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Cyproheptadine Help

Discussion in 'Cyproheptadine' started by DKBS, May 7, 2015.

  1. DKBS

    DKBS Member

    Joined:
    Oct 11, 2013
    Messages:
    7
    I have worked up to 2 mg Cypro - it is helping with allergies, sleep and I think digestion is improving but I think it is causing fluid retention (feet swelling and weight gain). Any dietary suggestions to offset this? More salt??? Any ideas why?
     
  2. IWishIWasRich

    IWishIWasRich Member

    Joined:
    May 4, 2015
    Messages:
    82
    I also want to know for how long are you supossed to run cypro.
     
  3. Snowdrop

    Snowdrop Member

    Joined:
    Mar 3, 2014
    Messages:
    43
    Sorry I am of no help. I've experienced fluid retention in my feet also. My digestion always improves after 1 week or so on .5mg of Cyproheptadine split to a morning and night dose. However my feet always swell after 1 week of use. No weight gain though.

    Any ideas???
     
  4. Mittir

    Mittir Member

    Joined:
    Feb 20, 2013
    Messages:
    2,034
    Does the feet swelling persists after one week with continued cyprohepatidine doses or do you
    stop taking cypro after that? Did you start with .5 mg dose two times a day from the start
    or did you slowly increased from one dose to two dose? Is it total of 1 mg?

    I started with .5 g once a day and felt quite uncomfortable with drowsiness
    and upset stomach. Stomach problem started after few days, it seems like foods were
    not digested properly and loss of electrolytes . I lowered dose to .25 mg once day and
    slowly increased to .5 mg once or twice a day in few weeks without any problem.
    I now take about 1 mg once or twice a day without any drowsiness or stomach issue.

    One possible mechanism of cypro causing feet swelling could be the lowering of
    Aldosterone, which regulates sodium. If your Aldosterone were already high
    and Cypro is lowering it significantly then loss of sodium can lead to edema.
    Though in practise cypro is used to cure edema. RP has mentioned that
    it takes few days for body to adjust to change in sodium intake by changing
    Aldosterone. Since hypothyroid people have problem maintaining mineral balance
    you can try lower dose of cypro and slowly increase it or continue the dose and
    let thing adjusted on it's own. You can also increase salt intake and maintain
    good intake of other alkaline mineral. Protein intake increases Albumin, which
    plays a big role in preventing edema and maintaining sodium level.
     
  5. Janelle525

    Janelle525 Member

    Joined:
    Sep 13, 2012
    Messages:
    1,955
    I also get fluid retention on cypro, not necessarily in my feet. I asked haidut and he said something having to do with serotonin causing fluid loss and cypro the helps hold on to fluid but the previous answer on aldosterone seems like a better answer.
     
  6. Snowdrop

    Snowdrop Member

    Joined:
    Mar 3, 2014
    Messages:
    43
    I usually push it till 2 weeks, then I stop because I get worried my feet will explode.

    I started on .25 mg once per day for 3 days then increased that to .25 mg morning and night. I have kept this dose for the last 12 days. Feet are still hurting. Sometimes they feel like they are burning, tingling but mostly swollen and sore. I trialled increased salt intake which led to nausea. My temps and pulse are lower.

    I will take it for a further 7 days to see if some balance kicks in.

    Thank you for the ideas everyone.
     
  7. Bart1

    Bart1 Member

    Joined:
    May 21, 2018
    Messages:
    71
    Gender:
    Male
    I also have problems with water retention which increased with using cypro. I don't understand the mechanism you describe. Isn't salt also lowering Aldosterone. Does increase in sodium intake help when Cypro is already lowering Aldosterone.
     
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