• Due to excessive bot signups along with nefarious actors we are limiting forum registration. Keep checking back for the register link to appear. Please do not send emails or have someone post to the forum asking for a signup link. Until the current climate changes we do not see a change of this policy. To join the forum you must have a compelling reason. Letting us know what skills/knowledge you will bring to the community along with the intent of your stay here will help in getting you approved.

haidut

Member
Joined
Mar 18, 2013
Messages
18,182
Location
USA / Europe
As many forum users probably know, glucocorticoid treatment is one of the main lines of therapies in cancer. It is considered highly beneficial due to reducing inflammation and swelling/pain in inflamed/cancerous tissue. However, recent studies have shown that immune dysfunction is perhaps the main reason behind the initiation and progression of cancer, and that restoring immune activity may be as simple as blocking estrogen.
Immune Decline (Not Genetics) Causes Cancer And It Can Be Easily Fixed
Reducing Estrogen Synthesis Regenerates Thymus Destroyed By Aging

Considering that glucocorticoid are the most potent agents known for destroying the thymus gland (i.e. thymolytic), and that glucocorticoids are among the most potent inducers of estrogen synthesis, it seems that administering glucocorticoid to cancer patients would be a rather bad idea.
The study below corroborates this idea and suggests that glucocorticoid therapy in cancer could be rather dangerous except in a very small proportion of patients.

Corticosteroid co-treatment induces resistance to chemotherapy in surgical resections, xenografts and established cell lines of pancreatic cancer. - PubMed - NCBI
"...In conclusion, we show by in vitro,ex vivo and in vivo studies that application of DEX renders pancreatic cancer cells resistant to apoptosis and promotes proliferation following cytotoxic therapy. This is in contrast to the effect of GCs in lymphoid cells and may involve cell type specific regulation of survival molecules such as SGK-1 and MKP-1 together with anti-apoptotic molecules such as X-IAP and Bcl-2. Thus, while some properties of GCs may be of benefit, induction of resistance in tumour cells towards cancer therapy may be dangerous for patients. Prospective clinical studies which do not exist until now, are urgently needed."
 

haidut

Member
Thread starter
Joined
Mar 18, 2013
Messages
18,182
Location
USA / Europe

I disagree.
Comparison of the effect of cortisol on aromatase activity and androgen metabolism in two human fibroblast cell lines derived from the same individ... - PubMed - NCBI
Cortisol induces aromatase expression in human placental syncytiotrophoblasts through the cAMP/Sp1 pathway. - PubMed - NCBI
https://joe.bioscientifica.com/downloadpdf/journals/joe/158/3/401.xml
http://press.endocrine.org/doi/abs/10.1210/endo-meetings.2016.TB.1.FRI-069

Btw, the studies you posted do not show corticoids decreasing aromatase. They talk about the GR receptors and show cortisol sometimes antagonizes the ER. That is not the same as inhibiting aromatase. As far as estrogen - if estrogen blocks the GR then it does not induce GR resistance but actually treats it. Agonists induce resistance by downregulating a receptor, so if estrogen inhibits GR then it is an antagonist. RU486 is a GR antagonist and it is used to reverse GR resistance.
Finally, in Cushing syndrome (excess cortisol) about 80% of the male patients have gyno. Gyno is caused by estrogen/prolactin, so the high cortisol in those patients must be increasing estrogen/prolactin somehow, which matches what I mentioned before and the studies I posted.
 
