Ray Peat Interview Dec 2020 - Danny Roddy, Ray Peat, Georgi Dinkov - Body Temperature, Current Events, Etc.

lampofred

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Tonight at 6:30 PST. On a Thursday this time...

 

mrchibbs

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Seems like it will be a good one! Great so far.
 

Doc Sandoz

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Ray says in this interview he always keeps a tank of C02 around, and that he in fact had one sitting by him as he spoke. Does anyone know how he uses it? I know he's filled up large plastic bags and taken C02 baths but, if he keeps a tank by his desk or easy chair, I'd imagine he also uses it in less involved ways. He said once he prevented his smashed hand from swelling up by enclosing it in a plastic bag and filling the bag with C02, but since he keeps his tank so conveniently located, I can't help but wonder if he simply inhales it too. Pure C02 can kill as it has from eruptions from Lake Nyos in Africa, yet death there is from suffocation as the C02 displaces all the O2. It doesn't seem like an occasional hit, maybe not direct from the tank but rather by decanting some into a paper bag and taking a couple breaths, would be all that dangerous. Very curious as to whether Ray does this.
 
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Starship

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I still think that calorie restriction is the safest bet for extending lifespan because there is evidence for it. University of Wisconsin study kind of shows that monkeys lived longer. My unscientific gut intuition tells me that calorie restriction is the way to go until there is more evidence that opposite is true.
I personally would rather feel slightly worse but live longer.
 
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I still think that calorie restriction is the safest bet for extending lifespan because there is evidence for it. University of Wisconsin study kind of shows that monkeys lived longer. My unscientific gut intuition tells me that calorie restriction is the way to go until there is more evidence that opposite is true.
I personally would rather feel slightly worse but live longer.

methionine depletion achieves the same without calorie reduction.
 

tankasnowgod

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I still think that calorie restriction is the safest bet for extending lifespan because there is evidence for it. University of Wisconsin study kind of shows that monkeys lived longer. My unscientific gut intuition tells me that calorie restriction is the way to go until there is more evidence that opposite is true.
I personally would rather feel slightly worse but live longer.
Well, Roy Walford was all about CR in humans, even wrote the book "The 120 Year Diet," and he died at 79-


That should give anyone pause. If one of the biggest proponents of caloric restriction can't make it work........ why would you think any average human could?

Yeah, those Monkey studies might be evidence for CR.......... but they are also evidence for protein restriction, methionine restriction, tryptophan restriction, iron restriction, toxin restriction, PUFA restriction, and on and on. If you are restricting calories, by definition, you are restricting all those things..... and more.

But who wants to starve and live forever? Sounds freaking miserable.

Also, CR studies have only been done on captive animals. It's never been replicated in the wild. Prolly cause any starving animal would get killed as prey pretty quickly, or you know....., maybe eat something.

I think the best bet is doing things like donating blood, lowering PUFA, restricting methionine and/or adding a lot of glycine, and so on. Or betting on the bioenergetic theory, like many of us here are. More evidence that those techniques would work, and if they don't...... hey, at least you didn't starve yourself for 30+ years or so.

More on Walford-


"They would receive nothing from outside, not even air or water, which would be recycled by the indoor ecosystem. When the crew entered the Biosphere on September 26, 1991, Walford cut a striking figure in his Star Trek–style uniform, which perfectly matched his Spock-like ears and shiny dome. Things soon took an unexpected turn, however, when the explorers discovered that they could not produce enough food to feed themselves.

Spotting an opportunity to turn lemons into diet lemonade, Walford decided that this was the perfect chance to study caloric restriction in people: Henceforth, the eight crew members would be placed on a sharply reduced ration of less than eighteen hundred calories per person per day, at first. As team physician, Walford would monitor its effects on them."

........


"Not surprisingly, the Terranauts lost weight like sumo wrestlers in a steam room, shedding pounds until their average BMI dropped below twenty for men and women alike (or in scientific terms, “really skinny”). One man lost 58 pounds, going from a portly 208 to a sleek 150.

They lost weight so fast that Walford grew concerned that their fat cells were releasing toxins, like pesticides and pollutants, back into their bodies. They were indeed, he found, but the strict diet and heavy physical workload also caused more immediate problems, like that they were starving."

..........

