil to corn oil it completely abolishes the response to endotoxin(http://www.ncbi.nlm.nih.gov/pubmed/3545648).

"The prostaglandins are so problematic that their suppression is helpful, whether the inhibition is caused by aspirin or vitamin E, or by fish oil." -rp
 

Combie

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cliff said:
Cox inhibitors like aspirin, fish oil etc. decrease endotoxin response. When you compare coconut oil to corn oil it completely abolishes the response to endotoxin(http://www.ncbi.nlm.nih.gov/pubmed/3545648).

"The prostaglandins are so problematic that their suppression is helpful, whether the inhibition is caused by aspirin or vitamin E, or by fish oil." -rp

Thanks Cliff, i kinda got why fish oil might decrease, but was surprised to read that coconut oil INCREASED endotoxin.
 

KT-John

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cliff said:
Cox inhibitors like aspirin, fish oil etc. decrease endotoxin response. When you compare coconut oil to corn oil it completely abolishes the response to endotoxin(http://www.ncbi.nlm.nih.gov/pubmed/3545648).

"The prostaglandins are so problematic that their suppression is helpful, whether the inhibition is caused by aspirin or vitamin E, or by fish oil." -rp

Cliff

Do you remember what article that Peat quote is from?
 

gretchen

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Combie said:
cliff said:
Cox inhibitors like aspirin, fish oil etc. decrease endotoxin response. When you compare coconut oil to corn oil it completely abolishes the response to endotoxin(http://www.ncbi.nlm.nih.gov/pubmed/3545648).

"The prostaglandins are so problematic that their suppression is helpful, whether the inhibition is caused by aspirin or vitamin E, or by fish oil." -rp

Thanks Cliff, i kinda got why fish oil might decrease, but was surprised to read that coconut oil INCREASED endotoxin.

No, this can't be true.
 

Combie

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Adel moussa of suppversity posted the following in response to the study;

(Mani. 2013) -- According to a study from the University of Iowa, the endotoxemia response to a meal, i.e. the amount of inflammatory innately produced toxins from your gut that enter circulation in the postprandial phase, is increased in response to a meal that's high in saturated fat.

Figure 1: Endotoxin permeablity and changes in serum endotoxin levels in the hours subsequent to the ingestion of a test meal containing either 50ml coconut (CO), vegetable (VO) and fish oil (FO) in otherwise healthy pigs (Mani. 2013).
The scientists also found that omega-3 fatty acids from fish and cod liver oil reduced the amount of endotoxins hitting the blood stream and that olive, as well as vegetable oils exhibited a neutral effect. As the data in figure 1 (left) goes to show you, the underlying mechanism behind the saturated fat induced influx of toxins was a whopping +60% increase in the endotoxin permeability (Papp) of the guts of the 24 pigs on which the experiments have been conducted.


Click here to read more about a previous study that shed some light on the effects of certain nutrients on the gut microbiome.
Now you can certainly argue that the ground corn-soybean meal dough that was at the base of the test-meal was "the devil" here, but let's be honest, for the average Jane and Joe, there are similar "devils" in any standard meal, they consume, so that the finding that the addition of 50 ml fish oil (FO), vegetable oil (VO) or coconut oil (CO) made such a difference in terms of the influx of pro-inflammatory endotoxins is nothing you can simply ignore. The same goes for the fact these effects occurred in response to the ingestion of organic coconut oil (according to the researchers purchased from Spectrum Naturals Inc.), is actually somewhat unsettling and certainly not in line with some of the previously established benefits of coconut oil consumption, such as it's waist reducing effects in overweight subjects (click here to learn more).

What's also interesting is that previous rodent studies yielded different results. Laugerette et al., for example, found a similar increase as Mani et al. in mice, but in response to canola and sunflower oil (Laugerette. 2012). This raises the question in how far the effects may be mediated by the baseline diet and the corresponding bacterial composition of the small and large intestine (or species specific effects?). After all, the gram negative bacteria of which scientists believe that they increase in response to high fat diets have the highest endotoxin content. They populate the distal ileum and the colon and are supposedly the main sources for circulating endotoxin (Berg. 1999) - if you had less of them to begin with, you are not as likely to suffer from an acute influx of endotoxins in response to the ingestion of SFAs. Moreover, what it the endotoxins were released in response to the antimicrobial effects of coconut oil?
 

charlie

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So maybe more endotoxin in the beginning due to killing off the baddies?
 
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