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Cyproheptadine: "An Optimal Dose Of 80 Mg/day"

Discussion in 'Scientific Studies' started by cjm, Mar 14, 2019.

  1. cjm

    cjm Member

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    Carcinoid myopathy and treatment with cyproheptadine (Periactin)

    "Vroom, Brown, Dempsey, Richardson Hill (1962) reported the beneficial effects of cyproheptadine, using an optimal dose of 80 mg/day, in controlling diarrhea and improving well being."

    The dose in the linked study was 16 - 32 mg/day, which was the highest I had heard until I actually read the study. Would love access to the 80/mg study if anyone has it. Link below.

    Studies on Several Possible Antiserotonin Compounds in a Patient with the Functioning Carcinoid Syndrome
     
  2. firebreather

    firebreather Member

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    Seems like that would cause some serious weight gain
     
  3. Kartoffel

    Kartoffel Member

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  4. Kartoffel

    Kartoffel Member

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    Seems like cypro is really the way to go when you have carcinoid snydrome

    upload_2019-3-17_19-5-17.jpeg
     
  5. firebreather

    firebreather Member

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  6. Kartoffel

    Kartoffel Member

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    As I said, it does increase appetite but I haven't seen anything suggesting a linear relationship above a certain dosage - i.e. 80mg might not induce more increased appetite/weight gain than 4-10mg.
     
  7. aguilaroja

    aguilaroja Member

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    "While both chlorpromazine and cyproheptadine were clinically effective, cyproheptadine, administered for more than one year, effected a more marked reversal of clinical symptomatology."

    It is interesting that another early anti-histamine, chlorpheniramine, did not relieve diarrhea in the case report. This suggests that the strong anti-cholinergic effects of first generation anti-histamines do not relieve the diarrhea of serotonin excess. It may be only the anti-histamines with anti-serotonin action, like cyproheptadine, provide relief.
     
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