ddjd
Member
- Joined
- Jul 13, 2014
- Messages
- 6,722
It is commonly believed that cortisol causes allergies. That’s only part of the picture. The fact is that cortisol itself lowers histamine levels. It is the hormone that stimulates the adrenal release of cortisol that causes histamine release from mast cells. Chronically elevated CRH is associated with stress, as the release of CRH causes cortisol release from the adrenal glands. Under chronic stress, cortisol levels are low as the adrenal glands become exhausted and cannot produce sufficient cortisol. Yet the CRH hormone is likely elevated in chronic stress because the hypothalamus releases CRH via the HPA axis as the body is trying to induce more cortisol to address the stress perceived by the brain. Chronic stress is thereby a major cause of histamine release from mast cells due to the effect of corticotropic releasing hormone CRH