haidut

Member
Joined
Mar 18, 2013
Messages
17,440
Location
USA / Europe
As many forum users probably know, glucocorticoid treatment is one of the main lines of therapies in cancer. It is considered highly beneficial due to reducing inflammation and swelling/pain in inflamed/cancerous tissue. However, recent studies have shown that immune dysfunction is perhaps the main reason behind the initiation and progression of cancer, and that restoring immune activity may be as simple as blocking estrogen.
Immune Decline (Not Genetics) Causes Cancer And It Can Be Easily Fixed
Reducing Estrogen Synthesis Regenerates Thymus Destroyed By Aging

Considering that glucocorticoid are the most potent agents known for destroying the thymus gland (i.e. thymolytic), and that glucocorticoids are among the most potent inducers of estrogen synthesis, it seems that administering glucocorticoid to cancer patients would be a rather bad idea.
The study below corroborates this idea and suggests that glucocorticoid therapy in cancer could be rather dangerous except in a very small proportion of patients.

Corticosteroid co-treatment induces resistance to chemotherapy in surgical resections, xenografts and established cell lines of pancreatic cancer. - PubMed - NCBI
"...In conclusion, we show by in vitro,ex vivo and in vivo studies that application of DEX renders pancreatic cancer cells resistant to apoptosis and promotes proliferation following cytotoxic therapy. This is in contrast to the effect of GCs in lymphoid cells and may involve cell type specific regulation of survival molecules such as SGK-1 and MKP-1 together with anti-apoptotic molecules such as X-IAP and Bcl-2. Thus, while some properties of GCs may be of benefit, induction of resistance in tumour cells towards cancer therapy may be dangerous for patients. Prospective clinical studies which do not exist until now, are urgently needed."
 

haidut

Member
Thread starter
Joined
Mar 18, 2013
Messages
17,440
Location
USA / Europe

I disagree.
Comparison of the effect of cortisol on aromatase activity and androgen metabolism in two human fibroblast cell lines derived from the same individ... - PubMed - NCBI
Cortisol induces aromatase expression in human placental syncytiotrophoblasts through the cAMP/Sp1 pathway. - PubMed - NCBI
https://joe.bioscientifica.com/downloadpdf/journals/joe/158/3/401.xml
http://press.endocrine.org/doi/abs/10.1210/endo-meetings.2016.TB.1.FRI-069

Btw, the studies you posted do not show corticoids decreasing aromatase. They talk about the GR receptors and show cortisol sometimes antagonizes the ER. That is not the same as inhibiting aromatase. As far as estrogen - if estrogen blocks the GR then it does not induce GR resistance but actually treats it. Agonists induce resistance by downregulating a receptor, so if estrogen inhibits GR then it is an antagonist. RU486 is a GR antagonist and it is used to reverse GR resistance.
Finally, in Cushing syndrome (excess cortisol) about 80% of the male patients have gyno. Gyno is caused by estrogen/prolactin, so the high cortisol in those patients must be increasing estrogen/prolactin somehow, which matches what I mentioned before and the studies I posted.
 
