• Due to excessive bot signups along with nefarious actors we are limiting forum registration. Keep checking back for the register link to appear. Please do not send emails or have someone post to the forum asking for a signup link. Until the current climate changes we do not see a change of this policy. To join the forum you must have a compelling reason. Letting us know what skills/knowledge you will bring to the community along with the intent of your stay here will help in getting you approved.

haidut

Member
Joined
Mar 18, 2013
Messages
18,214
Location
USA / Europe
Yet another seemingly non-metabolic disease turns out to be nothing but energy deficiency in disguise. Apparently, the SARS-CoV-2 virus selectively disables so-called complex I of the electron transport chain (ETC), and as such the overall OXPHOS process. Such inhibition is known to reliably increase the production of reactive oxygen species (ROS), which is known to lead to lipid peroxidation, hypercoagulation, and eventually cytokine storm in the most energetically compromised patients. As the study authors state, this explains why certain people with chronic conditions are at increased risk of severe COVID-19 or death - i.e. they are already in an energetically compromised state and COVID-19 greatly exacerbates the existing energetic deficiency. This suggests that chemicals like methylene blue (MB), which can bypass (and often rectify) complex I issues may be a viable treatment (and possibly prevention as well) for COVID-19, especially in already energetically compromised patients. MB has already been shown to be able to directly kill the virus, which makes it that much more appropriate as a therapeutic intervention. Unfortunately, the ongoing human clinical trials with MB for COVID-19 use very high doses (100mg several times daily), which increase the risk of elevating serotonin and the latter is already known to be a major risk factor for COVID-19 exacerbation and/or subsequent death. Considering most human trials with MB found no benefit beyond 15mg daily (even for a severe disease such as Alzheimer's), I think a much more sensible approach would be to take say 5mg and spend a few hours in the sun, thus implementing the so-called photodynamic therapy, which Pfizer recently patented as a viable treatment for cancer.

https://doi.org/10.1038/s41598-020-79552-z
"...Seeking to understand why COVID-19 is able to suppress the body’s immune response, new research from the USC Leonard Davis School of Gerontology suggests that mitochondria are one of the first lines of defense against COVID-19 and identifies key differences in how SARS-CoV-2, the virus that causes COVID-19, affects mitochondrial genes when compared to other viruses. These differences offer possible explanations as to why older adults and people with metabolic disfunction have more severe responses to COVID-19 than other individuals and they also provide a starting point for more targeted approaches that may help identify therapeutics, says senior author Pinchas Cohen, professor of gerontology, medicine and biological sciences and dean of the USC Leonard Davis School. “If you already have mitochondrial and metabolic dysfunction, then you may, as a result, have a poor first line of defense against COVID-19. Future work should consider mitochondrial biology as a primary intervention target for SARS-CoV-2 and other coronaviruses,” he said. The study, published in the Nature journal Scientific Reports, expands on recent findings that COVID-19 mutes the body’s innate inflammatory response and reports that it does so by diverting mitochondrial genes from their normal function.

"...“We already knew that our immune response was not mounting a successful defense to COVID-19, but we didn’t know why,” said lead author Brendan Miller, a senior doctoral student at the USC Leonard Davis School. “What we did differently was look at how the virus specifically targets mitochondria, a cellular organelle that is a crucial part of the body’s innate immune system and energy production.”

"...Chief among their findings is that SARS-CoV-2 uniquely reduces the levels of a group of mitochondrial proteins, known as Complex One, that are encoded by nuclear DNA."
 

tygreezytlb

Member
Joined
Jul 23, 2020
Messages
59
I had an extreme reaction to mb, after one drop, of pharma grade, I think people should be careful with it but it more than likely helps.
 

Steve

Member
Joined
Nov 9, 2016
Messages
395
My friend's wife is still using a portable oxygen machine months after getting Covid. I'm guessing six months now. Would the lungs and low oxygen readings fall under this energy deficiency scenario?
 