Similar threads
Thread starter Title Forum Replies Date
M Cortisol and histamine Blood Work, Labs 6
T Can lower blood cortisol make you excrete more through the urine? Cortisol, Serotonin, Histamine 0
JamesGatz Can earplugs or sound-resistant rooms have a positive effect on metabolism in certain environments ? Examining the cortisol increase for loud noises Miscellaneous 33
zwez Lutein and Zeaxanthin reduce psychological stress, serum cortisol Scientific Studies 3
C Help with DUTCH results- low estrogen, low progesterone but normal cortisol? Blood Work, Labs 4
J Progesterone dosage for boosting cortisol/T3 utilization Progesterone 8
T Help interpreting Cortisol AM/PM test, and 24 hours urine cortisol test Cortisol, Serotonin, Histamine 0
D Can I Lower My Cortisol Levels With A Natural Substance? Cortisol, Serotonin, Histamine 13
OccamzRazer Low cortisol = difficulty getting out of bed in the morning? Insomnia, Sleep Issues 32
haidut Stress ups cortisol/estrogen/prolactin, drops DHT, causes male infertility and prostate issues Scientific Studies 0
haidut Cortisol causes fatty liver (as well as obesity, diabetes, etc) Scientific Studies 1
haidut Stress (cortisol) causes hair loss Scientific Studies 3
Hans Perfect health trilogy for reducing stress, lowering cortisol and improving health Articles & Scientific Studies 13
E Is 620nmol/l morning cortisol consider to high? Blood Work, Labs 12
Pina High morning cortisol should I avoid pregnenolone before bed? Cortisol, Serotonin, Histamine 13
E Did anyone already tried astressin B for hair loss when you have high blood cortisol? Ask For Help or Advice 0
haidut Blocking cortisol may treat terminal pancreatic cancer Scientific Studies 12
haidut Stress (cortisol) causes pre-term birth by blocking progesterone Scientific Studies 4
haidut DHT / Progesterone / aspirin treat, cortisol ineffective, PUFA promotes prostate cancer Scientific Studies 3
A High-carb diet vs supplements for reducing cortisol Diet 3
haidut Cortisol may drive COVID-19 mortality Scientific Studies 13
haidut Stress (cortisol) as the driver of hyperglycemia in type II diabetes Scientific Studies 0
haidut Sugar (sucrose) lowers stress-induced cortisol Scientific Studies 5
A Cheap and effective anti-cortisol supp/alternative to ashwaghanda Supplements, Pharmaceutical Drugs 28
J Best way to deal with hypoglycemia due to low cortisol? Blood Sugar 1
E Morning blood cortisol 640 nmol/L Cortisol, Serotonin, Histamine 1
Hans How to lower intracellular cortisol Articles & Scientific Studies 15
thingsvarious Adrenal fatigue: Best methods to increase cortisol naturally Cortisol, Serotonin, Histamine 20
F ""Low Serum AM Cortisol The Cause Of My Problems?"" Doubts About Milk 72
N Extremely High Cortisol Ask For Help or Advice 4
S Raising cortisol while on low carb Cortisol, Serotonin, Histamine 4
haidut Heart attack survivors have high stress (cortisol/adrenaline) hypersensitivity, low androgens Scientific Studies 2
haidut Fasting ups estrogen & cortisol, decimates vitamin D, may cause diabetes Scientific Studies 52
haidut Vitamin D prevents cortisol-induced depression and...inflammation Scientific Studies 0
haidut Vitamin D is anti-catabolic / anabolic, protects liver from cortisol injury Scientific Studies 2
ddjd Testosterone agonises 11-beta-HSD-1 i.e. raising cortisol!! Ask For Help or Advice 4
ddjd raising cortisol with t4= terrible headaches, similar to a hangover Ask For Help or Advice 16
haidut Blocking Cortisol May Treat Even Terminal Cancers Scientific Studies 9
N Phosphatidylserine Gives Me Weird Feeling In My Kidney (High Cortisol) Cortisol, Serotonin, Histamine 1
ursidae Environment For High Cortisol Individuals Ask For Help or Advice 4
Jwicks1995 Seroquel/Quetiapine - Cortisol/Anti-Seretonin Cortisol, Serotonin, Histamine 37
F Can Thyroid Supplementation Lower Already Low Cortisol? Cortisol, Serotonin, Histamine 4
Lokzo 5-HTP Increases Cortisol In Healthy Volunteers Scientific Studies 5
C Higher Carb To Protein Ratio Results In Higher Testosterone And Lower Cortisol In Men (1987) Scientific Studies 5
D Is High Cortisol And Reverse T3 Making Me Hypothyroid? Blood Work, Labs 4
Orangeyouglad Why Would I Have Normal/High Blood Cortisol, But Low Saliva Cortisol? Cortisol, Serotonin, Histamine 1
Elize What Can Be Used To Lower Histamine But Not Cortisol Fruit Juice 54
koreus Tearful After Reducing Stress And Cortisol By Removing PUFA Cortisol, Serotonin, Histamine 11
R Too Much Protein. Adrenaline/cortisol? Ask For Help or Advice 2
L Association Between High Serum Total Cortisol Concentrations And Mortality From COVID-19 Scientific Studies 0

Similar threads

Top