Similar threads
Thread starter Title Forum Replies Date
J Best way to deal with hypoglycemia due to low cortisol? Blood Sugar 1
E Morning blood cortisol 640 nmol/L Cortisol, Serotonin, Histamine 0
Hans How to lower intracellular cortisol Articles & Scientific Studies 11
T Adrenal fatigue: Best methods to increase cortisol naturally Cortisol, Serotonin, Histamine 18
F ""Low Serum AM Cortisol The Cause Of My Problems?"" Doubts About Milk 70
N Extremely High Cortisol Ask For Help or Advice 4
S Raising cortisol while on low carb Cortisol, Serotonin, Histamine 4
haidut Heart attack survivors have high stress (cortisol/adrenaline) hypersensitivity, low androgens Scientific Studies 2
haidut Fasting ups estrogen & cortisol, decimates vitamin D, may cause diabetes Scientific Studies 12
haidut Vitamin D prevents cortisol-induced depression and...inflammation Scientific Studies 0
haidut Vitamin D is anti-catabolic / anabolic, protects liver from cortisol injury Scientific Studies 2
ddjd Testosterone agonises 11-beta-HSD-1 i.e. raising cortisol!! Ask For Help or Advice 4
ddjd raising cortisol with t4= terrible headaches, similar to a hangover Ask For Help or Advice 9
haidut Blocking Cortisol May Treat Even Terminal Cancers Scientific Studies 9
N Phosphatidylserine Gives Me Weird Feeling In My Kidney (High Cortisol) Cortisol, Serotonin, Histamine 1
ursidae Environment For High Cortisol Individuals Ask For Help or Advice 3
Jwicks1995 Seroquel/Quetiapine - Cortisol/Anti-Seretonin Cortisol, Serotonin, Histamine 37
F Can Thyroid Supplementation Lower Already Low Cortisol? Cortisol, Serotonin, Histamine 2
Lokzo 5-HTP Increases Cortisol In Healthy Volunteers Scientific Studies 5
C Higher Carb To Protein Ratio Results In Higher Testosterone And Lower Cortisol In Men (1987) Scientific Studies 5
D Is High Cortisol And Reverse T3 Making Me Hypothyroid? Blood Work, Labs 4
Orangeyouglad Why Would I Have Normal/High Blood Cortisol, But Low Saliva Cortisol? Cortisol, Serotonin, Histamine 1
Elize What Can Be Used To Lower Histamine But Not Cortisol Fruit Juice 51
koreus Tearful After Reducing Stress And Cortisol By Removing PUFA Cortisol, Serotonin, Histamine 11
R Too Much Protein. Adrenaline/cortisol? Ask For Help or Advice 2
L Association Between High Serum Total Cortisol Concentrations And Mortality From COVID-19 Scientific Studies 0
C How To Interpret This Cortisol Test? Ask For Help or Advice 3
fever257 Cortisol - Getting It Under Control Ask For Help or Advice 10
bzmazu CORTISOL And COVID-19 Viruses, Parasites, Fungus, Vaccines 2
ddjd Dopamine = Very Male Energy. Cortisol/serotonin = Female Ask For Help or Advice 41
M Coffee And Cortisol Caffeine 1
ddjd Cortisol Itself Lowers Histamine Levels Ask For Help or Advice 12
Hgreen56 Has Someone Positive Experience Lowering Cortisol With Caffeine? Supplements, Pharmaceutical Drugs 4
haidut Stress (cortisol) Can Cause ANY Autoimmune Condition By Disrupting Gut Barrier Scientific Studies 0
A NLR As Marker Of Estrogen And Cortisol Levels Scientific Studies 9
N Low Cortisol At Night Causing Drop In Sugar -- Waking Up Frequently Blood Sugar 12
B Low AM Cortisol And Undetectable Progesterone On HCG Blood Work, Labs 0
haidut Cortisol Drives Triple-negative Breast Cancer, Androgens (DHT) Are Therapeutic Scientific Studies 0
GutFeeling Glucose Causes A Very Strong Blunting If Cortisol Response To Weightlifting, Ameliorate Growth Scientific Studies 4
berk Study: Fructose Is A Cortisol Booster Scientific Studies 38
Amazigh Night Cortisol Is Still High In Spite Of Interventions? Cortisol, Serotonin, Histamine 1
haidut How Chronic Stress (cortisol) Causes Disease Scientific Studies 0
haidut Glucose Is Anabolic For Thymus, Opposes Catabolic Effects Of Cortisol Scientific Studies 2
theDao Combating Elevated Cortisol & Histamine Resulting From Jogging & Sprinting Cortisol, Serotonin, Histamine 55
Peatogenic If Endotoxin Isn't Under Control, Can't Anti Estrogen/cortisol Efforts Actually Increase Them? Supplements, Pharmaceutical Drugs 35
J Since Taking Super Cortisol Support Cortisol, Serotonin, Histamine 0
F Cortisol Resistance / Downregulation Of Cortisol Receptors Cortisol, Serotonin, Histamine 0
Inaut Ray Peat Q&A - Insulin Resistance, Vegans, Low Cortisol, Bone Broth, And Coconut! W/ Jodelle Interviews 14
Mito Cortisol And Antidepressant Effects Of Yoga Articles & Scientific Studies 7
Such_Umami What's The Fewest Amount Of Carbs Before You Start Creating Cortisol? Ask For Help or Advice 6

Similar threads

Top