DHT Increases Aromatase Activity In Skin

Adrenaline

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Interesting study. DHT stimulates aromatase activity in human skin. Now, what's that supposed to mean?

Stimulation of aromatase activity by dihydrotestosterone in human skin fibroblasts. - PubMed - NCBI

Aromatase activity was stimulated 3- to 20-fold by DHT at concentrations 10(-10) and 10(-9) M. It was necessary to preincubate the cells with DHT for 48 h in order to bring about this stimulation.

This stimulatory effect was prevented by incubation of the cells with cycloheximide or actinomycin D, suggesting that DHT acts to increase aromatase activity in cultured fibroblasts by inducing the synthesis of new proteinaceous material.
 

tankasnowgod

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Interesting study. DHT stimulates aromatase activity in human skin. Now, what's that supposed to mean?

Not a whole lot. This was an in vitro study that had to incubate these cells with DHT for 48 hours to see this effect, even 24 hours wasn't significant. And it was gential skin where this came from, so it may have even more sensitivity to reproductive hormones.

I doubt this would apply to the ways people normally take DHT or other hormones, like pills or injections. Even topical application likely wouldn't be an issue, since it usually absorbs into the skin within minutes, and doesn't stay on over a few days period.

But to be on the safe side, just don't bathe in a DHT solution for 48 hours. Limit yourself to 20 hours or less, and you should be fine.
 
OP
Adrenaline

Adrenaline

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Joined
Sep 9, 2019
Messages
96
Not a whole lot. This was an in vitro study that had to incubate these cells with DHT for 48 hours to see this effect, even 24 hours wasn't significant. And it was gential skin where this came from, so it may have even more sensitivity to reproductive hormones.

I doubt this would apply to the ways people normally take DHT or other hormones, like pills or injections. Even topical application likely wouldn't be an issue, since it usually absorbs into the skin within minutes, and doesn't stay on over a few days period.

But to be on the safe side, just don't bathe in a DHT solution for 48 hours. Limit yourself to 20 hours or less, and you should be fine.

Thank you for explanation.
 

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