DHT Gel Shuts Down LH, FSH, Estradiol And T But Sustained Sexual Function

[redlight]

Sartorius GA, Ly LP, Handelsman DJ.

Male Sexual Function Can Be Maintained Without Aromatization: Randomized Placebo-Controlled Trial of Dihydrotestosterone (DHT) in Healthy, Older Men for 24 Months. The Journal of Sexual Medicine.

http://onlinelibrary.wiley.com/doi/1...12550/abstract

Introduction Male sexual function is highly androgen dependent but whether aromatization of testosterone (T) to estradiol is required remains contentious.

Aim This study aims to investigate the effects of selective estrogen deficiency induced by a nonaromatizable androgen, dihydrotestosterone (DHT), on sexual function of healthy middle-aged and older men.

Methods Randomized clinical trial of daily transdermal DHT (70 mg) or placebo gel treatment in 114 healthy middle-aged and older (>50 years, mean 60.5 years) men without known prostate disease maintaining selective estrogen deficiency for 24 months.

Outcome Measures and Analysis The end points were responses to a psychosexual and mood questionnaire completed before, at 3 months, then at 6 monthly intervals during and 3 months after study. Data were analyzed by mixed model analysis of variance for repeated measures using age and body mass index (BMI) as covariates and including interactions of treatment with age and time-on-study.

Results DHT treatment increased serum DHT with complete suppression of serum T, luteinizing hormone, follicle stimulating hormone, and estradiol throughout the 24-month study resulting in reduced spinal bone density.

There were no spontaneous complaints, or discontinuations for, adverse effects on sexual function during the study.

DHT administration had no effects on any of 33 measures of sexual function and mood, apart from a mild, but significant decrease in overall sexual desire, which was reversible after cessation of treatment. Increasing age and less often increasing BMI were associated with significant decreases in most aspects of sexual function.

Conclusions We conclude that aromatization plays only a minimal role in maintenance of sexual function in healthy eugonadal middle-aged or older men, but age and obesity are significantly associated with decreases in most aspects of self-reported sexual function and satisfaction.

The dependence of male sexual function on aromatization may be conditional on age and obesity and can be overcome by a nonaromatizable androgen.

DHT Gel Shuts Down LH, FSH, Estradiol and T But Sustained Sexual Function

 

[ecstatichamster]

there are studies where they castrate rats, suppress their T, and just on estrogen alone they maintain sexual abilities and interest more or less.

Lots we don't know.

 

[Dante]

there are studies where they castrate rats, suppress their T, and just on estrogen alone they maintain sexual abilities and interest more or less.

Lots we don't know.

Read a book that endocrinology varies by species. T and E2 were both required for rats (DHT alone was not enough) whereas in some primates DHT alone was enough(now humans added) for sexual function. Extrapolating rats neuro-endocrinology responses to higher primates/humans is very short sighted

 

[Wagner83]

Results: DHT treatment increased serum DHT with complete suppression of serum T, luteinizing hormone, follicle stimulating hormone, and estradiol throughout the 24-month study resulting in reduced spinal bone density.
DHT administration had no effects on any of 33 measures of sexual function and mood, apart from a mild, but significant decrease in overall sexual desire, which was reversible after cessation of treatment.

By the way where do I enroll for these trials?