1. **NEW** BL11 - Orange, Red & Infrared Therapy Body Light
    CLICK HERE!
    Dismiss Notice
  2. PL1 - Orange & Red Light Therapy Pod Light
    CLICK HERE!
    Dismiss Notice

Diamant - Liquid Adamantane For R&D

Discussion in 'IdeaLabs' started by haidut, Mar 15, 2017.

  1. mirc12354

    mirc12354 Member

    Joined:
    Jan 8, 2016
    Messages:
    234
    Does this product also potentiate the effects of nicotine?
     
  2. denise

    denise Member

    Joined:
    Oct 18, 2013
    Messages:
    246
    Gender:
    Female
    My guess would be yes, although in practice, I never noticed that it did. (I've used Diamant and then had a smoke within 30 minutes of taking it on a number of occasions, and don't recall consistently feeling an extra nicotine hit.)
     
  3. OP
    haidut

    haidut Member

    Joined:
    Mar 18, 2013
    Messages:
    11,727
    Gender:
    Male
    Location:
    USA / Europe
    Yeah, I think the SSRI's have different effects depending on the drug. Even though they are all lumped into the SSRI group this is probably misleading as some of them are way more serotonergic than others and some are even serotonin antagonists. I think the most successful ones (and the safest) are the strongest antagonists at 5-HT2C and the strongest inducers of allopregnanolon synthesis.
     
  4. OP
    haidut

    haidut Member

    Joined:
    Mar 18, 2013
    Messages:
    11,727
    Gender:
    Male
    Location:
    USA / Europe
    I would say only if it is administered together - i.e. somehow the nicotine was dissolved in it and rubbed on the skin or ingested.
     
  5. ecstatichamster

    ecstatichamster Member

    Joined:
    Nov 21, 2015
    Messages:
    3,282
    So here's my experience. I will narrate for my rat, who is in his little cage, and can't talk or write.

    If Rat could write he would say this:

    I started with maybe two or three drops orally per day and built up to maybe 10 or 12 drops.

    I like the way I feel with this. But the higher dosages cause me to crash in the afternoon. I think it was adrenaline being too low. My temperature would fall and I would feel really cold and have to put on a jacket, as if I had had too much reverse thyroid in my body.

    So I cut back the dose and that didn't happen today.

    I also think I get more headaches. Headaches are always a problem for me, but I still think that I feel overall better with this. I may stop taking it for a while. Not sure where it fits in, in the scheme of things.

    So ends my hypothetical Rat tail.
     
  6. OP
    haidut

    haidut Member

    Joined:
    Mar 18, 2013
    Messages:
    11,727
    Gender:
    Male
    Location:
    USA / Europe
    Thanks for the feedback. The feeling of cold is actually a sign body temps went up, not down. So, I would measure body temp when this happens. I think most rats feel best on around 10 drops split into 2 daily doses of 5 drops each. Have not seen reports yet that 10 drops did not work but 20 drops did. It seems powerful enough to have great effects even in low doses.
     
  7. ecstatichamster

    ecstatichamster Member

    Joined:
    Nov 21, 2015
    Messages:
    3,282
    Thank you. I took my temperature during the day and I was definitely cold.
     
  8. Joeyd

    Joeyd Member

    Joined:
    Jul 13, 2014
    Messages:
    931
    @haidut which Serotonin receptor does amantadine antagonise?
     
  9. OP
    haidut

    haidut Member

    Joined:
    Mar 18, 2013
    Messages:
    11,727
    Gender:
    Male
    Location:
    USA / Europe
    The studies on amantadine and rimantadine showed antagonism of 5-HT2 but the the pro-dopamine effects of the adamantanes leads to inhibition of TPH and thus reduced overall serotonin synthesis systemically. I think that is more important than specific receptor antagonism.
     
  10. Koveras

    Koveras Member

    Joined:
    Dec 17, 2015
    Messages:
    558
    Gender:
    Male
    @haidut

    Any thoughts on the pathogenesis of anti-NMDA receptor encephalitis and the benefits or risks of NMDA antagonism here?
     