"For Walford, though, the end of the Biosphere marked the beginning of a dark new chapter of his life. He had been fit and vibrant when he entered the capsule, looking far younger than his sixty-seven years. Two years inside had ravaged his body. Perhaps it was the lack of food, perhaps something else, but in photos taken in the Biosphere, Walford is thin to the point of emaciation, his eyes haggard and sunken.

He’d lost 25 pounds from an already-lean 145, and he looks much older than the post- Biosphere version of himself, on the right.

But the real damage was invisible. In the six months after leaving the Biosphere, Walford fell into a deep depression, drinking his way through a bottle of vodka every four days. He had injured his back while working in the compound, and he could barely walk, at first.

Something seemed to have changed in his brain, as well: Just three years after leaving the Biosphere, he began experiencing episodes of “freezing,” where he would simply stop walking, and fall down. Soon he required a walker."

If you really want to attempt CR, proceed with extreme caution.
 
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Starship

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methionine depletion achieves the same without calorie reduction.
Well, Roy Walford was all about CR in humans, even wrote the book "The 120 Year Diet," and he died at 79-


That should give anyone pause. If one of the biggest proponents of caloric restriction can't make it work........ why would you think any average human could?

Yeah, those Monkey studies might be evidence for CR.......... but they are also evidence for protein restriction, methionine restriction, tryptophan restriction, iron restriction, toxin restriction, PUFA restriction, and on and on. If you are restricting calories, by definition, you are restricting all those things..... and more.

But who wants to starve and live forever? Sounds freaking miserable.

Also, CR studies have only been done on captive animals. It's never been replicated in the wild. Prolly cause any starving animal would get killed as prey pretty quickly, or you know....., maybe eat something.

I think the best bet is doing things like donating blood, lowering PUFA, restricting methionine and/or adding a lot of glycine, and so on. Or betting on the bioenergetic theory, like many of us here are. More evidence that those techniques would work, and if they don't...... hey, at least you didn't starve yourself for 30+ years or so.
Thanks for your input guys. I believe in longevity escape velocity, so to me it's worth torturing myself with CR with short eating window just in case that would turn out to be important. I can just stop doing CR whenever there will be no danger from dying of an old age or science will be 100% sure that it isn't necessary. We need to hit longevity escape velocity guys, life in the next few centuries is going to be awesome, especially on Mars.
 

meatbag

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I still think that calorie restriction is the safest bet for extending lifespan because there is evidence for it. University of Wisconsin study kind of shows that monkeys lived longer. My unscientific gut intuition tells me that calorie restriction is the way to go until there is more evidence that opposite is true.
I personally would rather feel slightly worse but live longer.
I used to think the same, you might find these posts interesting;

Low-protein High-carb Diet Has The Same Benefits As Caloric Restriction: Low-protein High-carb Diet Has The Same Benefits As Caloric Restriction


A High-carb Diet May Explain Why Okinawans Live So Long : A High-carb Diet May Explain Why Okinawans Live So Long

Optimal Diet For Increasing Lifespan: Optimal Diet For Increasing Lifespan

Blocking Serotonin Extends Lifespan By 40%, Triples Youthspan: Blocking Serotonin Extends Lifespan By 40%, Triples Youthspan

Serotonin Antagonists Extend Lifespan, SSRI Dramatically Shorten It : Serotonin Antagonists Extend Lifespan, SSRI Dramatically Shorten It

The Benefits Of Fasting Are Due To Lowering Endotoxin (LPS), Not Less Calories : The Benefits Of Fasting Are Due To Lowering Endotoxin (LPS), Not Less Calories


 

tankasnowgod

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Thanks for your input guys. I believe in longevity escape velocity, so to me it's worth torturing myself with CR with short eating window just in case that would turn out to be important. I can just stop doing CR whenever there will be no danger from dying of an old age or science will be 100% sure that it isn't necessary. We need to hit longevity escape velocity guys, life in the next few centuries is going to be awesome, especially on Mars.

Again, there is only very limited evidence that CR works in captive animals (like Monkeys), and zero evidence it works in humans, captive or free living.

But if you want to live to 79 like Walford, fall into a deep depression, have "freezing" episodes, by all means, go for it.

Why do you think the next few centuries will be "awesome?" This year sucked royally. I have zero desire to increase the time I spend on this prison planet in this lifetime, especially if starvation is the ticket. And starvation that would last for several decades, to boot.

