Skullcap, Chinese and American, and Thyme.
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Charlie's Restoration Giveaway #2 (Entire Home EMF Mitigation & Protection Along With Personal Protection) - Click Here To Enter
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Dear Carnivore Dieters, A Muscle Meat Only Diet is Extremely Healing Because it is a Low "vitamin A" Diet. This is Why it Works so Well...
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David PS
Member
Comparative evaluation of flavonoids reveals the superiority and promising inhibition activity of silibinin against SARS-CoV-2 - PubMed
Flavonoids are phenolic compounds naturally found in plants and commonly consumed in diets. Herein, flavonoids were sequentially evaluated by a comparative in silico study associated with systematic literature search. This was followed by an in vitro study and enzyme inhibition assays against...
pubmed.ncbi.nlm.nih.gov
Z
Zsazsa
Guest
Efficacy and Safety of Aspirin, Promethazine, and Micronutrients for Rapid Clinical Recovery in Mild to Moderate COVID-19 Patients: A Randomized Controlled Clinical Trial
Introduction In the present study, the combination of two tablets, one with Aspirin and Promethazine and the other with vitamin D3, C, and B3 along with zinc and selenium supplementation was proposed as an intervention (APMV2020). The ingredients in the formulation represent a precise, tailored...
www.cureus.com
Grapelander
Member
Can biowarfare agents be defeated with light?
Germicidal UV (UVC) is exceptionally active in destroying a wide range of viruses and microbial cells, and recent data suggests that UVC has high selectivity over host mammalian cells and tissues.The combination of photosensitizing dyes such as porphyrins or phenothiaziniums and red light is called photodynamic therapy (PDT) or photoinactivation, and this approach cannot only kill bacteria, spores, and fungi, but also inactivate viruses and toxins. Many reports have highlighted the ability of PDT to treat infections and stimulate the host immune system.
Sunlight Kills Coronavirus – US Dept Of Homeland Security Study
Lab experiments showed that the coronavirus does not survive long in high temperatures and high humidity, and is quickly destroyed by sunlight, providing evidence from controlled tests.Makes you wonder why are they testing the sewage?
Grapelander
Member
Promethazine is great stuff for nausea. Sounds like a Greek hero also.
David PS
Member
Hospital Study Shows that Covid-19 Can be Prevented with Hydrogen Peroxide
This article may be...
Grapelander
Member
Natural Immunity & Viral Infections - Ray Peat - Townsend Letter Aug/Sep 1988 <Page 358 - 359>
There is a long history of anesthetic substances being used to treat viral diseases. Abrams, in a 1910 textbook, described the use of chloroform to cure a viral disease in a horse. Camphor, besides being used as a local anesthetic and a heart stimulant, has been used to treat influenza and other systemic diseases, and is one of the oldest topical treatments for herpes sores. More recently, a veterinarian reported curing an virus disease in a dog with an anesthetic dose of ether.
Adamantane, which can be extracted from petroleum, is a close structural analog of camphor, and smells like camphor. With the addition of a nitrogen atom, it is water soluble, and is an effective anti-viral agent, and is also widely used in treating Parkinson's disease (its function is cholinolytic), and more recently is being used in preventing withdrawal symptoms in cocaine addiction.' It is not metabolized, and does not present the genetic risk that has recently been recognized for other antiviral agents which disrupt viral DNA.
The fact that the body is well supplied with substances which -at a slightly higher concentration - are anesthetics. and which are depleted by the stresses which predispose to viral infections, suggests that they may normally have a camphor-like anti-viral activity. Some of these substances, the anesthetic steroids, have been found to prevent some viral infections, and they also have a wide range of anti-toxic effects. Pregnenolone, progesterone, DHEA, and pregnanediol are all good candidates as antiviral drugs, but etiocholanolone - which also produces fever is the most interesting of the group.
It is well-known that stress, acting mainly through the glucocorticoid hormones, damages immunity by destroying thymus cells. The anesthetic steroids, especially progesterone, normally reduce the need for secretion of cortisol, but also act as a protective buffer against the damaging effects of cortisol. Although a physiologically balanced amount of cortisol induces enzymes of detoxification, for example in the intestine, an unopposed excess causes destruction of these enzymes, eliminating much of the intestine's barrier function, and leading to allergies. This action of cortisol against the thymus and against the bowel's detoxifying enzymes very likely counts for the common association of allergies with virus infections. Since cortisol has a destabilizing, pro-convulsant effect on the nervous system, there are likely to be psychological symptoms - anything from compulsive behavior to depression or seizures - associated with the other chronic conditions.
