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You should notice the effects of the T3 quickly (half life is a few hours). The T4 builds up slowly and can take up to 4 weeks I think to reach a stable level, so you may well continue to notice changes over that time. The cautious approach is to only increase T4 by a little then, if more is needed.miko said:Ok, so I'm on thyroid (T3 and T4) - going slowly, not feeling much besides a little warmer hands, and legs, and I like it very much :)