I see no evidence that life on Mars would be awesome, either. They just have a bunch of red dirt. At least in the Vegas desert, they have awesome casinos.
 

Starship

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Again, there is only very limited evidence that CR works in captive animals (like Monkeys), and zero evidence it works in humans, captive or free living.

But if you want to live to 79 like Walford, fall into a deep depression, have "freezing" episodes, by all means, go for it.

Why do you think the next few centuries will be "awesome?" This year sucked royally. I have zero desire to increase the time I spend on this prison planet in this lifetime, especially if starvation is the ticket. And starvation that would last for several decades, to boot.

I see no evidence that life on Mars would be awesome, either. They just have a bunch of red dirt. At least in the Vegas desert, they have awesome casinos.
I think that next few centuries are going to awesome because of all technological progress humanity is going to make. Flying to other solar systems, having all kinds of cool gadgets and stuff like that. Maybe it will get boring quickly, I don't know. I just like living.
 

tankasnowgod

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I think that next few centuries are going to awesome because of all technological progress humanity is going to make. Flying to other solar systems, having all kinds of cool gadgets and stuff like that. Maybe it will get boring quickly, I don't know. I just like living.

Why do you think we're gonna fly to other solar systems? We haven't even been to the moon-


As Haidut said in that thread, the greatest technological invention in 2015 was a cool new way to browse Twitter.

This year, people are beyond terrified of a fairy tale virus. Seriously, there is more evidence Bigfoot exists than SARS-Cov-2. Ain't no way we're getting off this rock as long as we're ruled by Satanists like the Rockefellers.

The future's gonna suuuuuuuuuuuck. We're Arthur Dent and Ford Prefect at the end of Restaurant at the End of The Universe. Best to abscond to a cave with some of those primitive girls, and wait for a random couch to show up 10-12 years later.
 
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mrchibbs

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I think that next few centuries are going to awesome because of all technological progress humanity is going to make. Flying to other solar systems, having all kinds of cool gadgets and stuff like that. Maybe it will get boring quickly, I don't know. I just like living.

Is it not possible you're romanticizing what the future will look like, instead of appreciating what we have now? If you like living don't sacrifice your enjoyment of it now.

Commercial (i.e. accessible) space travel (to our own solar system) probably won't be a reality until 2100.

By the time we have the capacity to travel to other solar systems, it will likely be at least 2200 or 2300, calorie restriction won't get you there.
 

Mito

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My unscientific gut intuition tells me that calorie restriction is the way to go until there is more evidence that opposite is true.

Uncoupled and surviving: individual mice with high metabolism have greater mitochondrial uncoupling and live longer​


Abstract
Two theories of how energy metabolism should be associated with longevity, both mediated via free-radical production, make completely contrary predictions. The 'rate of living-free-radical theory' (Pearl, 1928; Harman, 1956; Sohal, 2002) suggests a negative association, the 'uncoupling to survive' hypothesis (Brand, 2000) suggests the correlation should be positive. Existing empirical data on this issue is contradictory and extremely confused (Rubner, 1908; Yan & Sohal, 2000; Ragland & Sohal, 1975; Daan et al., 1996; Wolf & Schmid-Hempel, 1989]. We sought associations between longevity and individual variations in energy metabolism in a cohort of outbred mice. We found a positive association between metabolic intensity (kJ daily food assimilation expressed as g/body mass) and lifespan, but no relationships of lifespan to body mass, fat mass or lean body mass. Mice in the upper quartile of metabolic intensities had greater resting oxygen consumption by 17% and lived 36% longer than mice in the lowest intensity quartile. Mitochondria isolated from the skeletal muscle of mice in the upper quartile had higher proton conductance than mitochondria from mice from the lowest quartile. The higher conductance was caused by higher levels of endogenous activators of proton leak through the adenine nucleotide translocase and uncoupling protein-3. Individuals with high metabolism were therefore more uncoupled, had greater resting and total daily energy expenditures and survived longest - supporting the 'uncoupling to survive' hypothesis.
 

