David Sinclair On Extending Lifespan

[Tarmander]

I did a show on this guy's book. The first half is actually decent and has some solid ideas that are worth exploring. Especially the NAD boosting

The second half is elitism drivel

Anyone ever done a NAD IV? I tried one and maaan they are painful

 

[BestSinceDAYONE]

Wait, did you guys miss this post? Low dose aspirin resulted in the highest caloric intake AND the highest longevity. Metformin resulted in lower caloric intake and decent longevity. The longest living and largest crickets ate the most. Both aspirin and metformin were better than doing nothing.

Crickets Fed Low Dose Aspirin Live 143% Longer, Have Longer Childhoods And Higher Metabolic Rates

"Unlike the reigning dietary restriction paradigm, low aspirin conformed to a paradigm of “eat more, live longer.”"

All the crickets reading this will find that useful

 

[Sefton10]

Good thread debunking Sinclair


View: https://twitter.com/charlesmbrenner/status/1492902239312039938?s=21

 

[Whichway?]

Good thread debunking Sinclair


View: https://twitter.com/charlesmbrenner/status/1492902239312039938?s=21

Agree. Sinclair seems more a marketer and a huckster, than a real follow the evidence scientist. This Dr from New Zealand is also interested in healthy aging and invited Sinclair to respond to all the negative studies in humans on resveratrol which have come out since Sinclair published his early work, and then signed a deal with GSK for $720M. Sinclair declined even though the guy is a medical Dr with patients and has legitimate questions, and then blocked him on Twitter. Hardly someone willing to withstand scrutiny or get to the truth of things.


View: https://www.youtube.com/watch?v=vGmmBJq0NNo

 

[BestSinceDAYONE]

Can you explain why you believe that?

Rate of living theory of aging.

Higher t3 levels have been correlated with earlier death.

Think of a whale grows moves very slowly they live extremely long

 

[Hans]

Rate of living theory of aging.

Higher t3 levels have been correlated with earlier death.

Think of a whale grows moves very slowly they live extremely long

Rate of living theory of aging is bunk, and as the name implies, it's just a theory. Many counter facts.
Thryoid hormone T3 doesn't speed up aging.
And whales have very high levels of CO2 which are protective. And as far as I know, no human is a whale or came from a whale.

 

[BestSinceDAYONE]

Rate of living theory of aging is bunk, and as the name implies, it's just a theory. Many counter facts.
Thryoid hormone T3 doesn't speed up aging.
And whales have very high levels of CO2 which are protective. And as far as I know, no human is a whale or came from a whale.

Never said humans were derived from whales...was just an analogy

And yes the jury is still out

 

[joaquin]

That study addresses some of Sinclair's claims. He claims things like metformin and caloric restriction can increase longevity, which this experiment shows. However, aspirin and overeating looks like it's even better. If anything, it looks like Sinclair has a pretty incomplete understanding of longevity.

Sinclair is a salesman.

 

[Herbie]

Agree. Sinclair seems more a marketer and a huckster, than a real follow the evidence scientist. This Dr from New Zealand is also interested in healthy aging and invited Sinclair to respond to all the negative studies in humans on resveratrol which have come out since Sinclair published his early work, and then signed a deal with GSK for $720M. Sinclair declined even though the guy is a medical Dr with patients and has legitimate questions, and then blocked him on Twitter. Hardly someone willing to withstand scrutiny or get to the truth of things.


View: https://www.youtube.com/watch?v=vGmmBJq0NNo

Did he ask where he gets his botox done?

 

[Sicknature]

Agree. Sinclair seems more a marketer and a huckster, than a real follow the evidence scientist. This Dr from New Zealand is also interested in healthy aging and invited Sinclair to respond to all the negative studies in humans on resveratrol which have come out since Sinclair published his early work, and then signed a deal with GSK for $720M. Sinclair declined even though the guy is a medical Dr with patients and has legitimate questions, and then blocked him on Twitter. Hardly someone willing to withstand scrutiny or get to the truth of things.


View: https://www.youtube.com/watch?v=vGmmBJq0NNo

Very interesting

 

[ddjd]

David Sinclair talking about how to extend lifespan. I've seen him making the rounds on the interview circuit (Joe Rogan, Google Talks, etc.) over the past year or so. It looks like he's been getting quite a bit of attention.



9:19 - "Well the clock of aging is due to the loss of information in the cell, and one way to accelerate that is to go break a chromosome. Instead of going in the sun, we've engineered a mouse where we could break its chromosomes. Not enough to cause mutations (the cells put the DNA back together), so we didn't lose any genetic information, but if we're right about the epigenetic information theory of aging, those mice should get old, and that's exactly what happened. Its gray, its got a hunchback, its got dementia, all its organs look old."

12:22 - "The mouse experiments bear this out. The best way to make a mouse live longer is to restrict the time that it eats (so, periodic fasting), to keep it a little cool, and to restrict its amino acids. That's the recipe for long life for a mouse. And it's true for monkeys as well. There have been calorie-restricted studies where these monkeys for 15 years didn't eat as much food as ones that gorged themselves whenever they wanted, and they were protected. They didn't just age slower, they didn't get as much diabetes and heart disease. They were actually fit and healthy.."

The line about the amino acids made me smile. Maybe soon Sinclair will catch up to where Peat was 20 years ago with his view on amino acids and specifically which ones accelerate aging and/or can extend lifespan.

I'm curious if anyone here on the forum has done the Horvath biological clock test?

View: https://twitter.com/TexasLindsay_/status/1632597837237166081?s=20

 

[Osukhan]

View: https://x.com/bradstanfieldmd/status/1766841441093857624?s=46


Most of us know by now Sinclair is a fraud, but I really liked this video to summarize it up

 

[David PS]

@Osukhan - thanks, it is a great summary. Let the buyer beware.