DHEA Suppresses Longitudinal Bone Growth?

[TheHound]

I remember reading the Ray Peat said he grew after taking DHEA.

This study:

http://press.endocrine.org/doi/full/10.1210/en.2010-0920

apparently found that DHEA suppressed bone growth. They even used an aromatase inhibitor to make sure it wasn't excess estrogen causing the bone growth suppression. I didn't read the full study but does anyone know what to make of it?

 

[TheHound]

bump

 

[DaveFoster]

First thing that comes to mind is the lack of control for DHT synthesis from DHEA.

The second thing is the potential for DHEA to halt bone growth at higher doses; the researchers offer that "suppression is mediated through the ER, especially ERβ, via the NF-κB signaling pathway."

 

[Dante]

Quoting from the paper - although there are reports suggesting that DHEA could act on ERs without conversion to estrogens.
The thing is that even DHT metabolites could bind to ER -beta receptors with more affinity than estradiol itself. Whether the DHEA, 3-beta diol or estradiol binding to the ER-beta invoke the same genomic and non -genomic responses that's the question. I doubt that's the case