schultz

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Fred

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In the interview at 01:07:053 , Ray says "I just saw a recent publication validating the fact that we do have the reverse transcriptase enzymes that can turn viral RNA into DNA which can then be integrated into our genome" I found this study entitled, " SARS-CoV-2 RNA reverse-transcribed and integrated into the human genome" . In the abstract, they say this, " To experimentally corroborate the possibility of viral retro-integration, we describe evidence that SARS-CoV-2 RNAs can be reverse transcribed in human cells by reverse transcriptase (RT) from LINE-1 elements or by HIV-1 RT, and that these DNA sequences can be integrated into the cell genome and subsequently be transcribed." This is pure uninformed speculation, but I wonder if the HIV positive results in Australian vaccine trials were due to the intentional use of HIV RT as a means of delivering new "code" into the body. Also, the abstract points out "the possibility that SARS-CoV-2 RNAs can be reverse-transcribed and integrated into the human genome and that transcription of the integrated sequences might account for PCR-positive tests." (!!!!) Huge implications there!!!!
 
J

jb116

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In the interview at 01:07:053 , Ray says "I just saw a recent publication validating the fact that we do have the reverse transcriptase enzymes that can turn viral RNA into DNA which can then be integrated into our genome" I found this study entitled, " SARS-CoV-2 RNA reverse-transcribed and integrated into the human genome" . In the abstract, they say this, " To experimentally corroborate the possibility of viral retro-integration, we describe evidence that SARS-CoV-2 RNAs can be reverse transcribed in human cells by reverse transcriptase (RT) from LINE-1 elements or by HIV-1 RT, and that these DNA sequences can be integrated into the cell genome and subsequently be transcribed." This is pure uninformed speculation, but I wonder if the HIV positive results in Australian vaccine trials were due to the intentional use of HIV RT as a means of delivering new "code" into the body. Also, the abstract points out "the possibility that SARS-CoV-2 RNAs can be reverse-transcribed and integrated into the human genome and that transcription of the integrated sequences might account for PCR-positive tests." (!!!!) Huge implications there!!!!
But the "positivity" is normal as all respiratory virus after "infection" can be detected, and even long after the fact. It's the interpretation of this all that makes it seem like there is warranted investigation to understand the "PCR positive test." I think this is a mistake because again it fuels the narrative of some special, novel extremely problematic virus. What we are detecting would have held true 20 years ago; 30 years ago; like 3 weeks ago, etc. It's business as usual with the [intentional] obfuscation of PCR thrown in for good measure. Of which the father of the test implored should not be used for diagnosis or implying infection. Now if you want to use that implication in the direction of understanding PCR, that's a different story.
 

Fred

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But the "positivity" is normal as all respiratory virus after "infection" can be detected, and even long after the fact. It's the interpretation of this all that makes it seem like there is warranted investigation to understand the "PCR positive test." I think this is a mistake because again it fuels the narrative of some special, novel extremely problematic virus. What we are detecting would have held true 20 years ago; 30 years ago; like 3 weeks ago, etc. It's business as usual with the [intentional] obfuscation of PCR thrown in for good measure. Of which the father of the test implored should not be used for diagnosis or implying infection. Now if you want to use that implication in the direction of understanding PCR, that's a different story.
Yes, I know the test is being intentionally misused. The study just shows another means of testing "positive" while not actually having an infection. And if the hypothesis is accurate, the "positive" could be permanent.
 
J

jb116

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Yes, I know the test is being intentionally misused. The study just shows another means of testing "positive" while not actually having an infection. And if the hypothesis is accurate, the "positive" could be permanent.
Only issue is the dynamics of such results. A person can be negative one week, and positive the following. My sig. other who works in a test lab sees this day in and day out.
 

Jman

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Ray says in this interview he always keeps a tank of C02 around, and that he in fact had one sitting by him as he spoke. Does anyone know how he uses it? I know he's filled up large plastic bags and taken C02 baths but, if he keeps a tank by his desk or easy chair, I'd imagine he also uses it in less involved ways. He said once he prevented his smashed hand from swelling up by enclosing it in a plastic bag and filling the bag with C02, but since he keeps his tank so conveniently located, I can't help but wonder if he simply inhales it too. Pure C02 can kill as it has from eruptions from Lake Nyos in Africa, yet death there is from suffocation as the C02 displaces all the O2. It doesn't seem like an occasional hit, maybe not direct from the tank but rather by decanting some into a paper bag and taking a couple breaths, would be all that dangerous. Very curious as to whether Ray does this.
I emailed him, he said "In a big plastic bag, not breathing it"
 
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