COVID-19 Should Be A Methylene Blue “promoter”

[Orome]

"Should MB, a precursor to hydroxychloroquine, be a “rescue magic bullet” against the new coronavirus?"

https://cdn.publisher.gn1.link/bjcvs.org/pdf/0102-7638-rbccv-35-04-0604.pdf

 

[rzero]

Interesting. I did not know MB was a precursor to hydroxychloroquine.

 

[rei]

Indeed, i would like to know more of this aspect, in what sense a precursor? Metabolically? Or just as one step in a long laboratory synthesis process?

 

[snacks]

Interesting. I did not know MB was a precursor to hydroxychloroquine.

From context, I think he's talking about MB predating HCQ as a malarial drug?

 

[rzero]

From context, I think he's talking about MB predating HCQ as a malarial drug?

Oh, that makes sense.

 

[Jam]

From methylene blue to chloroquine: A brief review of the development of an antimalarial therapy

"... and devised a new compound in which
one methyl group was replaced by an aminoalkyl group.
Scientists at Bayer began synthesizing a large number
of compounds, the most successful of which was termed
quinacrine (subsequently marketed as mecaprine and
atabrine), which they synthesized in 1931."

"In July, 1934, Andersag modified atabrine by replac-
ing its acridine ring with a quinoline ring. The resulting
compound, which would later be termed chloroquine
(Fig. 3c), was found to have high antimalarial activity,
and unlike methylene blue or atabrine, did not discolor
skin and eyes."