Comprehensive investigations revealed consistent pathophysiological alterations after vaccination with COVID-19 vaccines

Jam

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More and more mainstream scientific studies are starting to uncover the damaging effects of these toxic injections. This one is very recent, and published just a few days ago in Nature.

Published: 26 October 2021

Abstract​

Large-scale COVID-19 vaccinations are currently underway in many countries in response to the COVID-19 pandemic. Here, we report, besides generation of neutralizing antibodies, consistent alterations in hemoglobin A1c, serum sodium and potassium levels, coagulation profiles, and renal functions in healthy volunteers after vaccination with an inactivated SARS-CoV-2 vaccine. Similar changes had also been reported in COVID-19 patients, suggesting that vaccination mimicked an infection. Single-cell mRNA sequencing (scRNA-seq) of peripheral blood mononuclear cells (PBMCs) before and 28 days after the first inoculation also revealed consistent alterations in gene expression of many different immune cell types. Reduction of CD8+ T cells and increase in classic monocyte contents were exemplary. Moreover, scRNA-seq revealed increased NF-κB signaling and reduced type I interferon responses, which were confirmed by biological assays and also had been reported to occur after SARS-CoV-2 infection with aggravating symptoms. Altogether, our study recommends additional caution when vaccinating people with pre-existing clinical conditions, including diabetes, electrolyte imbalances, renal dysfunction, and coagulation disorders.
 
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Jam

Jam

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➡️ 1) In this table, extracted from the paper, an analysis of the specific differential gene expression of the subtype and of the overrepresentation of the set of genes describing common gene expression changes between different types of immune cells, ?after vaccination.?Image
2) ➡️ Among all the voices it emerges predominantly (I would say ? VERY worrying) Tumor necrosis factor Alpha (known as ?TNFα, Tumor necrosis factor) which is a cytokine involved in systemic inflammation and is a member of a group of cytokines that stimulate the acute phase
3) reaction.

? It is mainly produced by ?macrophages, although it can be produced by CD4 + T lymphocytes, ?NK cells, ?neutrophils, ?mastocytes, ?eosinophils and ?neurons!

➡️The main role of TNF is 5) in the regulation of immune system cells.
➡️ 4) TNF, being an endogenous pyrogen, is capable of inducing fever, cell apoptosis, inflammation.

? Defects in TNF production are implicated in the etiology of ?Alzheimer's disease, ?6) cancer, ? major depression and ? chronic inflammatory bowel disease!
5) ?TNF can be produced ectopically in case of malignant ?tumor and in parallel with parathyroid hormone it is associated with secondary hypercalcemia! ?

Comprehensive investigations revealed consistent pathophysiological alterations after vaccination with COVID-19 vaccines - Cell DiscoveryComprehensive investigations revealed consistent pathophysiological alterations after vaccination with COVID-19 vaccines - Cell Discovery
@mentions
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➡️1) In this paper these extracts are very significant.?

..."Following SC2 infections, many people have developed varying degrees of respiratory syndromes and some with gastrointestinal conditions. It was reported that blood clotting disorders, vascularity problems,
2) electrolyte imbalances, kidney disorders, metabolic disorders, etc. were major clinical complications with C19 "...

... "The way vaccination would mimic an infection has been analyzed"...

... "To study the detailed changes in gene expression induced by
3) vaccination, we merged individual samples in pseudo-bulk samples and used paired sample tests to identify differentially expressed genes (DEGs). Significantly upregulated genes were involved in TNFα signaling. via NF-κB, inflammatory responses and cytokine-receptor
4) cytokine interaction, IL6-JAK STAT3 signaling, coagulation, hypoxia, which had been reported for C19, while cell cycle related pathways were downregulated. These results supported the idea that vaccination mimicked an infection "...

..."Furthermore, high blood
5) glucose / glycolysis levels have been shown to promote the replication of SARS-CoV-2 in human monocytes through the production of reactive mitochondrial oxygen species and the activation of HIF1A 20, thus presenting a disadvantageous feature"...
6) ?I then deepened, with one of my studies, the completely non-standard value, highlighted in the table of the paper; TNF Alpha signal via NF KB.? ️

➡️Tumor necrosis factor α (usually abbreviated as TNFα, from the English Tumor necrosis factor) is a cytokine involved in
7) systemic inflammation and is a member of a group of cytokines that stimulate the acute phase reaction.