In the last century, it was observed that digitoxin (a natural steroid derivative) lowered the fever caused by enteritis. This is probably another example of a catatoxic function, a protective function common to many steroids, and probably worked by way of stabilizing the detoxifying enzymes and preventing the absorption of endotoxin. Endotoxin is known to destabilize and inactivate the bowel's detoxifying enzymes, just as an overdose of cortisol does.
Adequate energy, for example as available glucose is protective against cortisol-induced catabolism. White blood cells can protect themselves by metabolizing cortisol in the presence of sufficient glucose.
Some of the consequences of stress are not catabolic. When the detoxifying enzymes have been lost, then bowel toxins block other basic enzyme systems, leading for example to slowed protein turnover and decreased activity of superoxide dismutase. The consequent increase of lipid peroxidation will decrease steroid synthesis. Stress also leads to the production of intracellular toxins, including ammonia and carbon monoxide, which tend to perpetuate the blocked state.
While W.F. Koch was interested in the body's own oxidative free radical system of destroying toxins and pathogens, he studied several natural quinones found in medicinal plants. Recent work has found that phototoxins extracted from plants can kill mouse-cytomegalovirus without damaging the mouse cells.
The basic approach to controlling viral diseases should be to support natural immunity, by maintaining energy production at a high level by unblocking and stabilizing the detoxifying enzymes, including mono-oxygenases, proteolytic enzymes, SOD, and nucleases, and by avoiding prolonged catabolic states.
Many natural substances are available which promote these ends, without risk.
While this approach supports the known mechanism of the immune system, including protection of thymus cells and activation of the various white cell mechanisms of attack, it has the novel feature of altering cells physically to retard viral assembly, increasing their exposure to nucleases, proteases. and mono-oxygenases; that is it mobilizes immune processes in cells which are not part of the immune system. By eliminating stress-induced susceptibility, it systematically shifts the balance toward normal functioning, and away from parasitic diversion of the organism's resources.
There is a long history of anesthetic substances being used to treat viral diseases. Abrams, in a 1910 textbook, described the use of chloroform to cure a viral disease in a horse. Camphor, besides being used as a local anesthetic and a heart stimulant, has been used to treat influenza and other systemic diseases, and is one of the oldest topical treatments for herpes sores. More recently, a veterinarian reported curing an virus disease in a dog with an anesthetic dose of ether.
Adamantane, which can be extracted from petroleum, is a close structural analog of camphor, and smells like camphor. With the addition of a nitrogen atom, it is water soluble, and is an effective anti-viral agent, and is also widely used in treating Parkinson's disease (its function is cholinolytic), and more recently is being used in preventing withdrawal symptoms in cocaine addiction.' It is not metabolized, and does not present the genetic risk that has recently been recognized for other antiviral agents which disrupt viral DNA.
The fact that the body is well supplied with substances which -at a slightly higher concentration - are anesthetics. and which are depleted by the stresses which predispose to viral infections, suggests that they may normally have a camphor-like anti-viral activity. Some of these substances, the anesthetic steroids, have been found to prevent some viral infections, and they also have a wide range of anti-toxic effects. Pregnenolone, progesterone, DHEA, and pregnanediol are all good candidates as antiviral drugs, but etiocholanolone - which also produces fever is the most interesting of the group.
It is well-known that stress, acting mainly through the glucocorticoid hormones, damages immunity by destroying thymus cells. The anesthetic steroids, especially progesterone, normally reduce the need for secretion of cortisol, but also act as a protective buffer against the damaging effects of cortisol. Although a physiologically balanced amount of cortisol induces enzymes of detoxification, for example in the intestine, an unopposed excess causes destruction of these enzymes, eliminating much of the intestine's barrier function, and leading to allergies. This action of cortisol against the thymus and against the bowel's detoxifying enzymes very likely counts for the common association of allergies with virus infections. Since cortisol has a destabilizing, pro-convulsant effect on the nervous system, there are likely to be psychological symptoms - anything from compulsive behavior to depression or seizures - associated with the other chronic conditions.
In the last century, it was observed that digitoxin (a natural steroid derivative) lowered the fever caused by enteritis. This is probably another example of a catatoxic function, a protective function common to many steroids, and probably worked by way of stabilizing the detoxifying enzymes and preventing the absorption of endotoxin. Endotoxin is known to destabilize and inactivate the bowel's detoxifying enzymes, just as an overdose of cortisol does.
