Cyproheptadine 8 Grams Twice A Day

[biggirlkisss]

Cyproheptadine 8 grams twice a day could too much backfire like antihistamines or is more better.

 

[ecstatichamster]

8 grams is not right. 8 MILLI grams but that is two full pills, quite a lot. More than I would ever take.

 

[biggirlkisss]

what about Clomipramine is a reuptake inhibitor of serotonin and norepinephrine, or a serotonin–norepinephrine reuptake inhibitor (SNRI); that is, it blocks the reuptake of these neurotransmitters back into neurons by preventing them from interacting with their transporters, thereby increasing their extracellular concentrations in the synaptic cleft and resulting in increased serotonergic and noradrenergic neurotransmission.[46][34] In addition, clomipramine also has antiadrenergic, antihistamine, antiserotonergic, antidopaminergic, and anticholinergic activities. It is specifically an antagonist of the α1-adrenergic receptor, the histamine H1 receptor, the serotonin 5-HT2A, 5-HT2C, 5-HT3, 5-HT6, and 5-HT7 receptors, the dopamine D1, D2, and D3 receptors, and the muscarinic acetylcholine receptors (M1–M5).

the only thing bad is anti dopaminegic correct? ecstatic hamster

 

[aguilaroja]

what about Clomipramine is a reuptake inhibitor of serotonin and norepinephrine, or a serotonin–norepinephrine reuptake inhibitor (SNRI); that is, it blocks the reuptake of these neurotransmitters ...resulting in increased serotonergic and noradrenergic neurotransmission.[46][34] In addition, clomipramine also has antiadrenergic, antihistamine, antiserotonergic, antidopaminergic, and anticholinergic activities. It is specifically an antagonist of ...the serotonin 5-HT2A, 5-HT2C, 5-HT3, 5-HT6, and 5-HT7 receptors....

the only thing bad is anti dopaminegic correct? ecstatic hamster

While Clomipramine is said to inhibit reuptake of serotonin and norepinephrine, it is not always regarded as an SNRI, like Effexor and Cymbalta. Clomipramine is in the tricyclic antipressant group, though its actions may differ considerably from other agents in the group:
Tricyclic antidepressant - Wikipedia

Due to the serotonin reuptake action, Clomipramine is thought to functionally boost brain serotonin, even with the stated antagonism to serotonin binding sites. Excess clomipramine can cause Serotonin syndrome.

Clomipramine - Wikipedia
"The exceptionally strong serotonin reuptake inhibition of clomipramine likely precludes the possibility of its antagonism of serotonin receptors (which it binds to with more than 100-fold lower affinity than the SERT) resulting in a net decrease in signaling by these receptors. In accordance, while serotonin receptor antagonists like cyproheptadine and chlorpromazine are effective as antidotes against serotonin syndrome,[55][56] clomipramine is nonetheless capable of inducing this syndrome.[53]"

 

[biggirlkisss]

thanks cpyrohedine sounds the best.