mostlylurking

Member
Joined
May 13, 2015
Messages
1,176
Location
Texas
Yet another seemingly non-metabolic disease turns out to be nothing but energy deficiency in disguise. Apparently, the SARS-CoV-2 virus selectively disables so-called complex I of the electron transport chain (ETC), and as such the overall OXPHOS process. Such inhibition is known to reliably increase the production of reactive oxygen species (ROS), which is known to lead to lipid peroxidation, hypercoagulation, and eventually cytokine storm in the most energetically compromised patients. As the study authors state, this explains why certain people with chronic conditions are at increased risk of severe COVID-19 or death - i.e. they are already in an energetically compromised state and COVID-19 greatly exacerbates the existing energetic deficiency. This suggests that chemicals like methylene blue (MB), which can bypass (and often rectify) complex I issues may be a viable treatment (and possibly prevention as well) for COVID-19, especially in already energetically compromised patients. MB has already been shown to be able to directly kill the virus, which makes it that much more appropriate as a therapeutic intervention. Unfortunately, the ongoing human clinical trials with MB for COVID-19 use very high doses (100mg several times daily), which increase the risk of elevating serotonin and the latter is already known to be a major risk factor for COVID-19 exacerbation and/or subsequent death. Considering most human trials with MB found no benefit beyond 15mg daily (even for a severe disease such as Alzheimer's), I think a much more sensible approach would be to take say 5mg and spend a few hours in the sun, thus implementing the so-called photodynamic therapy, which Pfizer recently patented as a viable treatment for cancer.

https://doi.org/10.1038/s41598-020-79552-z
"...Seeking to understand why COVID-19 is able to suppress the body’s immune response, new research from the USC Leonard Davis School of Gerontology suggests that mitochondria are one of the first lines of defense against COVID-19 and identifies key differences in how SARS-CoV-2, the virus that causes COVID-19, affects mitochondrial genes when compared to other viruses. These differences offer possible explanations as to why older adults and people with metabolic disfunction have more severe responses to COVID-19 than other individuals and they also provide a starting point for more targeted approaches that may help identify therapeutics, says senior author Pinchas Cohen, professor of gerontology, medicine and biological sciences and dean of the USC Leonard Davis School. “If you already have mitochondrial and metabolic dysfunction, then you may, as a result, have a poor first line of defense against COVID-19. Future work should consider mitochondrial biology as a primary intervention target for SARS-CoV-2 and other coronaviruses,” he said. The study, published in the Nature journal Scientific Reports, expands on recent findings that COVID-19 mutes the body’s innate inflammatory response and reports that it does so by diverting mitochondrial genes from their normal function.

"...“We already knew that our immune response was not mounting a successful defense to COVID-19, but we didn’t know why,” said lead author Brendan Miller, a senior doctoral student at the USC Leonard Davis School. “What we did differently was look at how the virus specifically targets mitochondria, a cellular organelle that is a crucial part of the body’s innate immune system and energy production.”

"...Chief among their findings is that SARS-CoV-2 uniquely reduces the levels of a group of mitochondrial proteins, known as Complex One, that are encoded by nuclear DNA."
Regarding Reactive Oxygen Species and Thiamine, I found this:

Thiamine protects against paraquat-induced damage: scavenging activity of reactive oxygen species - PubMed Z: Thiamine protects against paraquat-induced damage: scavenging activity of reactive oxygen species:

"In conclusion, this evidence suggests that thiamine may partly act as an antioxidant to scavenge O(2)(-) (or OH) directly and thus affect the cellular response to oxidative stress induced by reactive oxygen species. "

Also, here's an article: Thiamine: A Missing Piece of the COVID-19 Treatment Puzzle? - Hormones Matter
 
