When I take high dose thyroid I have to eat at night - sometimes every 2 hours. If your adrenals can't handle that much NDT (that's quite a lot of T3, more than a normal thyroid makes), then you can't keep your blood sugar stable. At least stop taking any NDT after 4 PM and see how you do. Take your blood sugar (you say you are insulin resistant). Take your temps regularly. That will help you figure out what is going on.