DHEA And Muscle Growth

Orius

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Joined
Dec 8, 2017
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117
I'm currently on 10mg of prednisone and reducing slowly, due to an auto-immune condition. One thing prednisone does in my case is cause weight loss, so I am chronically underweight until I get off this stuff.

I've been taking DHEA and pregnenolone to support my hormone system, as prednisone tends to take these hormone pathways offline. I also support them with conversion minerals, like selenium, boron, etc.

In the past, I've noticed that a combo of DHEA, pregnenlone and boron has helped me to develop muscle tone as I regain body mass and musculature following auto-immune flares, but I'm not 100% sure of this correlation.

That's what I'm coming here to ask.

Can DHEA help men develop passive muscle growth? I'm not talking about having body-building type muscle or anything, just normal muscle tone. I know one thing it does is reduce the muscle to fat ratio, but I don't know if it increases muscle mass. One reason I ask is because I know that weightlifting, a muscle building exercise, causes DHEA release... so I'm wondering if there's a connection.

Thank you!
 

Hans

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Joined
Aug 24, 2017
Messages
2,874
I'm currently on 10mg of prednisone and reducing slowly, due to an auto-immune condition. One thing prednisone does in my case is cause weight loss, so I am chronically underweight until I get off this stuff.

I've been taking DHEA and pregnenolone to support my hormone system, as prednisone tends to take these hormone pathways offline. I also support them with conversion minerals, like selenium, boron, etc.

In the past, I've noticed that a combo of DHEA, pregnenlone and boron has helped me to develop muscle tone as I regain body mass and musculature following auto-immune flares, but I'm not 100% sure of this correlation.

That's what I'm coming here to ask.

Can DHEA help men develop passive muscle growth? I'm not talking about having body-building type muscle or anything, just normal muscle tone. I know one thing it does is reduce the muscle to fat ratio, but I don't know if it increases muscle mass. One reason I ask is because I know that weightlifting, a muscle building exercise, causes DHEA release... so I'm wondering if there's a connection.

Thank you!
Yes it can increase muscle mass if you have low amounts of muscle mass to start with. But once you reach a certain level, it has minor if not zilch effect on muscle growth. Meaning, it is needed, but giving the body more will not promote hypertrophy past a certain point.
 

Orius

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Joined
Dec 8, 2017
Messages
117
Yes it can increase muscle mass if you have low amounts of muscle mass to start with. But once you reach a certain level, it has minor if not zilch effect on muscle growth. Meaning, it is needed, but giving the body more will not promote hypertrophy past a certain point.

So in other words it can be good for recovery if you atrophied due to illness (I am under weight), but not for actual bodybuilding hypertrophy.
 

Ponce

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Joined
Mar 23, 2019
Messages
16
If you take DHEA it will be reduce intrinsic prednisone’s effects due to a decreased of the enzyme 11β-HSD1 which converts cortisone into cortisol (immunosuppressive), and this by increasing the expression of 11β-HSD2. DHEA works this way.
So if you supplement DHEA you can give up your glucocorticoids.
DHEA itself is a substance involved in the regulation of the immune system, among others...
 

Ponce

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Mar 23, 2019
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With DHEA you can take some aspirin and cyproheptadine to reduce aromatase, and then increase DHEA’ effects.
 
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