➡️NF-κB ("nuclear factor kappa-light-chain-enhancer of active B cells") is a protein complex that functions as a transcription factor.

➡️NF-κB can be found in all cell
8) types and is involved in all cell reactions to stimuli, such as stress, cytokines, free radicals, ultraviolet irradiation and ?attack from bacterial antigens or viruses.

?NF-κB plays a key role in regulating the immune response to infections and its dysfunctions
9) have been linked to cancer (such as multiple myeloma), inflammatory processes, autoimmune diseases, septic shock, viral infections and diseases of the immune system.

(END).
 

JohnHafterson

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@bidoliNicola is definitely a good follow on Twitter - the interferon signaling is really interesting - complex sometimes paradoxical in terms of the what/where/when/how of IFN A/B/Gamma during CV19/etc in a few papers I've read.
 

GTW

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Conclusion that caution should be observed in vaccinating people with conditions... which are some of those same conditions predisposing to more serious Rona pathology, hospitalization and death.
 

aliml

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Diet And Lifestyle To Inhibit TNF

Foods To Inhibit TNF


-- Sardines
-- Cinnamon
-- Nutritional Yeast
-- Mushrooms
-- Stevia
-- Honey
-- Chocolate / Coffee
-- Trehalose
-- Garlic
-- Fish Oil
-- Dates
-- Blueberries / Berries
-- Sulforaphane / Broccoli Sprouts / Cruciferous Veggies
-- Soy
-- Betalain / Beets
-- Kamut
-- Coriander
-- Tamarind
-- Slippery Elm
-- Dandelion

Hormones

-- Cortisol
-- MSH
-- ACTH
-- Oxytocin
-- Adiponectin
-- Melatonin
-- Vitamin D3
-- Pregnenolone
-- Progesterone
-- Estrogen
-- DHEA
-- Ghrelin

Neurotransmitters

-- Serotonin
-- Acetylcholine

Top Supplements To Inhibit TNF

-- Inositol
-- Boswellia
-- Nicotinamide
-- EGCG
-- Hydroxytyrosol
-- Licorice
-- Luteolin
-- Andrographolide
-- Fisetin
-- Resveratrol

Other Supplements To Inhibit TNF

-- Bile
-- Lactoferrin
-- Glycine
-- Chromium
-- Sialic Acid
-- Arginine
-- Bromelain
-- Berberine
-- Apple polyphenols
-- Silymarin
-- Honokiol
-- Chinese Skullcap / Baicalin
-- Ginkgo
-- Hespderidin
-- Carnosine
-- Phytosterols
-- Tart Cherry
-- Astaxanthin
-- Astragalus
-- Probiotics / B. Coagulans
-- Cat’s claw
-- Artemisinin
-- Carnitine
-- Genistein
-- Amla / Indian Gooseberry
-- CoQ10
-- Magnolol
-- Echinacea
-- Chaga/Betulin
-- Bitter melon
-- Mastic gum
-- Oxymatrine
-- Red clover
-- Glucosamine
-- Quercetin
-- Rutin
-- Myricetin
-- Ashwagandha
-- Chrysin
-- Mannose
-- Forskolin
-- Molecular Hydrogen
-- Histidine
-- Antler velvet
-- Emodin
-- Danshen

Drugs That Inhibit TNF

-- Cannabis / THC / Marijuana
-- Low Dose Naltrexone
-- Metformin
-- Red Yeast Rice / Statins
-- Magic mushrooms
-- LSD
-- Ayahuasca
-- Mescaline
-- Cocaine
-- Allegra / Fexofenadine
-- Mizolastine
-- Bupropion
-- Rapamycin
-- Thalidomide

 
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Jam

Jam

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MartinaSisters


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Oct 31 , 19 tweets, 7 min read
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TRULY this paper in Nature makes it clear that the damage observed with SARS-CoV-2 is the same NOW in vaccinated people.

They don't even hide that THESE vaccines are a chestnut.

Please MAKE other vaccines !! ??

Thank you @BidoliNicola for keeping trying? nature.com/articles/s4142…
All this annoys me a lot, but how can we continue to defend vaccines that mimic the damage of Spike from a virus that may not even be among us anymore?

Stop all this NOW, please stop creating more variants and damage.

In Pif there is also lymphocyte apoptosis!
Pif's FCoVs are immunosuppressive and FCoV-infected cells release substances that cause lymphocyte apoptosis.

