Daily-dose-of-cannabis-extract-could-reverse-brains-decline-in-old-age

LeeLemonoil

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Daily dose of cannabis extract could reverse brain's decline in old age, study suggests


This article as reviewed by "Nature" for almost 2 years, which is rather unusual. Seems like a dogmatic struggle is likely. Anyway, this seems promising, it' not only THC but findings about the role of the endocannabinoid system and it's important role of it in aging and disease.

Has Dr. Peat spoken or written about this receptor system in any form?
 

Hugh Johnson

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The balance between detrimental, pro-aging, often stochastic processes and counteracting homeostatic mechanisms largely determines the progression of aging. There is substantial evidence suggesting that the endocannabinoid system (ECS) is part of the latter system because it modulates the physiological processes underlying aging1, 2. The activity of the ECS declines during aging, as CB1 receptor expression and coupling to G proteins are reduced in the brain tissues of older animals3, 4, 5 and the levels of the major endocannabinoid 2-arachidonoylglycerol (2-AG) are lower6. However, a direct link between endocannabinoid tone and aging symptoms has not been demonstrated. Here we show that a low dose of Δ9-tetrahydrocannabinol (THC) reversed the age-related decline in cognitive performance of mice aged 12 and 18 months. This behavioral effect was accompanied by enhanced expression of synaptic marker proteins and increased hippocampal spine density. THC treatment restored hippocampal gene transcription patterns such that the expression profiles of THC-treated mice aged 12 months closely resembled those of THC-free animals aged 2 months. The transcriptional effects of THC were critically dependent on glutamatergic CB1 receptors and histone acetylation, as their inhibition blocked the beneficial effects of THC. Thus, restoration of CB1 signaling in old individuals could be an effective strategy to treat age-related cognitive impairments.​

https://www.nature.com/nm/journal/vaop/ncurrent/full/nm.4311.html
 

burtlancast

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Anyone remembers the poster who made a thread about cannabis killing neurons, lol?
 
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LeeLemonoil

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Curious thing is, they used osmotic pumps to apply THC to the lab-mice ... don't know how comparable this is to inhalation
 

whodathunkit

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I saw this. Seems like the upshot is that THC makes old people smarter and young people dumber.

"Young people dumber" definitely fits with my existing experience of dope.

Maybe I'll take it up again after I retire, see if the "old people smarter" bit is true, too. :D
 

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