Amazoniac
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Ecstatic hamsters,
Considering that it’s common to find that there’s copper accumulation in organs of people with compromised metabolism™, here’s a study in which they identified that there’s an interplay between copper and iron, and both are manipulated during infections: their accumulation doesn’t occur accidentally.
Host-Imposed Copper Poisoning Impacts Fungal Micronutrient Acquisition during Systemic Candida albicans Infections
“The case for nutritional immunity is well documented for iron, and bacterial and fungal pathogens including C. albicans require effective iron acquisition mechanisms for full virulence [56,58]. Here we demonstrate another layer of complexity governing the pathogen-host tug of war—the regulation of copper homeostasis.”
“Our data clearly indicate that disseminated fungal infections affect copper metabolism in organs that promptly clear the infection (the liver and spleen), as well as organs that become colonized (the kidney). These changes coincide with previously described [12] infection-associated perturbations in iron metabolism in these organs. Unsurprisingly, the local changes in copper levels are sensed by C. albicans. Similarly to iron acquisition [12, 56, 58], intact copper acquisition pathways (Fig 3D) are required for full C. albicans virulence.”
The study has plenty of references to investigate the issue of copper accumulation in tissues, in case someone's interested.
By the way, nutritional immunology is one of the fields that probably has the most bull**** per paragraph that you can find, so it demands patience to screen what's worth..
Considering that it’s common to find that there’s copper accumulation in organs of people with compromised metabolism™, here’s a study in which they identified that there’s an interplay between copper and iron, and both are manipulated during infections: their accumulation doesn’t occur accidentally.
Host-Imposed Copper Poisoning Impacts Fungal Micronutrient Acquisition during Systemic Candida albicans Infections
“The case for nutritional immunity is well documented for iron, and bacterial and fungal pathogens including C. albicans require effective iron acquisition mechanisms for full virulence [56,58]. Here we demonstrate another layer of complexity governing the pathogen-host tug of war—the regulation of copper homeostasis.”
“Our data clearly indicate that disseminated fungal infections affect copper metabolism in organs that promptly clear the infection (the liver and spleen), as well as organs that become colonized (the kidney). These changes coincide with previously described [12] infection-associated perturbations in iron metabolism in these organs. Unsurprisingly, the local changes in copper levels are sensed by C. albicans. Similarly to iron acquisition [12, 56, 58], intact copper acquisition pathways (Fig 3D) are required for full C. albicans virulence.”
The study has plenty of references to investigate the issue of copper accumulation in tissues, in case someone's interested.
By the way, nutritional immunology is one of the fields that probably has the most bull**** per paragraph that you can find, so it demands patience to screen what's worth..
