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COVID-19 And Metabolic Syndrome – An Association Too DIfficult To Ignore

Mito

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Dec 10, 2016
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2,388
A recent meta-analysis from China involving 46,248 patients showed that the most prevalent co-morbidity in people infected by COVID-19 was hypertension (17±7, 95% confidence interval [CI] 14–22%) followed by diabetes (8±6, 95% CI 6–11%), cardiovascular diseases (5±4, 95% CI 4–7%) and respiratory diseases (2±0, 95% CI 1–3%), which surprisingly comes much later than the components of metabolic syndrome.3 Patients with severe disease were 2.36 times more likely to have hypertension (95% CI 1.46–3.83), 2.46 times like to have respiratory disease (95% CI 1.76–3.44) and 3.42 times likely to have underlying cardiovascular disease (95% CI 1.88–6.22), as compared to those with mild disease not needing hospital admission.3 In a cohort of 54 critically ill patients admitted with COVID-19 pneumonia in China, 44.4%, 24.1% and 14.8% patients had pre-existing hypertension, diabetes and coronary heart disease, respectively.4 Of these, 44.4% of patients were complicated with myocardial injury as evidenced by raised cardiac enzymes, and N-terminal pro-B-type natriuretic peptide. These patients had a very high mortality of 48.1%.4 In another cohort of 131 patients with COVID-19 infection admitted at a hospital in Wuhan, hypertension was the most common associated comorbidity (30%), followed by diabetes (19%) and coronary artery disease (8%).5”
COVID-19 and Metabolic Syndrome – An Association too Difficult to Ignore – touchENDOCRINOLOGY
 

Lejeboca

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Joined
Jun 19, 2017
Messages
878
A recent meta-analysis from China involving 46,248 patients showed that the most prevalent co-morbidity in people infected by COVID-19 was hypertension (17±7, 95% confidence interval [CI] 14–22%) followed by diabetes (8±6, 95% CI 6–11%), cardiovascular diseases (5±4, 95% CI 4–7%) and respiratory diseases (2±0, 95% CI 1–3%), which surprisingly comes much later than the components of metabolic syndrome.3 Patients with severe disease were 2.36 times more likely to have hypertension (95% CI 1.46–3.83), 2.46 times like to have respiratory disease (95% CI 1.76–3.44) and 3.42 times likely to have underlying cardiovascular disease (95% CI 1.88–6.22), as compared to those with mild disease not needing hospital admission.3 In a cohort of 54 critically ill patients admitted with COVID-19 pneumonia in China, 44.4%, 24.1% and 14.8% patients had pre-existing hypertension, diabetes and coronary heart disease, respectively.4 Of these, 44.4% of patients were complicated with myocardial injury as evidenced by raised cardiac enzymes, and N-terminal pro-B-type natriuretic peptide. These patients had a very high mortality of 48.1%.4 In another cohort of 131 patients with COVID-19 infection admitted at a hospital in Wuhan, hypertension was the most common associated comorbidity (30%), followed by diabetes (19%) and coronary artery disease (8%).5”
COVID-19 and Metabolic Syndrome – An Association too Difficult to Ignore – touchENDOCRINOLOGY

Couple this with the studies that PUFA levels in serum are a reliable biomarker for COVID-19, as haidut posted on his website
COVID-19/SARS may be due simply to serum PUFA and its peroxidation – To Extract Knowledge from Matter

and the picture becomes even more clear; the answers to why the younger population is `on ventilators' start to emerge...
 

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