Crickets Fed Low Dose Aspirin Live 143% Longer, Have Longer Childhoods And Higher Metabolic Rates

Based Kantian

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We examined the impacts of aspirin and metformin on the life history of the cricket Acheta domesticus (growth rate, maturation time, mature body size, survivorship, and maximal longevity). Both drugs significantly increased survivorship and maximal life span. Maximal longevity was 136 days for controls, 188 days (138 % of controls) for metformin, and 194 days (143 % of controls) for aspirin. Metformin and aspirin in combination extended longevity to a lesser degree (163 days, 120 % of controls). Increases in general survivorship were even more pronounced, with low-dose aspirin yielding mean longevity 234 % of controls (i.e., health span). Metformin strongly reduced growth rates of both genders (<60 % of controls), whereas aspirin only slightly reduced the growth rate of females and slightly increased that of males. Both drugs delayed maturation age relative to controls, but metformin had a much greater impact (>140 % of controls) than aspirin (~118 % of controls). Crickets maturing on low aspirin showed no evidence of a trade-off between maturation mass and life extension. Remarkably, by 100 days of age, aspirin-treated females were significantly larger than controls (largely reflecting egg complement). Unlike the reigning dietary restriction paradigm, low aspirin conformed to a paradigm of “eat more, live longer.” In contrast, metformin-treated females were only ~67 % of the mass of controls. Our results suggest that hormetic agents like metformin may derive significant trade-offs with life extension, whereas health and longevity benefits may be obtained with less cost by agents like aspirin that regulate geroprotective pathways.

Impacts of metformin and aspirin on life history features and longevity of crickets: trade-offs versus cost-free life extension?
 

LeeLemonoil

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Wow. Only crickets but very Peaty. Aspirin universals beneficial while celebrated Metformin comes at a price for its benefits
 

Hugh Johnson

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From what I can tell, Metformin mimics starvation, and this leads the test animals to grow smaller and develop slower. This means they live longer, via the same mechanism that makes small dogs live longer.

However, this is only possible because they are not in competition, where small size would probably get them killed. In defence of Metformin, the modern diet and lifestyle is so toxic that people may often live with chronic energy production deficit, and Metformin could be adaptable. Aspirin and coconut oil would of course help solve the actual issue...
 

haidut

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We examined the impacts of aspirin and metformin on the life history of the cricket Acheta domesticus (growth rate, maturation time, mature body size, survivorship, and maximal longevity). Both drugs significantly increased survivorship and maximal life span. Maximal longevity was 136 days for controls, 188 days (138 % of controls) for metformin, and 194 days (143 % of controls) for aspirin. Metformin and aspirin in combination extended longevity to a lesser degree (163 days, 120 % of controls). Increases in general survivorship were even more pronounced, with low-dose aspirin yielding mean longevity 234 % of controls (i.e., health span). Metformin strongly reduced growth rates of both genders (<60 % of controls), whereas aspirin only slightly reduced the growth rate of females and slightly increased that of males. Both drugs delayed maturation age relative to controls, but metformin had a much greater impact (>140 % of controls) than aspirin (~118 % of controls). Crickets maturing on low aspirin showed no evidence of a trade-off between maturation mass and life extension. Remarkably, by 100 days of age, aspirin-treated females were significantly larger than controls (largely reflecting egg complement). Unlike the reigning dietary restriction paradigm, low aspirin conformed to a paradigm of “eat more, live longer.” In contrast, metformin-treated females were only ~67 % of the mass of controls. Our results suggest that hormetic agents like metformin may derive significant trade-offs with life extension, whereas health and longevity benefits may be obtained with less cost by agents like aspirin that regulate geroprotective pathways.

Impacts of metformin and aspirin on life history features and longevity of crickets: trade-offs versus cost-free life extension?

Great find, thanks.
Here is an even more dramatic result, in another animal model. I wish they would do one in rodents but those live several years and such a study would be very expensive.
Aspirin Pro-Drug From Willow Bark Extends Yeast Lifespan By Almost 400%
 

Cloudhands

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I think low doses are important too. Gerald Pollack did expiriments testing the EZ in water with different solids in the water, and many of them, including aspirin, peaked at lower amounts and then diminished with anymore after a certain point. Im not sure where this would be for humans, but its a starting point.
 
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