Diabetes Drug Induces MPB!!! Complete reversal after stopping treatment.

[GorillaHead]

Teneligliptin-induced hair loss: A case report

Diabetes mellitus (DM) refers to a group of common metabolic disorders that share the common phenotype of hyperglycemia secondary to various pathophysiologic mechanisms that include reduced insulin secretion, decreased glucose utilization, and increased ...

www.ncbi.nlm.nih.gov

If this study is to be trusted. Then we just made a huge leap in understanding male pattern baldness.

MPB is almost certainly related to insulin without a doubt as both genes related to insulin have been implicated. and conditions such as myotonic dytrophy highly correlated to mpb and also have insulin related pathology.


I will need to spend more time to understand if increasing dpp-4 is the simple solution to stopping the hairloss or if the drug does more than just inhibit dpp-4.


This is is exciting.

 

[GorillaHead]

Honestly surprised no one has shown interest in this by now

 

[GenericName86]

Well if inhibiting dpp-4 is involved in mpb then then things like berberine would be bad for hair? At least those with mpb? It's a dpp-4 inhibitor I believe.

 

[GorillaHead]

Well if inhibiting dpp-4 is involved in mpb then then things like berberine would be bad for hair? At least those with mpb? It's a dpp-4 inhibitor I believe.

Perhaps yes in men at least if we assume thats what happened.

 

[Yann]

Thanks for sharing!

 

[Quelsatron]

Could possibly just be random spot hairloss that happened to center on the vertex, there are many different kinds of alopecia which are much easier to cure than androgenic alopecia

 

[GorillaHead]

Could possibly just be random spot hairloss that happened to center on the vertex, there are many different kinds of alopecia which are much easier to cure than androgenic alopecia

True true.

 

[Tim Lundeen]

It would have been interesting to have 24-hour continuous glucose readings for this patient. The drug suppresses glucagon, but you need glucagon during the night to keep blood glucose in a normal range. It's possible that low glucose during the night stressed hair follicles, and that caused the hair loss. Not convinced that DPP4 is directly related to hair loss.

 

[GorillaHead]

It would have been interesting to have 24-hour continuous glucose readings for this patient. The drug suppresses glucagon, but you need glucagon during the night to keep blood glucose in a normal range. It's possible that low glucose during the night stressed hair follicles, and that caused the hair loss. Not convinced that DPP4 is directly related to hair loss.

Fair. But dpp-4 and dpp-8 receptors found in the skin. Remember that

 

[Tim Lundeen]

Fair. But dpp-4 and dpp-8 receptors found in the skin. Remember that

Excellent point

 

[GorillaHead]

Excellent point

There is also the fact patient in the study could be suffering from central cicatricial alopecia which i have seen manifests just like mpb in which case a study showed topical metdormin regrew hair.

 

[Tim Lundeen]

There is also the fact patient in the study could be suffering from central cicatricial alopecia which i have seen manifests just like mpb in which case a study showed topical metdormin regrew hair.

Metformin reduces ROS from mitochondria complex I (Metformin-Induced Mitochondrial Complex I Inhibition: Facts, Uncertainties, and Consequences - PubMed), so would not be surprising if it helped alopecia (by reducing ROS). Unlikely that this is the optimal solution, seems like it would be better to keep complex I working.