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Dietary Nitrate Inhibits Iodide Uptake

Discussion in 'Scientific Studies' started by Kasper, Mar 20, 2016.

  1. Kasper

    Kasper Member

    Sep 11, 2013
    Perchlorate competitively blocks iodide from entering the thyroid. Those thyroid-related effects of environmental perchlorate have created great health concerns. However, nitrate, found in spinach, beets and other vegetables, seem to have similar or worse effects than perchlorate, as this study shows. This may also a reason to not eat carrots in too high quantities, as carrots also contain nitrates.

    Perchlorate versus other environmental sodium/iodide symporter inhibitors: potential thyroid-related health effects.
    Perchlorate is a known competitive inhibitor of the sodium/iodide symporter (NIS). Possible thyroid-related effects of environmental perchlorate have created great health concerns, especially in the US, resulting in a debated reference dose (RfD) of 0.0007 mg/kg per day in drinking water recommended by the National Academy of Sciences (NAS). However, the impact of other environmental NIS inhibitors and the role of iodine seem to have received little attention in the whole debate.

    The relative potencies of prevalent environmental NIS inhibitors (nitrate, thiocyanate and perchlorate) to inhibit iodine uptake have been estimated repeatedly with robust results. Our calculations show that nitrate and thiocyanate, acquired through drinking water or food, account for a much larger proportion of iodine uptake inhibition than perchlorate. Furthermore, the iodine uptake inhibitory effects of nitrate and thiocyanate - as defined by their legally accepted maximal contaminant levels in drinking water - exceed the potential effect of the proposed RfD for perchlorate by far.