Cyproheptadine Blocks Cortisol Excess Due To Hypoglycemia / Estrogen

[haidut]

Have you seen any of those studies using low doses? 12-16mg cypro would knock me the f*** out for days. Moon face, high cortisol is a problem i have

The lowest I have seen used for Cushing is 8mg daily.

 

[forterpride]

So can you guys elaborate on what an entry dose would be to experiment with? And do we just try it when we are stressed or is this a daily thing like the methlyn blue that has to build up?

 

[superhuman]

The lowest I have seen used for Cushing is 8mg daily.

Ahh ok. I remember RP told me 0.5mg cypro was used for allergies etc, 1mg for depression and 2mg for cancer etc.
Allergies, depression etc are all linked to high histamine, adrenaline, cortisol etc ? so it should help in those dosages i guess

 

[haidut]

Ahh ok. I remember RP told me 0.5mg cypro was used for allergies etc, 1mg for depression and 2mg for cancer etc.
Allergies, depression etc are all linked to high histamine, adrenaline, cortisol etc ? so it should help in those dosages i guess

I think even the lower doses should help for cortisol but it may take longer to feel the effects. Th studies with higher doses were done in a clinical setting where doctors try to treat the issue ASAP, hence the higher dose.

 

[superhuman]

@haidut thanx man. I feel cascara also helps. I take 1 cap 3 times a day now and i can see that i have less water retention in face and legs

 

[paymanz]

Two weeks ago I decided to take 0.25mg of cyproheptadine in the evening to ward off mild cold/flu like symptoms and within seconds experienced dangerously low blood sugar symptoms (i.e. sudden drastic drop in temperature, high blood pressure, sweaty palms, head rush, panic). I've had similar experiences when taking anything that lowers blood sugar and/or stress hormones like 5mg biotin, >100mg pregnenolone and >2mg DHEA.

It reminded me to support thyroid function with T3/T4 (<100mg pregnenolone works brilliantly too) when concurrently taking something like cyproheptadine to lower excess stress hormones.

so if you get those symptoms of hypoglacemia by taking biotin,dhea,... then it should be worst to take t3?!

 

[energyandstruct]

Another good study demonstrating that very tight relationship between serotonin, estrogen and cortisol. In light of all this evidence I am not sure how can anyone call serotonin the happiness hormone, or recommend estrogen for menopause....These things are pure poison (metabolically speaking).
Anyways, moderate doses (12mg - 16mg for 2 days) of cyproheptadine FULLY blunted the cortisol response to hypoglycemia. In other words, cyproheptadine is capable of fully blocking the stress response (of starvation at least).
Perhaps even more importantly, the study included two patients taking estrogenic birth control pills. As you can see, their baseline plasma cortisol was already much higher than normal. It was as if these women were under constant hypoglycemia, as their BASELINE cortisol was really high and close to Cushing syndrom levels. Also, in these women hypoglycemia could not raise cortisol much higher indicating they were under enouhg stress already. So, people with high estrogen are under constant state of stress due to their high baseline cortisol levels. Cyproheptadine had a strikingly beneficial effect on their cortisol as well.
Thus, one more point for Ray saying that estrogen raises cortisol and is directly implicated in insulin resistance and diabetes.

Inhibition of hypoglycemia-induced cortisol secretion by the serotonin antagonist cyproheptadine. - PubMed - NCBI

"...Cyproheptadine administration resulted in a 31% reduction in the area under the cortisol curve. If cyproheptadine acts by antagonizing serotonin, these studies suggest that serotonin may be involved in hypoglycemia-induced cortisol secretion in man."

"...Cyproheptadine administration markedly reduced the peak concentration of plasma cortisol. The mean fasting concentration after treatment was 10mcg/100ml, a value which was not significantly different from the fasting concentration in the controls. At 30, 40, 50, 60, and 90min there was a statistically significant difference from the pre-treatment test. The peak cortisol concentration of 13mcg/100ml was not statistically different from the post-treatment fasting concentration of 10mcg/100ml. From this data it is evident that the peak cortisol response to insulin hypoglycemia is completely obliterated by cyproheptadine administration."

"...There was a 31% reduction in the total area under the cortisol curves after cyproheptadine administration. This reduction was due to blockade of hypoglycemia-stimulated cortisol secretion, for the baseline steroid concentration was not altered, and it was only the superimposed cortisol peak that was changed."

"...The 2 gilrs on birth control pills were considered separately and not included in the above calculation. Their pretreatment control cortisol levels were much higher (28mcg/100ml and 41 mcg/100ml) than the rest of the volunteers and the percent increment in the cortisol concentration with hypoglycemia was not as great. In the post treatment tests their fasting concentrations fell to 11mcg/100ml and 26mcg/100ml, respectively. The percent reduction in the areas under their curves was 10% and 79% respectively."

are those doses considered moderate? I started with basically like .5mg cypro and have gotten a tolerance, so now sometimes when i take over four mg it doesn't do much and i wonder about going higher

 

[haidut]

are those doses considered moderate? I started with basically like .5mg cypro and have gotten a tolerance, so now sometimes when i take over four mg it doesn't do much and i wonder about going higher

I think the 8mg+ doses are probably only needed for severe cortisol issues like Cushing or from cancer. Other than that, 1mg-2mg daily is plenty for most people.

 

[LUH 3417]

are those doses considered moderate? I started with basically like .5mg cypro and have gotten a tolerance, so now sometimes when i take over four mg it doesn't do much and i wonder about going higher

When I take cypro alone I don’t feel anything from even 8mg. When I take it with progesterone 1mg makes me feel very calm.

 

[energyandstruct]

I think the 8mg+ doses are probably only needed for severe cortisol issues like Cushing or from cancer. Other than that, 1mg-2mg daily is plenty for most people.

I’m getting severe mast cell issues and mold reactivity and 2 mg not cutting it for me, that used to be a big dose for me. What are the side effects of the higher doses

 

[haidut]

I’m getting severe mast cell issues and mold reactivity and 2 mg not cutting it for me, that used to be a big dose for me. What are the side effects of the higher doses

A simple search for "cyproheptadine side effects" either here or on Google would answer your questions.