Decrease In Anxiety By Inhibiting Glyoxalase I (Additional Reason For Pau D'arco)

Discussion in 'Scientific Studies' started by Lejeboca, Jan 21, 2019.

  1. Lejeboca

    Lejeboca Member

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    Mostly the role of glyoxalase I (GloI) inhibition in cancer therapy has been discussed on RP. The paper below shows its role for decreasing anxiety.

    Earlier posts (see, e.g., Cottage Cheese & Fresh Flax Seed Oil Cures Cancer and Is Pau D'Arco Really The Best Option Out Of The Tabebuia Buffet?) and the entire thread on lapachone state that pau d'arco (Tabebuia spp.) is the best natural GloI inhibitor. Along come chinese skullcap (scutellaria baicalensis) and curcumin (Curcuma longa) .

    Glyoxalase 1 increases anxiety by reducing GABAA receptor agonist methylglyoxal

    Abstract: Glyoxalase 1 (Glo1) expression has previously been associated with anxiety in mice; however, its role in anxiety is controversial, and the underlying mechanism is unknown. Here, we demonstrate that GLO1 increases anxiety by reducing levels of methylglyoxal (MG), a GABAA receptor agonist. Mice overexpressing Glo1 on a Tg bacterial artificial chromosome displayed increased anxiety-like behavior and reduced brain MG concentrations. Treatment with low doses of MG reduced anxiety-like behavior, while higher doses caused locomotor depression, ataxia, and hypothermia, which are characteristic effects of GABAA receptor activation. Consistent with these data, we found that physiological concentrations of MG selectively activated GABAA receptors in primary neurons. These data indicate that GLO1 increases anxiety by reducing levels of MG, thereby decreasing GABAA receptor activation. More broadly, our findings potentially link metabolic state, neuronal inhibitory tone, and behavior. Finally, we demonstrated that pharmacological inhibition of GLO1 reduced anxiety, suggesting that GLO1 is a possible target for the treatment of anxiety disorders.
     
  2. bdawg

    bdawg Member

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    Good find! any more research related to the Glo1 pathway of anxiety reduction?
     
  3. olive

    olive Member

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    Pair Pau D’Arco with L-Threonine.

    L-Threonine creates methylglyoxal, a polyamine inhibitor.
    Lapachone, found in Pau D’Arco, is a glyoxalase l inhibitor which stops methylglyoxal created by l-threonine being destroyed and turned into lactic acid.
     
  4. bdawg

    bdawg Member

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    I did some quick research.

    Lapachol seems to have some toxic/anti-fertility anti embryo effects

    Is it a case of look at the net positive? otherwise this herb seems very promising
     
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