Adequate energy, for example as available glucose is protective against cortisol-induced catabolism. White blood cells can protect themselves by metabolizing cortisol in the presence of sufficient glucose.
Some of the consequences of stress are not catabolic. When the detoxifying enzymes have been lost, then bowel toxins block other basic enzyme systems, leading for example to slowed protein turnover and decreased activity of superoxide dismutase. The consequent increase of lipid peroxidation will decrease steroid synthesis. Stress also leads to the production of intracellular toxins, including ammonia and carbon monoxide, which tend to perpetuate the blocked state.
While W.F. Koch was interested in the body's own oxidative free radical system of destroying toxins and pathogens, he studied several natural quinones found in medicinal plants. Recent work has found that phototoxins extracted from plants can kill mouse-cytomegalovirus without damaging the mouse cells.
The basic approach to controlling viral diseases should be to support natural immunity, by maintaining energy production at a high level by unblocking and stabilizing the detoxifying enzymes, including mono-oxygenases, proteolytic enzymes, SOD, and nucleases, and by avoiding prolonged catabolic states.
Many natural substances are available which promote these ends, without risk.
While this approach supports the known mechanism of the immune system, including protection of thymus cells and activation of the various white cell mechanisms of attack, it has the novel feature of altering cells physically to retard viral assembly, increasing their exposure to nucleases, proteases. and mono-oxygenases; that is it mobilizes immune processes in cells which are not part of the immune system. By eliminating stress-induced susceptibility, it systematically shifts the balance toward normal functioning, and away from parasitic diversion of the organism's resources.
Z
Zsazsa
Guest
Very interesting ( @Rinse & rePeat is a frequent nettle user)
Personally I found that histamine-lowering agents were the best intervention against Omicron (after infection).
Submitted preprint here
Carbohydrate-Binding Protein from Stinging Nettle as Fusion Inhibitor for SARS-CoV-2 Variants of Concern
Carbohydrate-Binding Protein from Stinging Nettle as Fusion Inhibitor for SARS-CoV-2 Variants of Concern
Urtica dioica agglutinin (UDA) is a carbohydrate-binding small monomeric protein isolated from stinging nettle rhizomes. It inhibits replication of a broad range of viruses, including coronaviruses, in multiple cell types, with appealing selectivity. In this work, we investigated the potential...www.biorxiv.org
Abstract
Urtica dioica agglutinin (UDA) is a carbohydrate-binding small monomeric protein isolated from stinging nettle rhizomes. It inhibits replication of a broad range of viruses, including coronaviruses, in multiple cell types, with appealing selectivity. In this work, we investigated the potential of UDA as a broad-spectrum antiviral agent against SARS-CoV-2. UDA potently blocks entry of pseudotyped SARS-CoV-2 in A549.ACE2+-TMPRSS2 cells, with IC50 values ranging from 0.32 to 1.22 µM. Furthermore, UDA prevents viral replication of the early Wuhan-Hu-1 strain in Vero E6 cells (IC50 = 225 nM), but also the replication of SARS-CoV-2 variants of concern, including Alpha, Beta and Gamma (IC50 ranging from 115 to 171 nM). In addition, UDA exerts antiviral activity against the latest circulating Delta and Omicron variant in U87.ACE2+ cells (IC50 values are 1.6 and 0.9 µM, respectively). Importantly, when tested in Air-Liquid Interface (ALI) primary lung epithelial cell cultures, UDA preserves antiviral activity against SARS-CoV-2 (20A.EU2 variant) in the nanomolar range. Surface plasmon resonance (SPR) studies demonstrated a concentration-dependent binding of UDA to the viral spike protein of SARS-CoV-2, suggesting interference of UDA with cell attachment or subsequent virus entry. Moreover, in additional mechanistic studies with cell-cell fusion assays, UDA inhibited SARS-CoV-2 spike protein-mediated membrane fusion. Finally, pseudotyped SARS-CoV-2 mutants with N-glycosylation deletions in the S2 subunit of the spike protein remained sensitive to the antiviral activity of UDA. In conclusion, our data establish UDA as a potent and broad-spectrum fusion inhibitor for SARS-CoV-2.