  11. Wagner83

    Wagner83 Member

    Joined:
    Oct 15, 2016
    Messages:
    1,711
    Gender:
    Male
    Has anyone tried to combine diamant with the SFA ester version of e.g. pansterone or androsterone? If so what were the results and how does it compare to dmso in terms of potency?
     
  12. OP
    haidut

    haidut Member

    Joined:
    Mar 18, 2013
    Messages:
    11,727
    Gender:
    Male
    Location:
    USA / Europe
    I think this is a very rare condition and probably other factors than just NMDA are involved as well. Do you know of anybody who has had such encephalitis?
     
  13. Koveras

    Koveras Member

    Joined:
    Dec 17, 2015
    Messages:
    558
    Gender:
    Male
    "There has been a rapid increase in the characterization of encephalitis associated with antibodies to cell surface or synaptic proteins, starting with the report of 4 patients with prominent psychiatric symptoms who rapidly progressed into hypoventilation and coma. The disorder was subsequently identified as anti-NMDA receptor (NMDAR) encephalitis, now the best characterized and most frequently recognized autoimmune encephalitis, demonstrating that “newly identified” does not always mean “infrequent” or “rare.”"

    It seems to be a common feature of encephalitis now that they've been able to test for it / know what to look for. Possibly overlapping with multiple sclerosis, parkinsonism and other demyelinating diseases.

    I may have answered my own questions a bit with further research - ovarian teratomas seem to be the most common cause, although other malignancies seem to predispose as well. Some evidence of viral involvement and speculation around vaccines. I would guess like other autoimmune conditions excesses of estrogen and stress and deficiencies of protective steroids are involved, and there was one case study that noted a possible benefit of Coenzyme Q10 further hinting at the metabolic/mitochondrial side.

    Also found these comments:

    "Catatonia resistant to benzodiazepine and electroconvulsive therapy has been treated with NMDA-antagonists (amantadine and memantine). Theoretically, however, these may exacerbate anti-NMDA-receptor encephalitis"

    "Further evidence to suggest that antibodies are involved in the down regulation of NMDA receptors can be demonstrated by the use of NMDA-receptor antagonists such as ketamine and phencyclidine, which can cause symptoms similar to anti-NMDA-receptor encephalitis, including psychotic behaviour, signs of involvement of dopaminergic pathways (rigidity, dystonia, orofacial movements, tremor) and autonomic dysfunction.”
     
  14. Joeyd

    Joeyd Member

    Joined:
    Jul 13, 2014
    Messages:
    931
    Hold on is diamant a 5ht3 antagonist like memantine?
     
  15. Steene

    Steene Member

    Joined:
    Aug 29, 2017
    Messages:
    50
    Gender:
    Male
    So I skimmed through the whole thread but I am still unsure how to use the Gonadin + Adamantane combo.

    - orally 8 drops Gonadin + 8 drops Adamantane
    - topically 8 drops Gonadin + 8 drops Adamantane

    What would be best?
     
  16. OP
    haidut

    haidut Member

    Joined:
    Mar 18, 2013
    Messages:
    11,727
    Gender:
    Male
    Location:
    USA / Europe
    Possibly, but it has not been studies directly. All adamantane derivatives so far seem to increase dopamine synthesis and lower serum serotonin, through as of yet unidentified mechanism.
     
  17. OP
    haidut

    haidut Member

    Joined:
    Mar 18, 2013
    Messages:
    11,727
    Gender:
    Male
    Location:
    USA / Europe
    They seem to have different effects when used through different routes. I would start with topical.
     
  18. chimdp

    chimdp Member

    Joined:
    Jan 22, 2017
    Messages:
    34
    Gender:
    Male
    @haidut I understand taking this a few hours away from large doses of k2 because of the vit e, but I wasn't sure if this avoidance also apply Lapodin? I guess this question would also apply to MitoLipin and Lapodin?
     
  19. OP
    haidut

    haidut Member

    Joined:
    Mar 18, 2013
    Messages:
    11,727
    Gender:
    Male
    Location:
    USA / Europe
    Yes, I would avoid taking any of the quinone products at the same time as vitamin E containing ones. A few hours of waiting is usually enough to avoid issues.
     
Loading...