Corona Virus How To Treat

B

Braveheart

Guest
If it is really that important to you...do it yourself...copy pertinent info to Notepad...won't take that long and you'll have the info you most value. Then when new post appears w info you like you just copy to your notes, taking only a minute... Often some lazy forum people want someone to do the work for them.
 

Motif

Member
Joined
Nov 24, 2017
Messages
2,757
If it is really that important to you...do it yourself...copy pertinent info to Notepad...won't take that long and you'll have the info you most value. Then when new post appears w info you like you just copy to your notes, taking only a minute... Often some lazy forum people want someone to do the work for them.
Maybe somebody is just more into it and can easily write down what would be a good selection of stuff and that is really up to date.

If not , then not ??‍♂️



Anybody knows what Chris masterjohn recommends meanwhile ? I don’t want to pack money for it ??‍♂️
 

Lollipop2

Member
Joined
Nov 18, 2019
Messages
5,267

David PS

Member
Joined
Jan 5, 2016
Messages
14,675
Location
Dark side of the moon

Gramicidin S and Melittin - Potential anti-viral therapeutic peptides to treat SARS-CoV-2 infection​

The COVID19 pandemic has resulted in multipronged approaches for treatment of the disease. Since de novo discovery of drugs is time consuming, repurposing of molecules is now considered as one of the alternative strategies to treat COVID19. Antibacterial peptides are being recognized as attractive candidates for repurposing to treat viral infections. In this study, we describe the anti-SARS-CoV-2 activity of gramicidin S and melittin peptides obtained from Bacillus brevis and bee venom respectively. Our in vitro antiviral assay results showed significant decrease in the viral load compared to the untreated group with no/very less cytotoxicity. The EC50 values for gramicidin S and melittin are calculated as 1.571μg and 0.656μg respectively. Both the peptides treated to the SARS-CoV-2 infected Vero cells showed viral clearance from 12 hours onwards with a maximal clearance after 24 hours post infection. Based on proteome analysis it was found that more than 250 proteins were found to be differentially regulated in the gramicidin S and melittin treated SARS-CoV-2 infected Vero cells against control SARS-CoV-2 infected Vero cells after 24 and 48 hours post infection. The identified proteins were found to be associated in the metabolic and mRNA processing of the Vero cells post-treatment and infection. Both these peptides could be attractive candidates for repurposing to treat SARS-CoV-2 infection.

 

David PS

Member
Joined
Jan 5, 2016
Messages
14,675
Location
Dark side of the moon

Lollipop2

Member
Joined
Nov 18, 2019
Messages
5,267

Gramicidin S and Melittin - Potential anti-viral therapeutic peptides to treat SARS-CoV-2 infection​

The COVID19 pandemic has resulted in multipronged approaches for treatment of the disease. Since de novo discovery of drugs is time consuming, repurposing of molecules is now considered as one of the alternative strategies to treat COVID19. Antibacterial peptides are being recognized as attractive candidates for repurposing to treat viral infections. In this study, we describe the anti-SARS-CoV-2 activity of gramicidin S and melittin peptides obtained from Bacillus brevis and bee venom respectively. Our in vitro antiviral assay results showed significant decrease in the viral load compared to the untreated group with no/very less cytotoxicity. The EC50 values for gramicidin S and melittin are calculated as 1.571μg and 0.656μg respectively. Both the peptides treated to the SARS-CoV-2 infected Vero cells showed viral clearance from 12 hours onwards with a maximal clearance after 24 hours post infection. Based on proteome analysis it was found that more than 250 proteins were found to be differentially regulated in the gramicidin S and melittin treated SARS-CoV-2 infected Vero cells against control SARS-CoV-2 infected Vero cells after 24 and 48 hours post infection. The identified proteins were found to be associated in the metabolic and mRNA processing of the Vero cells post-treatment and infection. Both these peptides could be attractive candidates for repurposing to treat SARS-CoV-2 infection.

Wonder if these are available to public?
 

David PS

Member
Joined
Jan 5, 2016
Messages
14,675
Location
Dark side of the moon

This seasonality could contribute importantly to the transmission of SARS-CoV-2, since low humidity conditions have been shown to reduce the size of aerosols, and thereby increase airborne transmission of seasonal viruses such as influenza. “This link warrants an emphasis on ‘air hygiene’ through improved indoor ventilation as aerosols are capable to persist suspended for longer times,” says Rodó, and highlights the need to include meteorological parameters in the evaluation and planning of control measures.
 

Lollipop2

Member
Joined
Nov 18, 2019
Messages
5,267
EMF Mitigation - Flush Niacin - Big 5 Minerals

Similar threads

Back
Top Bottom