Some of the previous publications:
2022
Heliyon
Nutritional and pharmacological importance of stinging nettle (Urtica dioica L.): A review
Stinging nettle (Urtica dioica L.) is a wild herbaceous perennial blooming plant that is commonly known as stinging nettle. It’s a common, multi-purpo…www.sciencedirect.com
Volume 8, Issue 6, June 2022, e09717
Journal home page for Heliyon
Review article
Nutritional and pharmacological importance of stinging nettle (Urtica dioica L.): A review
Abstract
Stinging nettle (Urtica dioica L.) is a wild herbaceous perennial blooming plant that is commonly known as stinging nettle. It’s a common, multi-purpose crop that’s sometimes overlooked. Europe, Asia, North Africa, and North America are all home to stinging nettle. It is a plant that’s edible and has nutritional and medicinal properties. Young leaves can be used to make curries, herb soups, and sour soups. The root of the stinging nettle is used to treat mictional difficulties associated with benign prostatic hyperplasia, while the leaves are used to treat arthritis, rheumatism, and allergic rhinitis. Its leaves are abundant in fiber, minerals, vitamins, and antioxidant compounds like polyphenols and carotenoids, as well as antioxidant compounds like polyphenols and carotenoids. Stinging nettle has antiproliferative, anti-inflammatory, antioxidant, analgesic, anti-infectious, hypotensive, and antiulcer characteristics, as well as the ability to prevent cardiovascular disease, in all parts of the plant (leaves, stems, roots, and seeds). Stinging nettle improves fish reproductive performance, making it a cost-effective aquaculture plant. Fertilizer and insecticides can be made from the plants. This review examines the nutritional and pharmacological aspects of stinging nettle, as well as its possible health advantages. Scientists, farmers, and academicians interested in stinging nettle collecting, cultivation, research, and development would find this review useful.
2021
2011
2011
2005
Journal of Biological Chemistry
Glycobiology and Extracellular Matrices
Carbohydrate-binding Agents Cause Deletions of Highly Conserved Glycosylation Sites in HIV GP120: A NEW THERAPEUTIC CONCEPT TO HIT THE ACHILLES HEEL OF HIV
Mannose-binding proteins derived from several plants (i.e. Hippeastrum hybrid and Galanthus nivalis agglutinin) or prokaryotes (i.e. cyanovirin-N) inh…
Carbohydrate-binding Agents Cause Deletions of Highly Conserved Glycosylation Sites in HIV GP120: A NEW THERAPEUTIC CONCEPT TO HIT THE ACHILLES HEEL OF HIV
Mannose-binding proteins derived from several plants (i.e. Hippeastrum hybrid and Galanthus nivalis agglutinin) or prokaryotes (i.e. cyanovirin-N) inhibit human immunodeficiency virus (HIV) replication and select for drug-resistant viruses that show profound deletion of N-glycosylation sites in the GP120 envelope (Balzarini, J., Van Laethem, K., Hatse, S., Vermeire, K., De Clercq, E., Peumans, W., Van Damme, E., Vandamme, A.-M., Bolmstedt, A., and Schols, D. (2004) J. Virol. 78, 10617-10627; Balzarini, J., Van Laethem, K., Hatse, S., Froeyen, M., Van Damme, E., Bolmstedt, A., Peumans, W., De Clercq, E., and Schols, D. (2005) Mol. Pharmacol. 67, 1556-1565). Here we demonstrated that the N-acetylglucosamine-binding protein from Urtica dioica (UDA) prevents HIV entry and eventually selects for viruses in which conserved N-glycosylation sites in GP120 were deleted. In contrast to the mannose-binding proteins, which have a 50-100-fold decreased antiviral activity against the UDA-exposed mutant viruses, UDA has decreased anti-HIV activity to a very limited extent, even against those mutant virus strains that lack at least 9 of 22 (∼40%) glycosylation sites in their GP120 envelope. Therefore, UDA represents the prototype of a new conceptual class of carbohydrate-binding agents with an unusually specific and targeted drug resistance profile. It forces HIV to escape drug pressure by deleting the indispensable glycans on its GP120, thereby obligatorily exposing previously hidden immunogenic epitopes on its envelope.
David PS
Member
Thanks for the study. It is the root (rhizome) of the nettle plant and not the leaves. Health shops sell both separately.
Urtica dioica agglutinin. A superantigenic lectin from stinging nettle rhizome - PubMed
Urtica dioica agglutinin (UDA) is an unusual plant lectin that differs from all other known plant lectins with respect to its molecular structure and its extremely low specific agglutination activity. We recently reported that this small lectin (8.5 kDa) is a T cell mitogen distinguishable from...
pubmed.ncbi.nlm.nih.gov
The root has high contents of glycine, cysteine and tryptophan.