Similar threads
Thread starter Title Forum Replies Date
Braveheart COVID-19? Survival Requires Energy Viruses, Parasites, Fungus, Vaccines 5
David PS Yogic-humming: A Respiratory Defense Booster for COVID (and Close-Encounters of the Shedding Kind?) Viruses, Parasites, Fungus, Vaccines 3
L Ethyl Pyruvate as a Potential Defense Intervention against Cytokine Storm in COVID-19? Supplements, Pharmaceutical Drugs 0
aliml Higher intakes of calcium and dairy products were associated with increased odds of COVID-19 infection Articles & Scientific Studies 4
L Potential for the Repurposing of Adamantane Antivirals for COVID-19 Supplements, Pharmaceutical Drugs 0
Pina "Fundamentally Evil" - COVID Policies Harming Children Viruses, Parasites, Fungus, Vaccines 0
F COVID mRNA Shots Are A ‘Technology Designed To Poison People’ Society 1
B Arsenic, Free Masons and Covid Ask For Help or Advice 16
M Those who think covid does not exist or is much harmless - pls debate some people with other opinions! Ask For Help or Advice 203
Hugh Johnson Mass formation by Mattias Desmet, or why the people still believe the COVID narrative no matter how absurd Society 10
M Friend lost his smell and taste after covid. Did something really help for this in here ? Ask For Help or Advice 40
L New insights into genetic susceptibility of COVID-19 an ACE2 and TMPRSS2 polymorphism analysis Viruses, Parasites, Fungus, Vaccines 5
aliml Post-Traumatic Stress Disorder as an Endothelial Disease: Insights From COVID-19 Articles & Scientific Studies 1
youngsinatra COVID-19 Mortality Rate Close to Zero Could Theoretically Be Achieved at 50 ng/mL 25(OH)D3: Results of a Systematic Review and Meta-Analysis Vitamins 10
ecstatichamster New supposed Covid-19 variant Nu Omicron found 21-November 2021 only in vaccinated people in Botswana Viruses, Parasites, Fungus, Vaccines 23
aliml Is carbonic anhydrase inhibition useful as a complementary therapy of Covid-19 infection? Scientific Studies 5
N Prescribed Amitriptyline by Post COVID Clinic, thoughts? Supplements, Pharmaceutical Drugs 29
Grapelander What Does All-Cause Mortality Tell Us About The Covid Pandemic? Viruses, Parasites, Fungus, Vaccines 2
Drareg Botswana Covid variant New Vaccines 71
R Minerals and vitamins that act like blood thinning agents-hack ,,covid injections" Heart, Heart Rate, Blood Pressure 22
Braveheart A Theory As To Why COVID Cases Started Skyrocketing In Central Europe Last Month Viruses, Parasites, Fungus, Vaccines 31
haidut Experts: Japan's lack of COVID-19 pandemic due to the virus "mutating out of existence" Vaccines 38
M Tim Pool on him catching Covid Ask For Help or Advice 19
Kvothe Mrna COVID Vaccines Dramatically Increase Endothelial Inflammatory Markers and ACS Risk as Measured by the PULS Cardiac Test: a Warning Viruses, Parasites, Fungus, Vaccines 5
Lokzo Does serotonin deficiency lead to anosmia, ageusia, dysfunctional chemesthesis and increased severity of illness in COVID-19? Scientific Studies 23
Braveheart Scientists mystified, wary, as Africa avoids COVID disaster Viruses, Parasites, Fungus, Vaccines 11
Jam Horowitz: Are elites planning a COVID repeat ... with smallpox? Breaking News 21
Braveheart Covid Jab Is Far More Dangerous than Advertised. Dr. Peter McCullough Vaccines 0
Drareg FDA Asks Federal Judge to Grant it Until the Year 2076 to Fully Release Pfizer’s COVID-19 Vaccine Data Vaccines 13
R Non Covid vax for 4 year old protocol Vaccines 12
L Another B3 helps treat Covid study B3/Niacinamide 2
Braveheart Fauci, Gates Admit COVID Vaccines Don’t Work as Advertised Vaccines 12
Braveheart COVID-19-vaccines-Continuing-the-long-history-of-medical-experimentation-on-children Vaccines 0
ddjd 128 Research Studies confirm efficacy of natural immunity versus COVID-19 vaccine induced immunity: Documented, Linked, and Quoted Ask For Help or Advice 0
frannybananny Artemisia against Covid Articles & Scientific Studies 6
Braveheart Feds Pay Zero Claims For Covid-19 Vaccine Injuries/Deaths Vaccines 7
Braveheart CAUGHT: NBC's Outrageous Lies About Covid & Child Vaxx Vaccines 1
Drareg Michael P. Singer COVID/China Viruses, Parasites, Fungus, Vaccines 8
Sam321 Study shows dramatic decline in effectiveness of all three COVID-19 vaccines over time Breaking News 9
Pina Big Brother Watch Legal Challenge Welsh Covid Passport Vaccines 1
aliml The potential use of lactate blockers for the prevention of COVID-19 worst outcome, insights from exercise immunology Scientific Studies 1
Braveheart Technocensorship: Rutherford Institute Challenges Facebook's Censorship of COVID-19 Vaccine Critics Vaccines 0
J A very informative video about Covid-19 and treatment modalities Viruses, Parasites, Fungus, Vaccines 1
H Pfizer claiming to have an 89% effective covid antiviral Pharmaceutical Drugs 27
haidut Italy admits 97%+ of COVID-19 deaths were not *FROM* the virus Society 28
N Microclotting Causing Long COVID Viruses, Parasites, Fungus, Vaccines 86
P Nature article, COVID and A1c Blood Sugar 6
JudiBlueHen VAXART - the next COVID vaccine Supplements, Pharmaceutical Drugs 16
Jam "A Tonic Water a Day Keeps The COVID-19 Away" Viruses, Parasites, Fungus, Vaccines 16
H CDC data "shows" vaccines 5x more effective than prior COVID-19 infections Vaccines 3

Similar threads

Top