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"Dehydroepiandrosterone inhibits the activation and dysfunction of endothelial cells induced by high glucose concentration"
Steroids,Volume 77, Issue 3, February 2012, Pages 233-240
ElizabethHuerta-GarcíaaJosé LuisVentura-GallegosbcMa. Elena CrescencioVictorianoaAngélicaMontiél-DávalosadGerardoTinoco-JaramilloeRebecaLópez-Marure
-Dehydroepiandrosterone inhibits the activation and dysfunction of endothelial cells induced by high glucose concentration - ScienceDirect
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Abstract
Dehydroepiandrosterone (DHEA), an adrenal steroid, has a protective role against diabetes; however, its mechanisms of action are unknown. Here, we focus on the effect of DHEA on the activation of endothelial cells induced by a high concentration of glucose.
High concentrations of glucose (>20 mM) induced an increase in adhesion, an increment in mainly E-selectin and PECAM-1 expression, as well as in ROS and NO production, eNOS expression, translocation of NF-κB, and degradation of its inhibitor IκB-α. DHEA abolished adhesion and the increase of E-selectin, ICAM-1, VCAM-1, and PECAM-1 induced by glucose. In addition, DHEA completely blocked oxidative stress and decreased translocation of NF-κB and the degradation of IκB-α induced by glucose. These results suggest that DHEA protects against the activation of endothelial cells induced by high concentrations of glucose, indicating that DHEA could be useful in the treatment of hyperglycemia and diabetes.
Steroids,Volume 77, Issue 3, February 2012, Pages 233-240
ElizabethHuerta-GarcíaaJosé LuisVentura-GallegosbcMa. Elena CrescencioVictorianoaAngélicaMontiél-DávalosadGerardoTinoco-JaramilloeRebecaLópez-Marure
-Dehydroepiandrosterone inhibits the activation and dysfunction of endothelial cells induced by high glucose concentration - ScienceDirect
--
Abstract
Dehydroepiandrosterone (DHEA), an adrenal steroid, has a protective role against diabetes; however, its mechanisms of action are unknown. Here, we focus on the effect of DHEA on the activation of endothelial cells induced by a high concentration of glucose.
High concentrations of glucose (>20 mM) induced an increase in adhesion, an increment in mainly E-selectin and PECAM-1 expression, as well as in ROS and NO production, eNOS expression, translocation of NF-κB, and degradation of its inhibitor IκB-α. DHEA abolished adhesion and the increase of E-selectin, ICAM-1, VCAM-1, and PECAM-1 induced by glucose. In addition, DHEA completely blocked oxidative stress and decreased translocation of NF-κB and the degradation of IκB-α induced by glucose. These results suggest that DHEA protects against the activation of endothelial cells induced by high concentrations of glucose, indicating that DHEA could be useful in the treatment of hyperglycemia and diabetes.