An unusual lectin from stinging nettle (Urtica dioica) rhizomes
An unusual lectin has been isolated from stinging nettle (Urtica dioica L.) rhizomes. It is a small (8.5 kDa) monomeric protein with high contents of …
Z
Zsazsa
Guest
Yes, I forgot to mention that the tea made from leaves doesn't cut for it, although its anti-histaminic effect might be helpful after infection. I tried green tea for its high quercetin content, but the tea is probably too immunostimulant and made symptoms worse.Thanks for the study. It is the root (rhizome) of the nettle plant and not the leaves. Health shops sell both separately.
Urtica dioica agglutinin. A superantigenic lectin from stinging nettle rhizome - PubMed
Urtica dioica agglutinin (UDA) is an unusual plant lectin that differs from all other known plant lectins with respect to its molecular structure and its extremely low specific agglutination activity. We recently reported that this small lectin (8.5 kDa) is a T cell mitogen distinguishable from...
The root has high contents of glycine, cysteine and tryptophan.
An unusual lectin from stinging nettle (Urtica dioica) rhizomes
An unusual lectin has been isolated from stinging nettle (Urtica dioica L.) rhizomes. It is a small (8.5 kDa) monomeric protein with high contents of …
David PS
Member
P
Peatness
Guest
Debi Evans Blog: 2 August 2022
Debi Evans' weekly blog of startling events in healthcare.
www.ukcolumn.org
From the article
AstraZeneca, on the other hand, would prefer you didn’t get Covid-19 at all. ‘Fortuitously’ for all of us, they have a prophylactic injection lined up. Behold AstraZeneca's Evusheld, said to stop the ‘virus’ mutating. It is an investigational medicine, which means it is still being studied. There is limited information known about the safety and effectiveness of using Evusheld for pre-exposure prevention of Covid-19 (prophylaxis). It is allowed to be used in adolescents of 12 years and older, and adults.
Evusheld will also be administered to people who have suffered a serious adverse reaction to a Covid-19 vaccine or one of its ingredients.
It has been authorised by the FDA under an Emergency Use Authorisation (EMA) and by the MHRA under its equivalent, although—considering we are no longer in a state of emergency—I am failing to understand the logic behind this. I would expect the autumnal refrains as to who must be given these injections to include the most vulnerable in society, those who are immunocompromised and those who have cancer, to ‘keep them safe’.
Evusheld is a monoclonal antibody containing Tixagevimab and Cilgavimab. It will be given in a course of two consecutive injections. Those accepting it will be told that due to the existence of different variants, they will need reinjecting every six months.
It's great to know that AstraZeneca is enjoying huge sales growth of more than 20% this year and that doctors are highly eager to prescribe Evusheld and make it available to the great unjabbed and those deemed vulnerable.
So, given Covid cases are dwindling, why all the fuss? Or are we supposed to be expecting something else? I suspect we have more fear and propaganda to come.
Z
Zsazsa
Guest
Acetylsalicylic acid and Salicylic acid inhibit SARS-CoV-2 replication in precision-cut lung slices
Aspirin, with its active compound acetylsalicylic acid (ASA), shows antiviral activity against rhino- and influenza viruses and at high concentrations. We sought to investigate whether ASA and its metabolite salicylic acid (SA) inhibit SARS-CoV-2 since it might use similar pathways to influenza...
Vitamin B12 attenuates leukocyte inflammatory signature in COVID-19 via methyl-dependent changes in epigenetic marks
COVID-19 induces chromatin remodeling in host immune cells, and it had previously been shown that vitamin B12 downregulates some inflammatory genes via methyl-dependent epigenetic mechanisms. In this work, whole blood cultures from moderate or severe COVID-19 patients were used to assess the...
Nice @Zsazsa. Thank you.Acetylsalicylic acid and Salicylic acid inhibit SARS-CoV-2 replication in precision-cut lung slices
Aspirin, with its active compound acetylsalicylic acid (ASA), shows antiviral activity against rhino- and influenza viruses and at high concentrations. We sought to investigate whether ASA and its metabolite salicylic acid (SA) inhibit SARS-CoV-2 since it might use similar pathways to influenza...
Vitamin B12 attenuates leukocyte inflammatory signature in COVID-19 via methyl-dependent changes in epigenetic marks
COVID-19 induces chromatin remodeling in host immune cells, and it had previously been shown that vitamin B12 downregulates some inflammatory genes via methyl-dependent epigenetic mechanisms. In this work, whole blood cultures from moderate or severe COVID-19 patients were used to assess the...
EMF Mitigation - Flush Niacin - Big 5 Minerals
