Cyproheptadine & Bodybuilding - ZERO Pumps?

[Lokzo]

I have been using Cyproheptadine for the past few days in the evenings, around 4mg.

I have been noticing complete absence/lack of PUMPS in the gym. Literally feel so flat and weak.

What's the actual mechanism of action here?

Thanks!

 

[johnwester130]

lack of nitric oxide ?

 

[Lokzo]

lack of nitric oxide ?

I tried combining with beetroot powder and other vasodilators, but still didn't help at all.

 

[TeaRex14]

Try some pregnenolone, that always gives me a nice pump. Throwing in some high quality vitamin E if you got it, about 100-200ius daily, will combine with the preg real nicely to promote androgen production while inhibiting estrogens at the same time.

 

[AngelZ]

Are the GNC brand Vit E good?

 

[johnwester130]

i heard cypro can deplete dopamine too

 

[Lokzo]

Try some pregnenolone, that always gives me a nice pump. Throwing in some high quality vitamin E if you got it, about 100-200ius daily, will combine with the preg real nicely to promote androgen production while inhibiting estrogens at the same time.

How do you use the Preg?

 

[TeaRex14]

Are the GNC brand Vit E good?

Maybe, haven't used it before so I'm not too keen on the ingredients in the product. It's always good to be skeptical of most E products because a lot of them come with soy oil in them.

How do you use the Preg?

Currently I use 3 drops of StressNon (about 5mgs) on my wrist area, if I were using an oral powder product probably around 50mgs.

 

[Kartoffel]

i heard cypro can deplete dopamine too

I think you shouldn't just throw around with statements like that without backing them up. Some in vitro studies suggest that cyproheptadine in large concentrations can antagonize dopamine receptors, but I haven't seen anything suggesting that this happens in humans, even when it's used in fairly large amounts. In normal amounts its' antagonism to serotonin receptors should increase dopaminergic influence.

 

[TeaRex14]

@johnwester130 @Kartoffel Technically I guess you're both right. In a normal dose, ranging from 1/2mg - 4mgs, cypro could indirectly help dopamine. Antagonizing serotonin and prolactin will help encourage dopamine production. In larger dosages it will lower both serotonin and dopamine. Personally I think cypro is awesome, a wonder supplement for many things. I don't think it helps much in the gym though, anecdotally speaking.

 

[Kartoffel]

@johnwester130 @Kartoffel Technically I guess you're both right. In a normal dose, ranging from 1/2mg - 4mgs, cypro could indirectly help dopamine. Antagonizing serotonin and prolactin will help encourage dopamine production. In larger dosages it will lower both serotonin and dopamine. Personally I think cypro is awesome, a wonder supplement for many things. I don't think it helps much in the gym though, anecdotally speaking.

Do you have any reference for that statement? I have never seen anything suggesting that doses like 12-24mg lower dopamine.

 

[TeaRex14]

Do you have any reference for that statement? I have never seen anything suggesting that doses like 12-24mg lower dopamine.

No I don't, you may want to tag Haidut or PM him about this. I think he knows a lot on the subject. I've just always followed Peat's general recommendation on "safe" cypro dosing. Pretty sure DaveFoster has experimented with larger dosages of cypro in the past, you could ask his take on it too.

 

[Kartoffel]

Ray once wrote this to me in an email: "Yes. I knew a woman who was having menstrual hemorrhages and fainting, who increased it to as much as 28 mg/day, After a few weeks she stopped taking it, and ten years later continues in good health."

 

[TeaRex14]

Ray once wrote this to me in an email: "Yes. I knew a woman who was having menstrual hemorrhages and fainting, who increased it to as much as 28 mg/day, After a few weeks she stopped taking it, and ten years later continues in good health."

So maybe in some specific situations a large dose, taken acutely, may be helpful? I could definitely see that being the case.

 

[rawmeat]

cypro absolutely ruins my workouts if I take anything >1mg the night before. I definitely feel weaker and less motivated after taking it

 

[Andman]

Please keep in mind that gym performance =/= health (esp. from a peat perspective)

 

[Lokzo]

cypro absolutely ruins my workouts if I take anything >1mg the night before. I definitely feel weaker and less motivated after taking it

Exactly right. For some reason it makes my muscles ULTRA weak, zero pump and just plain bad. Even right now, I can barely even get a good contraction at rest....

I thought it may be due to its calcium channel blocking effect?

@haidut?

 

[Lokzo]

Please keep in mind that gym performance =/= health (esp. from a peat perspective)

Very good point - I go to the gym to prevent insulin resistance/build muscle, which indirectly yields benefits to overall health and metabolic efficiency.

 

[bromuda]

Salt is pretty good, gets me sick pumps

 

[Andman]

Very good point - I go to the gym to prevent insulin resistance/build muscle, which indirectly yields benefits to overall health and metabolic efficiency.

yeah me too bro, but consider this - to achieve big lifts/high reps in the gym one needs to tap into the sympathetic nervous system (thats why its hard to lift a max. weight without warm up sets for example)
cypro is very good at turning off the stress response/sympathetic activation, thats kinda why we love it so much