The SAME as the lymphopenias observed in Covid19 and after vaccination? ?

That substance they release is TNF-α. Already in 2007 it was studied by Takano et al!
In this Pif study, it is suggested that immunity against Pif progression is linked to an imbalance in the TNF-α and IFN-gamma response that favors the disease. And the destruction of the tissue is due to enzymes released by leukocytes or to the cellular toxicity itself!
They also detected the depletion (lowering) of CD4 + and CD8 + lymphocytes and the presence of apoptotic cells in T cells of mesenteric lymph nodes and spleen of cats with FIP. It's a 2007 study! Based on other 1987 or 2004 studies by Dr Pedersen! ncbi.nlm.nih.gov/pmc/articles/P…
An increase in the spleen has been observed by CT in the analysis of the progression of Covid-19.

The spleen has functions in the immune system and coagulation functions and is indirectly affected by general systemic changes, such as microthrombi. ncbi.nlm.nih.gov/pmc/articles/P…
But it is that they have also been observed in autopsies ... vaccinated? ? those SAME spleen and mesenteric nodules damage!

Splenomegaly, hepatomegaly, and lymphocyte apoptosis! As in the PIF?

Can't you see the direct relationship between both diseases? ?

Thanks @janieyaya ?

And this thread from @BidoliNicola clearly explains how these SAME damages are produced by altering the NF-KB and TNF-α signaling pathway through the vaccine!

That is, the vaccine REPRODUCES the damage‼ ️

I lack lives to thank you Nicola for what you help in this pandemic ✨

Lymphocyte apoptosis occurs that leads to cell death, creating pretumor conditions, cancellation of innate immunity against other common viruses such as influenza, reactivation of latent bacterial pathogens ... ?

Rightly in the paper they say CAUTION.
In Pif, chronic overproduction of TNF-α also leads to cachexia (malnutrition and weakness).
In this study it was observed that the expression of TNF-α protein was higher in affected tissues and… it

showed a change in TNF-α from macrophages to lymphocytes‼ ️ pubmed.ncbi.nlm.nih.gov/14637034/
For those who want to read what causes TNF-α to be enhanced (Tumor Necrosis Factor alpha). Related to white blood cells, endothelium, infections and inflammations.
You can read more on wikipedia.

TNF-α is enhanced and Interferon 1 that protects us is decreased?.
Damage is being caused as if we had a THOUSAND PIFS IN HUMANS !! ? This is already insane.

We need SERIOUS solutions focused on the problem. I am about to ask for ANTIDOTE against these injections because there is more and more evidence of damage.
INCOMPETENCE or EVIL? ?
The response of type I Interferon, which helps to protect us from diseases, is diminished after vaccination? As you can read, it is suggested that within a month (ONE MONTH) the immune system of a vaccinated person is in a “NO privileged state Against another infection.
NON-PRIVILEGED STATE? ?
That is, since they do not protect against THIS virus, they will continue to click and obtain the same (or worse?) results, regardless of the “failures” as they are shielded? ?

And will they create a “YES PRIVILEGED STATUS” (lifetime) of YOUR income per dose sold? ?
Please take another look at the damage:
electrolyte changes, blood clotting, kidney function
changes, cholesterol and glucose metabolism changes.

"As if these (vaccinated) people had experienced an infection with SARS-CoV-2"

I'm not saying it, the scientists are saying it?
How can they
NOT reflect these damages in pharmacovigilance in SPAIN as secondary effects when people with vascular problems, anemia, tachycardias, arrhythmias, menstrual alterations, hyperhidrosis, hypoesthesia ... appear?

What are they blind to? To the true? ?
How long will we continue to ignore that THESE vaccines are not appropriate?

Neither third dose, nor fourth, nor anything at all. Damages difficult to treat are being created in the medium-long term if this injection dynamic is continued, influencing the SAME Spike protein ?
What do the incompetent do in a product that they have manufactured badly or with errors?
Obtain correction master, call for review, patch, update or withdraw product.

What do you do with THESE vaccines?

Inject more population so that effects and responsibilities are diluted? ?.
Each symptom that I read or ignored ailment, concern not addressed or neglected takes me further away from that part of the health system that THIS virus is uncovering as corrupt. Hopefully there are healthy and good people to redirect this

@threadreaderapp compile
Unroll please ?

✨ ♥ ️
 

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